3-hydroxy-2-naphthoic acid

3-hydroxynaphthalene-2-carboxylic acid

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1823
Screen concentration 106.0 μM
Source TimTec (Natural product derivative library)
PubChem CID 7104
SMILES C1=CC=C2C=C(C(=CC2=C1)C(=O)O)O
Standardized SMILES OC(=O)c1cc2ccccc2cc1O
Molecular weight 188.1794
ALogP 2.13
H-bond donor count 2
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.62
% growth inhibition (Hom. pool) 3.32


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 7104
Download HIP data (tab-delimited text)  (excel)
Gene:BRL1(YHR036W)|FD-Score:3.78|P-value:7.74E-5|Clearance:0.41||SGD DESC:Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export Gene:ERG27(YLR100W)|FD-Score:4.29|P-value:8.94E-6|Clearance:0.51||SGD DESC:3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs Gene:ILS1(YBL076C)|FD-Score:4.4|P-value:5.35E-6|Clearance:0.51||SGD DESC:Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A Gene:IPI3(YNL182C)|FD-Score:-3.18|P-value:7.24E-4|Clearance:0||SGD DESC:Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene Gene:RRP46(YGR095C)|FD-Score:3.17|P-value:7.51E-4|Clearance:0.12||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5) Gene:RTT105(YER104W)|FD-Score:3.37|P-value:3.70E-4|Clearance:0.2||SGD DESC:Protein with a role in regulation of Ty1 transposition Gene:SEN54(YPL083C)|FD-Score:4.59|P-value:2.17E-6|Clearance:0.51||SGD DESC:Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p Gene:BRL1(YHR036W)|FD-Score:3.78|P-value:7.74E-5|Clearance:0.41||SGD DESC:Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export Gene:ERG27(YLR100W)|FD-Score:4.29|P-value:8.94E-6|Clearance:0.51||SGD DESC:3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs Gene:ILS1(YBL076C)|FD-Score:4.4|P-value:5.35E-6|Clearance:0.51||SGD DESC:Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A Gene:IPI3(YNL182C)|FD-Score:-3.18|P-value:7.24E-4|Clearance:0||SGD DESC:Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene Gene:RRP46(YGR095C)|FD-Score:3.17|P-value:7.51E-4|Clearance:0.12||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5) Gene:RTT105(YER104W)|FD-Score:3.37|P-value:3.70E-4|Clearance:0.2||SGD DESC:Protein with a role in regulation of Ty1 transposition Gene:SEN54(YPL083C)|FD-Score:4.59|P-value:2.17E-6|Clearance:0.51||SGD DESC:Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 7104
Download HOP data (tab-delimited text)  (excel)
Gene:ALG8(YOR067C)|FD-Score:-3.39|P-value:3.54E-4||SGD DESC:Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p Gene:ARO1(YDR127W)|FD-Score:3.1|P-value:9.61E-4||SGD DESC:Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Gene:ATG14(YBR128C)|FD-Score:3.8|P-value:7.19E-5||SGD DESC:Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor Gene:ATG27(YJL178C)|FD-Score:-3.39|P-value:3.46E-4||SGD DESC:Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site Gene:ATG3(YNR007C)|FD-Score:-3.17|P-value:7.51E-4||SGD DESC:E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p Gene:BSP1(YPR171W)|FD-Score:3.24|P-value:5.90E-4||SGD DESC:Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton Gene:BUD16(YEL029C)|FD-Score:-3.15|P-value:8.26E-4||SGD DESC:Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) Gene:CDH1(YGL003C)|FD-Score:3.12|P-value:9.17E-4||SGD DESC:Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p Gene:COG6(YNL041C)|FD-Score:3.89|P-value:5.00E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG7(YGL005C)|FD-Score:3.29|P-value:4.98E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:FET4(YMR319C)|FD-Score:-3.45|P-value:2.82E-4||SGD DESC:Low-affinity Fe(II) transporter of the plasma membrane Gene:FMT1(YBL013W)|FD-Score:3.15|P-value:8.09E-4||SGD DESC:Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate Gene:FPR1(YNL135C)|FD-Score:3.28|P-value:5.10E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function Gene:GCV1(YDR019C)|FD-Score:3.2|P-value:6.93E-4||SGD DESC:T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm Gene:HAL1(YPR005C)|FD-Score:3.92|P-value:4.48E-5||SGD DESC:Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p Gene:HOM3(YER052C)|FD-Score:-3.73|P-value:9.45E-5||SGD DESC:Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis Gene:HPA3(YEL066W)|FD-Score:3.34|P-value:4.14E-4||SGD DESC:D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro Gene:HSL7(YBR133C)|FD-Score:4.04|P-value:2.62E-5||SGD DESC:Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress Gene:LRO1(YNR008W)|FD-Score:3.81|P-value:7.00E-5||SGD DESC:Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase Gene:LSB6(YJL100W)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization Gene:MDV1(YJL112W)|FD-Score:-3.33|P-value:4.33E-4||SGD DESC:Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication Gene:MGA1(YGR249W)|FD-Score:3.45|P-value:2.85E-4||SGD DESC:Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants Gene:MRP4(YHL004W)|FD-Score:4.27|P-value:9.92E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MRPL32(YCR003W)|FD-Score:3.19|P-value:7.15E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress Gene:MRPS5(YBR251W)|FD-Score:3.56|P-value:1.85E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:NDE1(YMR145C)|FD-Score:-3.61|P-value:1.55E-4||SGD DESC:Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain Gene:PHO91(YNR013C)|FD-Score:-3.24|P-value:5.97E-4||SGD DESC:Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth Gene:PML39(YML107C)|FD-Score:3.55|P-value:1.96E-4||SGD DESC:Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes Gene:PRM10(YJL108C)|FD-Score:-3.88|P-value:5.22E-5||SGD DESC:Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:RHO5(YNL180C)|FD-Score:-3.86|P-value:5.62E-5||SGD DESC:Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity Gene:RMD9(YGL107C)|FD-Score:3.76|P-value:8.49E-5||SGD DESC:Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes Gene:RTS3(YGR161C_p)|FD-Score:4.73|P-value:1.10E-6||SGD DESC:Putative component of the protein phosphatase type 2A complex Gene:SWC5(YBR231C)|FD-Score:-3.19|P-value:7.14E-4||SGD DESC:Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress Gene:SWF1(YDR126W)|FD-Score:4.83|P-value:6.87E-7||SGD DESC:Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion Gene:TRM3(YDL112W)|FD-Score:-3.59|P-value:1.63E-4||SGD DESC:2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs Gene:TRP1(YDR007W)|FD-Score:4.35|P-value:6.91E-6||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP3(YKL211C)|FD-Score:6.74|P-value:7.84E-12||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TRP4(YDR354W)|FD-Score:5.73|P-value:4.94E-9||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:TRP5(YGL026C)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis Gene:UIP3(YAR027W)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family Gene:YBL028C(YBL028C)|FD-Score:3.86|P-value:5.73E-5||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Gene:YBR221W-A(YBR221W-A_p)|FD-Score:3.82|P-value:6.63E-5||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YBT1(YLL048C)|FD-Score:4.18|P-value:1.49E-5||SGD DESC:Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters Gene:YCR025C(YCR025C_d)|FD-Score:3.75|P-value:8.71E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene Gene:YDR008C(YDR008C_d)|FD-Score:4.39|P-value:5.64E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR249C(YDR249C_p)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Putative protein of unknown function Gene:YDR379C-A(YDR379C-A)|FD-Score:3.54|P-value:2.01E-4||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy Gene:YER087C-A(YER087C-A_d)|FD-Score:3.8|P-value:7.15E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase Gene:YGR021W(YGR021W_p)|FD-Score:-4.36|P-value:6.47E-6||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YIL168W(YIL168W)|FD-Score:3.97|P-value:3.59E-5||SGD DESC:Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase Gene:YJL070C(YJL070C_p)|FD-Score:4.05|P-value:2.57E-5||SGD DESC:Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication Gene:YMR052C-A(YMR052C-A_d)|FD-Score:4.28|P-value:9.29E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR155W(YMR155W_p)|FD-Score:4.18|P-value:1.44E-5||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Gene:YMR245W(YMR245W_d)|FD-Score:3.57|P-value:1.76E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR186W(YOR186W_p)|FD-Score:5.49|P-value:1.96E-8||SGD DESC:Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication Gene:YOR385W(YOR385W_p)|FD-Score:3.28|P-value:5.18E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene Gene:ALG8(YOR067C)|FD-Score:-3.39|P-value:3.54E-4||SGD DESC:Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p Gene:ARO1(YDR127W)|FD-Score:3.1|P-value:9.61E-4||SGD DESC:Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Gene:ATG14(YBR128C)|FD-Score:3.8|P-value:7.19E-5||SGD DESC:Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor Gene:ATG27(YJL178C)|FD-Score:-3.39|P-value:3.46E-4||SGD DESC:Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site Gene:ATG3(YNR007C)|FD-Score:-3.17|P-value:7.51E-4||SGD DESC:E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p Gene:BSP1(YPR171W)|FD-Score:3.24|P-value:5.90E-4||SGD DESC:Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton Gene:BUD16(YEL029C)|FD-Score:-3.15|P-value:8.26E-4||SGD DESC:Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) Gene:CDH1(YGL003C)|FD-Score:3.12|P-value:9.17E-4||SGD DESC:Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p Gene:COG6(YNL041C)|FD-Score:3.89|P-value:5.00E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG7(YGL005C)|FD-Score:3.29|P-value:4.98E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:FET4(YMR319C)|FD-Score:-3.45|P-value:2.82E-4||SGD DESC:Low-affinity Fe(II) transporter of the plasma membrane Gene:FMT1(YBL013W)|FD-Score:3.15|P-value:8.09E-4||SGD DESC:Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate Gene:FPR1(YNL135C)|FD-Score:3.28|P-value:5.10E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function Gene:GCV1(YDR019C)|FD-Score:3.2|P-value:6.93E-4||SGD DESC:T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm Gene:HAL1(YPR005C)|FD-Score:3.92|P-value:4.48E-5||SGD DESC:Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p Gene:HOM3(YER052C)|FD-Score:-3.73|P-value:9.45E-5||SGD DESC:Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis Gene:HPA3(YEL066W)|FD-Score:3.34|P-value:4.14E-4||SGD DESC:D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro Gene:HSL7(YBR133C)|FD-Score:4.04|P-value:2.62E-5||SGD DESC:Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress Gene:LRO1(YNR008W)|FD-Score:3.81|P-value:7.00E-5||SGD DESC:Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase Gene:LSB6(YJL100W)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization Gene:MDV1(YJL112W)|FD-Score:-3.33|P-value:4.33E-4||SGD DESC:Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication Gene:MGA1(YGR249W)|FD-Score:3.45|P-value:2.85E-4||SGD DESC:Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants Gene:MRP4(YHL004W)|FD-Score:4.27|P-value:9.92E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MRPL32(YCR003W)|FD-Score:3.19|P-value:7.15E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress Gene:MRPS5(YBR251W)|FD-Score:3.56|P-value:1.85E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:NDE1(YMR145C)|FD-Score:-3.61|P-value:1.55E-4||SGD DESC:Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain Gene:PHO91(YNR013C)|FD-Score:-3.24|P-value:5.97E-4||SGD DESC:Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth Gene:PML39(YML107C)|FD-Score:3.55|P-value:1.96E-4||SGD DESC:Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes Gene:PRM10(YJL108C)|FD-Score:-3.88|P-value:5.22E-5||SGD DESC:Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:RHO5(YNL180C)|FD-Score:-3.86|P-value:5.62E-5||SGD DESC:Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity Gene:RMD9(YGL107C)|FD-Score:3.76|P-value:8.49E-5||SGD DESC:Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes Gene:RTS3(YGR161C_p)|FD-Score:4.73|P-value:1.10E-6||SGD DESC:Putative component of the protein phosphatase type 2A complex Gene:SWC5(YBR231C)|FD-Score:-3.19|P-value:7.14E-4||SGD DESC:Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress Gene:SWF1(YDR126W)|FD-Score:4.83|P-value:6.87E-7||SGD DESC:Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion Gene:TRM3(YDL112W)|FD-Score:-3.59|P-value:1.63E-4||SGD DESC:2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs Gene:TRP1(YDR007W)|FD-Score:4.35|P-value:6.91E-6||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP3(YKL211C)|FD-Score:6.74|P-value:7.84E-12||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TRP4(YDR354W)|FD-Score:5.73|P-value:4.94E-9||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:TRP5(YGL026C)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis Gene:UIP3(YAR027W)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family Gene:YBL028C(YBL028C)|FD-Score:3.86|P-value:5.73E-5||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Gene:YBR221W-A(YBR221W-A_p)|FD-Score:3.82|P-value:6.63E-5||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YBT1(YLL048C)|FD-Score:4.18|P-value:1.49E-5||SGD DESC:Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters Gene:YCR025C(YCR025C_d)|FD-Score:3.75|P-value:8.71E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene Gene:YDR008C(YDR008C_d)|FD-Score:4.39|P-value:5.64E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR249C(YDR249C_p)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Putative protein of unknown function Gene:YDR379C-A(YDR379C-A)|FD-Score:3.54|P-value:2.01E-4||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy Gene:YER087C-A(YER087C-A_d)|FD-Score:3.8|P-value:7.15E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase Gene:YGR021W(YGR021W_p)|FD-Score:-4.36|P-value:6.47E-6||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YIL168W(YIL168W)|FD-Score:3.97|P-value:3.59E-5||SGD DESC:Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase Gene:YJL070C(YJL070C_p)|FD-Score:4.05|P-value:2.57E-5||SGD DESC:Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication Gene:YMR052C-A(YMR052C-A_d)|FD-Score:4.28|P-value:9.29E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR155W(YMR155W_p)|FD-Score:4.18|P-value:1.44E-5||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Gene:YMR245W(YMR245W_d)|FD-Score:3.57|P-value:1.76E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR186W(YOR186W_p)|FD-Score:5.49|P-value:1.96E-8||SGD DESC:Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication Gene:YOR385W(YOR385W_p)|FD-Score:3.28|P-value:5.18E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YPL083C4.592.17E-60.51SEN54Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
