st052143

3-[[4-[(4-methylphenyl)methyl]piperazin-1-yl]methyl]-1H-indole

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1825
Screen concentration 62.6 μM
Source TimTec (Natural product derivative library)
PubChem CID 674173
SMILES CC1=CC=C(C=C1)CN2CCN(CC2)CC3=CNC4=CC=CC=C43
Standardized SMILES Cc1ccc(CN2CCN(Cc3c[nH]c4ccccc34)CC2)cc1
Molecular weight 319.4433
ALogP 4.22
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.27
% growth inhibition (Hom. pool) 5.18


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 674173
Download HIP data (tab-delimited text)  (excel)
Gene:CCT5(YJR064W)|FD-Score:3.83|P-value:6.37E-5|Clearance:0.02||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CFD1(YIL003W)|FD-Score:3.35|P-value:3.97E-4|Clearance:0.04||SGD DESC:Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol Gene:ECM9(YKR004C)|FD-Score:-3.2|P-value:6.92E-4|Clearance:0||SGD DESC:Non-essential protein of unknown function Gene:FCP1(YMR277W)|FD-Score:-3.44|P-value:2.94E-4|Clearance:0||SGD DESC:Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) Gene:LSG1(YGL099W)|FD-Score:3.86|P-value:5.62E-5|Clearance:0.01||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MNP1(YGL068W)|FD-Score:-3.75|P-value:8.86E-5|Clearance:0||SGD DESC:Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth Gene:NAF1(YNL124W)|FD-Score:3.32|P-value:4.53E-4|Clearance:0.13||SGD DESC:RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p Gene:OLE1(YGL055W)|FD-Score:4.94|P-value:3.81E-7|Clearance:0.71||SGD DESC:Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria Gene:PUP1(YOR157C)|FD-Score:4.9|P-value:4.68E-7|Clearance:0.71||SGD DESC:Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z Gene:QNS1(YHR074W)|FD-Score:3.76|P-value:8.64E-5|Clearance:0.33||SGD DESC:Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide Gene:RRP4(YHR069C)|FD-Score:3.85|P-value:5.82E-5|Clearance:0.02||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) Gene:RTT105(YER104W)|FD-Score:3.43|P-value:3.07E-4|Clearance:0.07||SGD DESC:Protein with a role in regulation of Ty1 transposition Gene:SRP1(YNL189W)|FD-Score:3.19|P-value:7.20E-4|Clearance:0.04||SGD DESC:Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation Gene:TRM112(YNR046W)|FD-Score:4.2|P-value:1.36E-5|Clearance:0.33||SGD DESC:Protein involved in methylation of tRNA, rRNA, and translation factors; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; relative distribution to the nucleus increases upon DNA replication stress Gene:TRS120(YDR407C)|FD-Score:3.81|P-value:6.83E-5|Clearance:0.06||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic Gene:ULP1(YPL020C)|FD-Score:-3.96|P-value:3.80E-5|Clearance:0||SGD DESC:Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions Gene:YDL196W(YDL196W_d)|FD-Score:3.15|P-value:8.15E-4|Clearance:0.16||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:CCT5(YJR064W)|FD-Score:3.83|P-value:6.37E-5|Clearance:0.02||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CFD1(YIL003W)|FD-Score:3.35|P-value:3.97E-4|Clearance:0.04||SGD DESC:Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol Gene:ECM9(YKR004C)|FD-Score:-3.2|P-value:6.92E-4|Clearance:0||SGD DESC:Non-essential protein of unknown function Gene:FCP1(YMR277W)|FD-Score:-3.44|P-value:2.94E-4|Clearance:0||SGD DESC:Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) Gene:LSG1(YGL099W)|FD-Score:3.86|P-value:5.62E-5|Clearance:0.01||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MNP1(YGL068W)|FD-Score:-3.75|P-value:8.86E-5|Clearance:0||SGD DESC:Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth Gene:NAF1(YNL124W)|FD-Score:3.32|P-value:4.53E-4|Clearance:0.13||SGD DESC:RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p Gene:OLE1(YGL055W)|FD-Score:4.94|P-value:3.81E-7|Clearance:0.71||SGD DESC:Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria Gene:PUP1(YOR157C)|FD-Score:4.9|P-value:4.68E-7|Clearance:0.71||SGD DESC:Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z Gene:QNS1(YHR074W)|FD-Score:3.76|P-value:8.64E-5|Clearance:0.33||SGD DESC:Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide Gene:RRP4(YHR069C)|FD-Score:3.85|P-value:5.82E-5|Clearance:0.02||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) Gene:RTT105(YER104W)|FD-Score:3.43|P-value:3.07E-4|Clearance:0.07||SGD DESC:Protein with a role in regulation of Ty1 transposition Gene:SRP1(YNL189W)|FD-Score:3.19|P-value:7.20E-4|Clearance:0.04||SGD DESC:Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation Gene:TRM112(YNR046W)|FD-Score:4.2|P-value:1.36E-5|Clearance:0.33||SGD DESC:Protein involved in methylation of tRNA, rRNA, and translation factors; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; relative distribution to the nucleus increases upon DNA replication stress Gene:TRS120(YDR407C)|FD-Score:3.81|P-value:6.83E-5|Clearance:0.06||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic Gene:ULP1(YPL020C)|FD-Score:-3.96|P-value:3.80E-5|Clearance:0||SGD DESC:Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions Gene:YDL196W(YDL196W_d)|FD-Score:3.15|P-value:8.15E-4|Clearance:0.16||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 674173
Download HOP data (tab-delimited text)  (excel)
Gene:ADD66(YKL206C)|FD-Score:3.38|P-value:3.59E-4||SGD DESC:Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly Gene:ATP25(YMR098C)|FD-Score:3.75|P-value:8.87E-5||SGD DESC:Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene Gene:AVT4(YNL101W)|FD-Score:3.81|P-value:6.84E-5||SGD DESC:Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BRO1(YPL084W)|FD-Score:4.33|P-value:7.53E-6||SGD DESC:Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes Gene:CAR1(YPL111W)|FD-Score:-4.16|P-value:1.60E-5||SGD DESC:Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance Gene:CRS5(YOR031W)|FD-Score:3.18|P-value:7.32E-4||SGD DESC:Copper-binding metallothionein, required for wild-type copper resistance Gene:CSG2(YBR036C)|FD-Score:-3.24|P-value:5.91E-4||SGD DESC:Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress Gene:EST1(YLR233C)|FD-Score:-3.21|P-value:6.62E-4||SGD DESC:TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA Gene:FAR11(YNL127W)|FD-Score:3.66|P-value:1.26E-4||SGD DESC:Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 Gene:FAR7(YFR008W)|FD-Score:3.4|P-value:3.43E-4||SGD DESC:Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress Gene:FRT2(YAL028W)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication Gene:FSH3(YOR280C)|FD-Score:4.07|P-value:2.35E-5||SGD DESC:Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2 Gene:GLR1(YPL091W)|FD-Score:4.22|P-value:1.24E-5||SGD DESC:Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress Gene:GRX2(YDR513W)|FD-Score:4.29|P-value:8.76E-6||SGD DESC:Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication Gene:HST2(YPL015C)|FD-Score:3.27|P-value:5.36E-4||SGD DESC:Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export Gene:HTL1(YCR020W-B)|FD-Score:3.26|P-value:5.65E-4||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:IBA57(YJR122W)|FD-Score:3.87|P-value:5.40E-5||SGD DESC:Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system Gene:KEL2(YGR238C)|FD-Score:3.83|P-value:6.36E-5||SGD DESC:Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate Gene:MCT1(YOR221C)|FD-Score:3.32|P-value:4.57E-4||SGD DESC:Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling Gene:MDM38(YOL027C)|FD-Score:3.33|P-value:4.32E-4||SGD DESC:Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome Gene:MSG5(YNL053W)|FD-Score:-3.24|P-value:6.00E-4||SGD DESC:Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p Gene:MSS18(YPR134W)|FD-Score:3.19|P-value:7.00E-4||SGD DESC:Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions Gene:NOP16(YER002W)|FD-Score:4.2|P-value:1.31E-5||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis Gene:NTH2(YBR001C)|FD-Score:5.52|P-value:1.73E-8||SGD DESC:Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication Gene:PES4(YFR023W)|FD-Score:-3.61|P-value:1.54E-4||SGD DESC:Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication Gene:PEX18(YHR160C)|FD-Score:6.24|P-value:2.14E-10||SGD DESC:Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p Gene:PFK1(YGR240C)|FD-Score:5|P-value:2.86E-7||SGD DESC:Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes Gene:PGD1(YGL025C)|FD-Score:-3.15|P-value:8.25E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor Gene:PSH1(YOL054W)|FD-Score:3.85|P-value:5.96E-5||SGD DESC:E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p Gene:PUF6(YDR496C)|FD-Score:3.25|P-value:5.81E-4||SGD DESC:Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis Gene:PUG1(YER185W)|FD-Score:6.24|P-value:2.13E-10||SGD DESC:Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins Gene:RCR1(YBR005W)|FD-Score:-3.19|P-value:7.16E-4||SGD DESC:Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication Gene:RFM1(YOR279C)|FD-Score:7.1|P-value:6.20E-13||SGD DESC:DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance Gene:RMD1(YDL001W)|FD-Score:3.17|P-value:7.63E-4||SGD DESC:Cytoplasmic protein required for sporulation Gene:RPN4(YDL020C)|FD-Score:3.14|P-value:8.50E-4||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:SCT1(YBL011W)|FD-Score:3.44|P-value:2.89E-4||SGD DESC:Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed Gene:SFA1(YDL168W)|FD-Score:-3.72|P-value:9.82E-5||SGD DESC:Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress Gene:TPN1(YGL186C)|FD-Score:4.35|P-value:6.88E-6||SGD DESC:Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p Gene:TPO1(YLL028W)|FD-Score:3.22|P-value:6.41E-4||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane Gene:TPO4(YOR273C)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane Gene:VMA13(YPR036W)|FD-Score:-3.12|P-value:9.15E-4||SGD DESC:Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase Gene:VPS1(YKR001C)|FD-Score:-3.11|P-value:9.35E-4||SGD DESC:Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis Gene:VPS70(YJR126C)|FD-Score:3.52|P-value:2.15E-4||SGD DESC:Protein of unknown function involved in vacuolar protein sorting Gene:YBR053C(YBR053C_p)|FD-Score:3.96|P-value:3.82E-5||SGD DESC:Putative protein of unknown function; induced by cell wall perturbation Gene:YFL041W-A(YFL041W-A_p)|FD-Score:5.45|P-value:2.57E-8||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YIL046W-A(YIL046W-A_p)|FD-Score:-3.28|P-value:5.15E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YJL144W(YJL144W)|FD-Score:3.73|P-value:9.66E-5||SGD DESC:Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress Gene:YLR342W-A(YLR342W-A_p)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:Putative protein of unknown function Gene:YML079W(YML079W_p)|FD-Score:-3.44|P-value:2.95E-4||SGD DESC:Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm Gene:YMR155W(YMR155W_p)|FD-Score:3.41|P-value:3.23E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Gene:YNL122C(YNL122C_p)|FD-Score:3.35|P-value:3.99E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene Gene:YPR077C(YPR077C_d)|FD-Score:3.33|P-value:4.38E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1 Gene:ADD66(YKL206C)|FD-Score:3.38|P-value:3.59E-4||SGD DESC:Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly Gene:ATP25(YMR098C)|FD-Score:3.75|P-value:8.87E-5||SGD DESC:Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene Gene:AVT4(YNL101W)|FD-Score:3.81|P-value:6.84E-5||SGD DESC:Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BRO1(YPL084W)|FD-Score:4.33|P-value:7.53E-6||SGD DESC:Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes Gene:CAR1(YPL111W)|FD-Score:-4.16|P-value:1.60E-5||SGD DESC:Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance Gene:CRS5(YOR031W)|FD-Score:3.18|P-value:7.32E-4||SGD DESC:Copper-binding metallothionein, required for wild-type copper resistance Gene:CSG2(YBR036C)|FD-Score:-3.24|P-value:5.91E-4||SGD DESC:Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress Gene:EST1(YLR233C)|FD-Score:-3.21|P-value:6.62E-4||SGD DESC:TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA Gene:FAR11(YNL127W)|FD-Score:3.66|P-value:1.26E-4||SGD DESC:Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 Gene:FAR7(YFR008W)|FD-Score:3.4|P-value:3.43E-4||SGD DESC:Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress Gene:FRT2(YAL028W)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication Gene:FSH3(YOR280C)|FD-Score:4.07|P-value:2.35E-5||SGD DESC:Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2 Gene:GLR1(YPL091W)|FD-Score:4.22|P-value:1.24E-5||SGD DESC:Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress Gene:GRX2(YDR513W)|FD-Score:4.29|P-value:8.76E-6||SGD DESC:Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication Gene:HST2(YPL015C)|FD-Score:3.27|P-value:5.36E-4||SGD DESC:Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export Gene:HTL1(YCR020W-B)|FD-Score:3.26|P-value:5.65E-4||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:IBA57(YJR122W)|FD-Score:3.87|P-value:5.40E-5||SGD DESC:Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system Gene:KEL2(YGR238C)|FD-Score:3.83|P-value:6.36E-5||SGD DESC:Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate Gene:MCT1(YOR221C)|FD-Score:3.32|P-value:4.57E-4||SGD DESC:Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling Gene:MDM38(YOL027C)|FD-Score:3.33|P-value:4.32E-4||SGD DESC:Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome Gene:MSG5(YNL053W)|FD-Score:-3.24|P-value:6.00E-4||SGD DESC:Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p Gene:MSS18(YPR134W)|FD-Score:3.19|P-value:7.00E-4||SGD DESC:Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions Gene:NOP16(YER002W)|FD-Score:4.2|P-value:1.31E-5||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis Gene:NTH2(YBR001C)|FD-Score:5.52|P-value:1.73E-8||SGD DESC:Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication Gene:PES4(YFR023W)|FD-Score:-3.61|P-value:1.54E-4||SGD DESC:Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication Gene:PEX18(YHR160C)|FD-Score:6.24|P-value:2.14E-10||SGD DESC:Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p Gene:PFK1(YGR240C)|FD-Score:5|P-value:2.86E-7||SGD DESC:Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes Gene:PGD1(YGL025C)|FD-Score:-3.15|P-value:8.25E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor Gene:PSH1(YOL054W)|FD-Score:3.85|P-value:5.96E-5||SGD DESC:E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p Gene:PUF6(YDR496C)|FD-Score:3.25|P-value:5.81E-4||SGD DESC:Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis Gene:PUG1(YER185W)|FD-Score:6.24|P-value:2.13E-10||SGD DESC:Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins Gene:RCR1(YBR005W)|FD-Score:-3.19|P-value:7.16E-4||SGD DESC:Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication Gene:RFM1(YOR279C)|FD-Score:7.1|P-value:6.20E-13||SGD DESC:DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance Gene:RMD1(YDL001W)|FD-Score:3.17|P-value:7.63E-4||SGD DESC:Cytoplasmic protein required for sporulation Gene:RPN4(YDL020C)|FD-Score:3.14|P-value:8.50E-4||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:SCT1(YBL011W)|FD-Score:3.44|P-value:2.89E-4||SGD DESC:Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed Gene:SFA1(YDL168W)|FD-Score:-3.72|P-value:9.82E-5||SGD DESC:Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress Gene:TPN1(YGL186C)|FD-Score:4.35|P-value:6.88E-6||SGD DESC:Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p Gene:TPO1(YLL028W)|FD-Score:3.22|P-value:6.41E-4||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane Gene:TPO4(YOR273C)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane Gene:VMA13(YPR036W)|FD-Score:-3.12|P-value:9.15E-4||SGD DESC:Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase Gene:VPS1(YKR001C)|FD-Score:-3.11|P-value:9.35E-4||SGD DESC:Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis Gene:VPS70(YJR126C)|FD-Score:3.52|P-value:2.15E-4||SGD DESC:Protein of unknown function involved in vacuolar protein sorting Gene:YBR053C(YBR053C_p)|FD-Score:3.96|P-value:3.82E-5||SGD DESC:Putative protein of unknown function; induced by cell wall perturbation Gene:YFL041W-A(YFL041W-A_p)|FD-Score:5.45|P-value:2.57E-8||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YIL046W-A(YIL046W-A_p)|FD-Score:-3.28|P-value:5.15E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YJL144W(YJL144W)|FD-Score:3.73|P-value:9.66E-5||SGD DESC:Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress Gene:YLR342W-A(YLR342W-A_p)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:Putative protein of unknown function Gene:YML079W(YML079W_p)|FD-Score:-3.44|P-value:2.95E-4||SGD DESC:Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm Gene:YMR155W(YMR155W_p)|FD-Score:3.41|P-value:3.23E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Gene:YNL122C(YNL122C_p)|FD-Score:3.35|P-value:3.99E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene Gene:YPR077C(YPR077C_d)|FD-Score:3.33|P-value:4.38E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL055W4.943.81E-70.71OLE1Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YOR157C4.904.68E-70.71PUP1Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
YNR046W4.201.36E-50.33TRM112Protein involved in methylation of tRNA, rRNA, and translation factors; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; relative distribution to the nucleus increases upon DNA replication stress
YGL099W3.865.62E-50.01LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YHR069C3.855.82E-50.02RRP4Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
YJR064W3.836.37E-50.02CCT5Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YDR407C3.816.83E-50.06TRS120One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YHR074W3.768.64E-50.33QNS1Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
YER104W3.433.07E-40.07RTT105Protein with a role in regulation of Ty1 transposition
YIL003W3.353.97E-40.04CFD1Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
YNL124W3.324.53E-40.13NAF1RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
YNL189W3.197.20E-40.04SRP1Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
YDL196W_d3.158.15E-40.16YDL196W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YFR051C2.990.001380.21RET2Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YPL131W2.780.002700.01RPL5Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR279C7.106.20E-13RFM1DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
YER185W6.242.13E-10PUG1Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins
YHR160C6.242.14E-10PEX18Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p
YBR001C5.521.73E-8NTH2Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication
YFL041W-A_p5.452.57E-8YFL041W-A_pPutative protein of unknown function; identified by fungal homology and RT-PCR
YGR240C5.002.86E-7PFK1Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YGL186C4.356.88E-6TPN1Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p
YPL084W4.337.53E-6BRO1Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
YDR513W4.298.76E-6GRX2Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication
YPL091W4.221.24E-5GLR1Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress
YER002W4.201.31E-5NOP16Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YOR280C4.072.35E-5FSH3Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2
YBR053C_p3.963.82E-5YBR053C_pPutative protein of unknown function; induced by cell wall perturbation
YJR122W3.875.40E-5IBA57Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system
YOL054W3.855.96E-5PSH1E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p

GO enrichment analysis for SGTC_1825
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1071.77E-16SGTC_1070indatraline 8.8 μMNIH Clinical Collection103144720.11290360S ribosome export
0.1024.69E-15SGTC_1165k072-0275 30.3 μMChemDiv (Drug-like library)61535230.112903
0.0977.66E-14SGTC_29389059746 27.3 μMChembridge (Drug-like library)64717690.138889fatty acid desaturase (OLE1)
0.0831.47E-10SGTC_23859074692 200.0 μMChembridge (Fragment library)170469060.0943396
0.0807.11E-10SGTC_7651319-0117 244.0 μMChemDiv (Drug-like library)34877460.10588260S ribosome export
0.0782.02E-9SGTC_1103duloxetine 36.1 μMNIH Clinical Collection608350.134328
0.0782.08E-9SGTC_26602',4'-dihydroxychalcone 17.1 μMTimTec (Pure natural product library)53572180.0833333
0.0782.21E-9SGTC_1999st074831 12.5 μMTimTec (Natural product derivative library)171125230.311475plasma membrane duress
0.0772.56E-9SGTC_30399090270 49.5 μMChembridge (Drug-like library)171737500.106061RPP1 & pyrimidine depletion
0.0741.48E-8SGTC_970535-0701 19.1 μMChemDiv (Drug-like library)28320130.18181860S ribosome export
0.0722.87E-8SGTC_30969117468 49.5 μMChembridge (Drug-like library)413163110.140625
0.0714.06E-8SGTC_32809140961 49.5 μMChembridge (Drug-like library)49012260.14084560S ribosome export
0.0708.56E-8SGTC_20505263056 171.0 μMChembridge (Fragment library)7634680.354167fatty acid desaturase (OLE1)
0.0681.69E-7SGTC_623k072-0108 16.9 μMChemDiv (Drug-like library)53828030.0757576heme biosynthesis & mitochondrial translocase
0.0672.20E-7SGTC_1664st014217 9.0 μMTimTec (Natural product derivative library)39827820.060975660S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_20515263410176 μM0.7227584Chembridge (Fragment library)229.320762.15412
SGTC_1818st05213656.3 μM0.630435674169TimTec (Natural product derivative library)339.861784.40212NEO1-PIK1
SGTC_1754st04206516.14 μM0.6279071126236TimTec (Natural product derivative library)355.47544.64612NEO1-PIK1
SGTC_9453381-076811.3 μM0.6279071126236ChemDiv (Drug-like library)355.47544.64612endomembrane recycling
SGTC_14554262-0120131 μM0.51529587ChemDiv (Drug-like library)308.460424.87302plasma membrane duress
SGTC_452diindolylmethane8 μM0.4615383071ICCB bioactive library246.306464.39120RNA processing & uracil transport
SGTC_2588indole-3-carbinol100 μM0.4390243712Microsource (Natural product library)147.173861.51821
SGTC_2887904478458.44 μM0.4313736465546Chembridge (Drug-like library)323.4322.98313fatty acid desaturase (OLE1)
SGTC_1831st05532812 μM0.4285711103068TimTec (Natural product derivative library)367.48615.52112heme biosynthesis & mitochondrial translocase
SGTC_2893904848825.97 μM0.4150946467338Chembridge (Drug-like library)337.458583.46913fatty acid desaturase (OLE1)