Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDL018C | 5.97 | 1.18E-9 | ERP3 | Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport |
YBR251W | 5.50 | 1.85E-8 | MRPS5 | Mitochondrial ribosomal protein of the small subunit |
YBL010C_p | 4.87 | 5.59E-7 | YBL010C_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles |
YMR022W | 4.87 | 5.65E-7 | UBC7 | Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly |
YHL002W | 4.77 | 9.06E-7 | HSE1 | Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes |
YKL156W | 4.36 | 6.48E-6 | RPS27A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
YOL006C | 4.32 | 7.92E-6 | TOP1 | Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination |
YJR110W | 4.28 | 9.55E-6 | YMR1 | Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family |
YDR451C | 4.24 | 1.12E-5 | YHP1 | Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication |
YCR105W | 4.23 | 1.18E-5 | ADH7 | NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance |
YOL020W | 4.18 | 1.46E-5 | TAT2 | High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance |
YBL089W | 4.12 | 1.88E-5 | AVT5 | Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication |
YML053C_p | 4.12 | 1.91E-5 | YML053C_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene |
YER047C | 4.01 | 3.01E-5 | SAP1 | Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system |
YNR023W | 3.99 | 3.37E-5 | SNF12 | 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive |