Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YLR100W | 8.22 | 1.00E-16 | 1.41 | ERG27 | 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs |
YGR264C | 6.82 | 4.67E-12 | 1.21 | MES1 | Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs |
YMR236W | 5.60 | 1.06E-8 | 0.07 | TAF9 | Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3 |
YMR049C | 5.53 | 1.56E-8 | 1.35 | ERB1 | Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 |
YDR160W | 4.18 | 1.46E-5 | 0.15 | SSY1 | Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes |
YHR062C | 4.03 | 2.76E-5 | 0.33 | RPP1 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
YCL052C | 3.71 | 1.05E-4 | 0.09 | PBN1 | Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X |
YOR102W_d | 3.62 | 1.50E-4 | 0.22 | YOR102W_d | Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex |
YGR190C_d | 3.39 | 3.44E-4 | 0.03 | YGR190C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W |
YDR396W_d | 3.36 | 3.85E-4 | 0.45 | YDR396W_d | Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex |
YPR142C_d | 2.91 | 0.00179 | 0.01 | YPR142C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing |
YOR260W | 2.90 | 0.00186 | 0.10 | GCD1 | Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression |
YNR053C | 2.80 | 0.00255 | 0.26 | NOG2 | Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation |
YLL036C | 2.54 | 0.00557 | 0.02 | PRP19 | Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain |
YGL142C | 2.52 | 0.00589 | 1.80E-4 | GPI10 | Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog |