st054113

5-nitro-7-[(4-phenylpiperazin-1-yl)methyl]quinolin-8-ol

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1832
Screen concentration 55.0 μM
Source TimTec (Natural product derivative library)
PubChem CID 1251267
SMILES C1CN(CCN1CC2=CC(=C3C=CC=NC3=C2O)[N+](=O)[O-])C4=CC=CC=C4
Standardized SMILES Oc1c(CN2CCN(CC2)c3ccccc3)cc(c4cccnc14)[N+](=O)[O-]
Molecular weight 364.3978
ALogP 3.37
H-bond donor count 1
H-bond acceptor count 6
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.27
% growth inhibition (Hom. pool) 0


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 1251267
Download HIP data (tab-delimited text)  (excel)
Gene:DIB1(YPR082C)|FD-Score:-3.39|P-value:3.54E-4|Clearance:0||SGD DESC:17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein Gene:DIM1(YPL266W)|FD-Score:3.13|P-value:8.70E-4|Clearance:0.02||SGD DESC:Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing Gene:FAD1(YDL045C)|FD-Score:-3.34|P-value:4.17E-4|Clearance:0||SGD DESC:Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin Gene:KEI1(YDR367W)|FD-Score:4.24|P-value:1.10E-5|Clearance:0.64||SGD DESC:Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene Gene:LSG1(YGL099W)|FD-Score:3.42|P-value:3.13E-4|Clearance:0.26||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MCM6(YGL201C)|FD-Score:4.15|P-value:1.68E-5|Clearance:0.64||SGD DESC:Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p Gene:MPP10(YJR002W)|FD-Score:3.16|P-value:7.79E-4|Clearance:0.02||SGD DESC:Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p Gene:NOG2(YNR053C)|FD-Score:4.06|P-value:2.44E-5|Clearance:0.64||SGD DESC:Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation Gene:NUP192(YJL039C)|FD-Score:3.15|P-value:8.22E-4|Clearance:0.02||SGD DESC:Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205 Gene:SPC98(YNL126W)|FD-Score:4.88|P-value:5.42E-7|Clearance:0.64||SGD DESC:Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque Gene:YKL036C(YKL036C_d)|FD-Score:-3.16|P-value:7.84E-4|Clearance:0||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W Gene:YLR198C(YLR198C_d)|FD-Score:3.11|P-value:9.23E-4|Clearance:0.07||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W Gene:YPD1(YDL235C)|FD-Score:-3.36|P-value:3.95E-4|Clearance:0||SGD DESC:Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus Gene:DIB1(YPR082C)|FD-Score:-3.39|P-value:3.54E-4|Clearance:0||SGD DESC:17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein Gene:DIM1(YPL266W)|FD-Score:3.13|P-value:8.70E-4|Clearance:0.02||SGD DESC:Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing Gene:FAD1(YDL045C)|FD-Score:-3.34|P-value:4.17E-4|Clearance:0||SGD DESC:Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin Gene:KEI1(YDR367W)|FD-Score:4.24|P-value:1.10E-5|Clearance:0.64||SGD DESC:Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene Gene:LSG1(YGL099W)|FD-Score:3.42|P-value:3.13E-4|Clearance:0.26||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MCM6(YGL201C)|FD-Score:4.15|P-value:1.68E-5|Clearance:0.64||SGD DESC:Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p Gene:MPP10(YJR002W)|FD-Score:3.16|P-value:7.79E-4|Clearance:0.02||SGD DESC:Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p Gene:NOG2(YNR053C)|FD-Score:4.06|P-value:2.44E-5|Clearance:0.64||SGD DESC:Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation Gene:NUP192(YJL039C)|FD-Score:3.15|P-value:8.22E-4|Clearance:0.02||SGD DESC:Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205 Gene:SPC98(YNL126W)|FD-Score:4.88|P-value:5.42E-7|Clearance:0.64||SGD DESC:Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque Gene:YKL036C(YKL036C_d)|FD-Score:-3.16|P-value:7.84E-4|Clearance:0||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W Gene:YLR198C(YLR198C_d)|FD-Score:3.11|P-value:9.23E-4|Clearance:0.07||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W Gene:YPD1(YDL235C)|FD-Score:-3.36|P-value:3.95E-4|Clearance:0||SGD DESC:Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 1251267
Download HOP data (tab-delimited text)  (excel)
Gene:AIM46(YHR199C)|FD-Score:3.37|P-value:3.81E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:APL5(YPL195W)|FD-Score:3.12|P-value:8.98E-4||SGD DESC:Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function Gene:AVL9(YLR114C)|FD-Score:-3.42|P-value:3.09E-4||SGD DESC:Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:AVT1(YJR001W)|FD-Score:-4.32|P-value:7.80E-6||SGD DESC:Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:CCC2(YDR270W)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism Gene:COX7(YMR256C)|FD-Score:3.83|P-value:6.30E-5||SGD DESC:Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain Gene:CST26(YBR042C)|FD-Score:3.86|P-value:5.61E-5||SGD DESC:Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication Gene:GDS1(YOR355W)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GVP36(YIL041W)|FD-Score:-3.43|P-value:3.04E-4||SGD DESC:BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis Gene:HOR7(YMR251W-A)|FD-Score:3.46|P-value:2.74E-4||SGD DESC:Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication Gene:HUB1(YNR032C-A)|FD-Score:3.49|P-value:2.38E-4||SGD DESC:Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear Gene:IBA57(YJR122W)|FD-Score:3.24|P-value:6.01E-4||SGD DESC:Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system Gene:MRP17(YKL003C)|FD-Score:5|P-value:2.93E-7||SGD DESC:Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator Gene:MRPL4(YLR439W)|FD-Score:-3.53|P-value:2.08E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit Gene:PBA1(YLR199C)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly Gene:PEX6(YNL329C)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol Gene:PIN3(YPR154W)|FD-Score:4.02|P-value:2.88E-5||SGD DESC:Protein that induces appearance of [PIN+] prion when overproduced Gene:PMT6(YGR199W)|FD-Score:-4.86|P-value:5.73E-7||SGD DESC:Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases Gene:RTK1(YDL025C)|FD-Score:-4.03|P-value:2.81E-5||SGD DESC:Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress Gene:SBE2(YDR351W)|FD-Score:5.51|P-value:1.84E-8||SGD DESC:Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth Gene:SSN8(YNL025C)|FD-Score:3.26|P-value:5.51E-4||SGD DESC:Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance Gene:THI2(YBR240C)|FD-Score:-4.25|P-value:1.05E-5||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:UIP4(YPL186C)|FD-Score:-3.96|P-value:3.78E-5||SGD DESC:Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope Gene:URA8(YJR103W)|FD-Score:3.15|P-value:8.22E-4||SGD DESC:Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication Gene:VEL1(YGL258W)|FD-Score:4.34|P-value:7.04E-6||SGD DESC:Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C Gene:VPS71(YML041C)|FD-Score:-3.34|P-value:4.22E-4||SGD DESC:Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:YMR155W(YMR155W_p)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Gene:YNR063W(YNR063W_p)|FD-Score:6.61|P-value:1.96E-11||SGD DESC:Putative zinc-cluster protein of unknown function Gene:AIM46(YHR199C)|FD-Score:3.37|P-value:3.81E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:APL5(YPL195W)|FD-Score:3.12|P-value:8.98E-4||SGD DESC:Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function Gene:AVL9(YLR114C)|FD-Score:-3.42|P-value:3.09E-4||SGD DESC:Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:AVT1(YJR001W)|FD-Score:-4.32|P-value:7.80E-6||SGD DESC:Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:CCC2(YDR270W)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism Gene:COX7(YMR256C)|FD-Score:3.83|P-value:6.30E-5||SGD DESC:Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain Gene:CST26(YBR042C)|FD-Score:3.86|P-value:5.61E-5||SGD DESC:Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication Gene:GDS1(YOR355W)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GVP36(YIL041W)|FD-Score:-3.43|P-value:3.04E-4||SGD DESC:BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis Gene:HOR7(YMR251W-A)|FD-Score:3.46|P-value:2.74E-4||SGD DESC:Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication Gene:HUB1(YNR032C-A)|FD-Score:3.49|P-value:2.38E-4||SGD DESC:Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear Gene:IBA57(YJR122W)|FD-Score:3.24|P-value:6.01E-4||SGD DESC:Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system Gene:MRP17(YKL003C)|FD-Score:5|P-value:2.93E-7||SGD DESC:Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator Gene:MRPL4(YLR439W)|FD-Score:-3.53|P-value:2.08E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit Gene:PBA1(YLR199C)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly Gene:PEX6(YNL329C)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol Gene:PIN3(YPR154W)|FD-Score:4.02|P-value:2.88E-5||SGD DESC:Protein that induces appearance of [PIN+] prion when overproduced Gene:PMT6(YGR199W)|FD-Score:-4.86|P-value:5.73E-7||SGD DESC:Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases Gene:RTK1(YDL025C)|FD-Score:-4.03|P-value:2.81E-5||SGD DESC:Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress Gene:SBE2(YDR351W)|FD-Score:5.51|P-value:1.84E-8||SGD DESC:Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth Gene:SSN8(YNL025C)|FD-Score:3.26|P-value:5.51E-4||SGD DESC:Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance Gene:THI2(YBR240C)|FD-Score:-4.25|P-value:1.05E-5||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:UIP4(YPL186C)|FD-Score:-3.96|P-value:3.78E-5||SGD DESC:Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope Gene:URA8(YJR103W)|FD-Score:3.15|P-value:8.22E-4||SGD DESC:Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication Gene:VEL1(YGL258W)|FD-Score:4.34|P-value:7.04E-6||SGD DESC:Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C Gene:VPS71(YML041C)|FD-Score:-3.34|P-value:4.22E-4||SGD DESC:Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:YMR155W(YMR155W_p)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Gene:YNR063W(YNR063W_p)|FD-Score:6.61|P-value:1.96E-11||SGD DESC:Putative zinc-cluster protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YNL126W4.885.42E-70.64SPC98Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YDR367W4.241.10E-50.64KEI1Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
YGL201C4.151.68E-50.64MCM6Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p
YNR053C4.062.44E-50.64NOG2Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YGL099W3.423.13E-40.26LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YJR002W3.167.79E-40.02MPP10Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
YJL039C3.158.22E-40.02NUP192Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205
YPL266W3.138.70E-40.02DIM1Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
YLR198C_d3.119.23E-40.07YLR198C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
YHR197W3.040.001170.07RIX1Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene
YJL031C2.980.001460.01BET4Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
YIL142W2.970.001500.02CCT2Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YLR132C2.950.001590.00USB1Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
YPR107C2.950.001600.11YTH1Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
YDR086C2.840.002270.12SSS1Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YNR063W_p6.611.96E-11YNR063W_pPutative zinc-cluster protein of unknown function
YDR351W5.511.84E-8SBE2Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
YKL003C5.002.93E-7MRP17Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator
YGL258W4.347.04E-6VEL1Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C
YPR154W4.022.88E-5PIN3Protein that induces appearance of [PIN+] prion when overproduced
YBR042C3.865.61E-5CST26Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication
YMR256C3.836.30E-5COX7Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YMR155W_p3.691.14E-4YMR155W_pPutative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen
YNL329C3.601.61E-4PEX6AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol
YNR032C-A3.492.38E-4HUB1Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
YOR355W3.482.49E-4GDS1Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR251W-A3.462.74E-4HOR7Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication
YLR199C3.452.84E-4PBA1Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
YHR199C3.373.81E-4AIM46Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
YNL025C3.265.51E-4SSN8Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance

GO enrichment analysis for SGTC_1832
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1254.78E-22SGTC_2420aureobasidin a 50.0 nMMiscellaneous99634300.0991736
0.0945.45E-13SGTC_1828st055811 49.0 μMTimTec (Natural product derivative library)58775890.127907
0.0855.77E-11SGTC_7651319-0117 244.0 μMChemDiv (Drug-like library)34877460.0760S ribosome export
0.0813.79E-10SGTC_1350933-0004 26.3 μMChemDiv (Drug-like library)212306170.073170760S ribosome export
0.0813.85E-10SGTC_2567aureobasidin a 60.0 nMMiscellaneous99634300.0991736
0.0808.44E-10SGTC_618k072-0232 33.2 μMChemDiv (Drug-like library)58727560.11538560S ribosome export
0.0758.96E-9SGTC_2692st077426 47.7 μMTimTec (Natural product derivative library)252385710.0606061
0.0714.51E-8SGTC_9761348-1067 47.6 μMChemDiv (Drug-like library)53106710.11688360S ribosome export
0.0707.68E-8SGTC_490717-0965 32.1 μMChemDiv (Drug-like library)58893490.18181860S ribosome export
0.0681.94E-7SGTC_22067254556 147.0 μMChembridge (Fragment library)43989050.075949460S ribosome export
0.0672.14E-7SGTC_13651672-3266 55.4 μMChemDiv (Drug-like library)64158730.0947368
0.0673.13E-7SGTC_2970986-0032 24.0 μMChemDiv (Drug-like library)28474250.090909160S ribosome export
0.0663.83E-7SGTC_28097964133 13.0 μMChembridge (Drug-like library)12536650.12643760S ribosome export
0.0656.09E-7SGTC_8103825-7150 143.0 μMChemDiv (Drug-like library)223304110.10465160S ribosome export
0.0631.53E-6SGTC_24595811157 9.2 μMMiscellaneous28706840.138889mitochondrial processes

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1640st00907866.4 μM0.590164690618TimTec (Natural product derivative library)301.340362.91115
SGTC_2784756767372.73 μM0.53471247Chembridge (Drug-like library)343.42011.29616iron homeostasis
SGTC_13963511-000798.6 μM0.485294X1396ChemDiv (Drug-like library)421.843265.08441mitochondrial processes
SGTC_1637st00792417.4 μM0.460317683336TimTec (Natural product derivative library)290.787863.68113
SGTC_12981079-1278263 μM0.4590162840950ChemDiv (Drug-like library)304.258181.65507DNA damage response
SGTC_1962st07659564.5 μM0.4279619TimTec (Natural product derivative library)242.316222.76513redox potentiating
SGTC_20505263056171 μM0.392857763468Chembridge (Fragment library)268.35353.29113fatty acid desaturase (OLE1)
SGTC_3128912769149.47 μM0.33333341316314Chembridge (Drug-like library)338.426722.32815
SGTC_2816798270658.44 μM0.3150682981853Chembridge (Drug-like library)326.392883.50115azole & statin
SGTC_1463448-865053.13 μM0.2948722891488ChemDiv (Drug-like library)449.34153.82226NEO1-PIK1