YBL076C4.405.35E-60.51ILS1Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A
YLR100W4.298.94E-60.51ERG273-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs
YHR036W3.787.74E-50.41BRL1Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
YER104W3.373.70E-40.20RTT105Protein with a role in regulation of Ty1 transposition
YGR095C3.177.51E-40.12RRP46Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
YER094C3.060.001110.03PUP3Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
YKR081C3.030.001240.04RPF2Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
YKL012W2.980.001420.19PRP40U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
YPL010W2.800.002570.03RET3Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YDR196C2.770.002820.03CAB5Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies
YNL232W2.740.003040.04CSL4Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
YDR353W2.700.003480.01TRR1Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication
YPR186C2.690.003600.04PZF1Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA
YGR119C2.650.004030.00NUP57FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YKL211C6.747.84E-12TRP3Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
YDR354W5.734.94E-9TRP4Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
YOR186W_p5.491.96E-8YOR186W_pPutative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication
YDR126W4.836.87E-7SWF1Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion
YGR161C_p4.731.10E-6RTS3_pPutative component of the protein phosphatase type 2A complex
YDR008C_d4.395.64E-6YDR008C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR007W4.356.91E-6TRP1Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
YMR052C-A_d4.289.29E-6YMR052C-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHL004W4.279.92E-6MRP4Mitochondrial ribosomal protein of the small subunit
YMR155W_p4.181.44E-5YMR155W_pPutative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen
YLL048C4.181.49E-5YBT1Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
YJL070C_p4.052.57E-5YJL070C_pPutative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication
YBR133C4.042.62E-5HSL7Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress
YIL168W3.973.59E-5YIL168WOpen reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase
YPR005C3.924.48E-5HAL1Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p

GO enrichment analysis for SGTC_1823
biological processes

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2561.10E-88SGTC_2758dehydroepiandrosterone 69.3 μMMiscellaneous58810.0701754
0.2494.99E-84SGTC_2650prasterone 100.0 μMMicrosource (Natural product library)167592470.0701754
0.2452.87E-81SGTC_2642cholecalciferol 100.0 μMMicrosource (Natural product library)98214650.027027
0.2441.73E-80SGTC_14823346-2049 8.5 μMChemDiv (Drug-like library)38268040.106061
0.2436.20E-80SGTC_1617st002906 78.0 μMTimTec (Natural product derivative library)51508590.125
0.2421.04E-79SGTC_22547938975 95.2 μMChembridge (Fragment library)29692770.0740741
0.2417.03E-79SGTC_2607solasodine 47.4 μMMicrosource (Natural product library)67106420.038961
0.2397.91E-78SGTC_18825615643 20.0 μMMiscellaneous22530750.0735294TRP & mitochondrial translation
0.2398.12E-78SGTC_24885268135 45.7 μMMiscellaneous12703560.122449
0.2391.18E-77SGTC_18835-benzylidenerhodanine 20.0 μMMiscellaneous12732100.133333TRP & mitochondrial translation
0.2392.54E-77SGTC_2618avocadyne 43.4 μMMicrosource (Natural product library)30151890.0212766
0.2355.16E-75SGTC_24865283202 22.4 μMMiscellaneous13777510.12766
0.2338.06E-74SGTC_24785763493 32.3 μMMiscellaneous13655760.0714286
0.2331.27E-73SGTC_2669eugenol 100.0 μMMicrosource (Natural product library)33140.159091
0.2312.13E-72SGTC_21976588183 93.1 μMChembridge (Fragment library)8841360.207547

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2235salicylic acid500 μM0.555556338Miscellaneous138.120741.21723
SGTC_8500388-014375.9 μM0.51351467273ChemDiv (Drug-like library)277.31723.76722
SGTC_1090132-003633.7 μM0.47567274ChemDiv (Drug-like library)293.31663.26423
SGTC_7851270-011165.3 μM0.441866741994ChemDiv (Drug-like library)307.300122.53735
SGTC_8981000-084928.3 μM0.4318186751807ChemDiv (Drug-like library)356.374042.72334
SGTC_1642st00958277.7 μM0.4256739311TimTec (Natural product derivative library)257.241441.48735RPP1 & pyrimidine depletion
SGTC_6671498-104459 μM0.3953496739982ChemDiv (Drug-like library)291.300722.77924RPP1 & pyrimidine depletion
SGTC_1836st05564281 μM0.3870978571TimTec (Natural product derivative library)246.21552.26645
SGTC_5850kpi-0023191 μM0.37564601ChemDiv (Drug-like library)272.33893.62723
SGTC_23559061122103.12 μM0.3589745302957Chembridge (Fragment library)215.247822.07312