st055362

3-(3,4-dihydroxyphenyl)benzo[f]chromen-1-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1842
Screen concentration 61.2 μM
Source TimTec (Natural product derivative library)
PubChem CID 676032
SMILES C1=CC=C2C(=C1)C=CC3=C2C(=O)C=C(O3)C4=CC(=C(C=C4)O)O
Standardized SMILES Oc1ccc(cc1O)C2=CC(=O)c3c(O2)ccc4ccccc34
Molecular weight 304.2962
ALogP 3.56
H-bond donor count 2
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.75
% growth inhibition (Hom. pool) -1.28


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 676032
Download HIP data (tab-delimited text)  (excel)
Gene:ENP2(YGR145W)|FD-Score:4.73|P-value:1.12E-6|Clearance:0.61||SGD DESC:Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p Gene:FAD1(YDL045C)|FD-Score:4.06|P-value:2.44E-5|Clearance:0.3||SGD DESC:Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin Gene:FHL1(YPR104C)|FD-Score:3.32|P-value:4.52E-4|Clearance:0.26||SGD DESC:Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants Gene:MCM6(YGL201C)|FD-Score:4.12|P-value:1.92E-5|Clearance:0.06||SGD DESC:Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p Gene:NOP14(YDL148C)|FD-Score:-3.33|P-value:4.40E-4|Clearance:0||SGD DESC:Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA Gene:ROT1(YMR200W)|FD-Score:-3.19|P-value:7.13E-4|Clearance:0||SGD DESC:Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation Gene:YTM1(YOR272W)|FD-Score:3.76|P-value:8.53E-5|Clearance:0.44||SGD DESC:Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats Gene:ENP2(YGR145W)|FD-Score:4.73|P-value:1.12E-6|Clearance:0.61||SGD DESC:Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p Gene:FAD1(YDL045C)|FD-Score:4.06|P-value:2.44E-5|Clearance:0.3||SGD DESC:Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin Gene:FHL1(YPR104C)|FD-Score:3.32|P-value:4.52E-4|Clearance:0.26||SGD DESC:Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants Gene:MCM6(YGL201C)|FD-Score:4.12|P-value:1.92E-5|Clearance:0.06||SGD DESC:Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p Gene:NOP14(YDL148C)|FD-Score:-3.33|P-value:4.40E-4|Clearance:0||SGD DESC:Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA Gene:ROT1(YMR200W)|FD-Score:-3.19|P-value:7.13E-4|Clearance:0||SGD DESC:Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation Gene:YTM1(YOR272W)|FD-Score:3.76|P-value:8.53E-5|Clearance:0.44||SGD DESC:Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 676032
Download HOP data (tab-delimited text)  (excel)
Gene:ADH7(YCR105W)|FD-Score:4.23|P-value:1.18E-5||SGD DESC:NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance Gene:AIM46(YHR199C)|FD-Score:3.34|P-value:4.16E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:AVT5(YBL089W)|FD-Score:4.12|P-value:1.88E-5||SGD DESC:Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication Gene:BFA1(YJR053W)|FD-Score:-4.24|P-value:1.10E-5||SGD DESC:Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis Gene:CAT2(YML042W)|FD-Score:3.46|P-value:2.67E-4||SGD DESC:Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes Gene:CDH1(YGL003C)|FD-Score:-3.46|P-value:2.74E-4||SGD DESC:Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p Gene:CIT2(YCR005C)|FD-Score:3.1|P-value:9.58E-4||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication Gene:COX18(YGR062C)|FD-Score:-3.2|P-value:6.84E-4||SGD DESC:Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC Gene:DAL3(YIR032C)|FD-Score:3.74|P-value:9.25E-5||SGD DESC:Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression Gene:DAL5(YJR152W)|FD-Score:3.19|P-value:7.06E-4||SGD DESC:Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression Gene:DTR1(YBR180W)|FD-Score:3.17|P-value:7.57E-4||SGD DESC:Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation Gene:EAF5(YEL018W)|FD-Score:3.18|P-value:7.30E-4||SGD DESC:Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex Gene:ERP3(YDL018C)|FD-Score:5.97|P-value:1.18E-9||SGD DESC:Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport Gene:EST1(YLR233C)|FD-Score:-7.17|P-value:3.88E-13||SGD DESC:TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA Gene:ETR1(YBR026C)|FD-Score:3.22|P-value:6.43E-4||SGD DESC:2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis Gene:FCY22(YER060W-A)|FD-Score:3.14|P-value:8.42E-4||SGD DESC:Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function Gene:HSE1(YHL002W)|FD-Score:4.77|P-value:9.06E-7||SGD DESC:Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes Gene:IKI3(YLR384C)|FD-Score:-4.26|P-value:1.01E-5||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) Gene:IRA2(YOL081W)|FD-Score:-3.19|P-value:7.03E-4||SGD DESC:GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication Gene:KAR9(YPL269W)|FD-Score:3.86|P-value:5.63E-5||SGD DESC:Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase Gene:MMT1(YMR177W)|FD-Score:3.12|P-value:8.93E-4||SGD DESC:Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p Gene:MRP17(YKL003C)|FD-Score:-3.29|P-value:5.08E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator Gene:MRPL17(YNL252C)|FD-Score:-3.2|P-value:6.80E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS5(YBR251W)|FD-Score:5.5|P-value:1.85E-8||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSG5(YNL053W)|FD-Score:3.61|P-value:1.52E-4||SGD DESC:Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p Gene:MSR1(YHR091C)|FD-Score:-4.31|P-value:8.21E-6||SGD DESC:Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 Gene:MVP1(YMR004W)|FD-Score:3.14|P-value:8.43E-4||SGD DESC:Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress Gene:OSW2(YLR054C)|FD-Score:3.28|P-value:5.22E-4||SGD DESC:Protein of unknown function proposed to be involved in the assembly of the spore wall Gene:PMT5(YDL093W)|FD-Score:3.36|P-value:3.95E-4||SGD DESC:Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals Gene:PTC5(YOR090C)|FD-Score:3.65|P-value:1.30E-4||SGD DESC:Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p Gene:RCN2(YOR220W_p)|FD-Score:3.64|P-value:1.36E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress Gene:RDS2(YPL133C)|FD-Score:3.28|P-value:5.15E-4||SGD DESC:Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole Gene:REI1(YBR267W)|FD-Score:-4.91|P-value:4.47E-7||SGD DESC:Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network Gene:RMD6(YEL072W)|FD-Score:3.39|P-value:3.45E-4||SGD DESC:Protein required for sporulation Gene:RPA49(YNL248C)|FD-Score:-3.55|P-value:1.91E-4||SGD DESC:RNA polymerase I subunit A49 Gene:RPL34A(YER056C-A)|FD-Score:-3.35|P-value:4.10E-4||SGD DESC:Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication Gene:RPS10A(YOR293W)|FD-Score:-3.22|P-value:6.39E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication Gene:RPS27A(YKL156W)|FD-Score:4.36|P-value:6.48E-6||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RTG3(YBL103C)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways Gene:SAP1(YER047C)|FD-Score:4.01|P-value:3.01E-5||SGD DESC:Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system Gene:SBE22(YHR103W)|FD-Score:-3.95|P-value:3.98E-5||SGD DESC:Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth Gene:SNF12(YNR023W)|FD-Score:3.99|P-value:3.37E-5||SGD DESC:73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive Gene:SSQ1(YLR369W)|FD-Score:-3.68|P-value:1.19E-4||SGD DESC:Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia Gene:STB4(YMR019W)|FD-Score:3.4|P-value:3.43E-4||SGD DESC:Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay; Gene:TAT2(YOL020W)|FD-Score:4.18|P-value:1.46E-5||SGD DESC:High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance Gene:TED1(YIL039W)|FD-Score:-3.75|P-value:8.97E-5||SGD DESC:Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:THI4(YGR144W)|FD-Score:3.48|P-value:2.46E-4||SGD DESC:Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents Gene:THI7(YLR237W)|FD-Score:3.09|P-value:9.92E-4||SGD DESC:Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia Gene:TOP1(YOL006C)|FD-Score:4.32|P-value:7.92E-6||SGD DESC:Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination Gene:UBA3(YPR066W)|FD-Score:3.43|P-value:3.07E-4||SGD DESC:Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern Gene:UBC7(YMR022W)|FD-Score:4.87|P-value:5.65E-7||SGD DESC:Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly Gene:UBR2(YLR024C)|FD-Score:-4.73|P-value:1.10E-6||SGD DESC:Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex Gene:YBL010C(YBL010C_p)|FD-Score:4.87|P-value:5.59E-7||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles Gene:YBL044W(YBL044W_p)|FD-Score:3.89|P-value:5.00E-5||SGD DESC:Putative protein of unknown function; YBL044W is not an essential protein Gene:YDR215C(YDR215C_d)|FD-Score:3.2|P-value:6.96E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein Gene:YHL045W(YHL045W_d)|FD-Score:3.16|P-value:7.90E-4||SGD DESC:Putative protein of unknown function; not an essential gene Gene:YHP1(YDR451C)|FD-Score:4.24|P-value:1.12E-5||SGD DESC:Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication Gene:YIL060W(YIL060W_p)|FD-Score:-4.87|P-value:5.54E-7||SGD DESC:Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene Gene:YIL108W(YIL108W_p)|FD-Score:-3.78|P-value:7.75E-5||SGD DESC:Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress Gene:YJL007C(YJL007C_d)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJL064W(YJL064W_d)|FD-Score:-3.39|P-value:3.53E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 Gene:YLR012C(YLR012C_p)|FD-Score:-3.2|P-value:6.84E-4||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YML053C(YML053C_p)|FD-Score:4.12|P-value:1.91E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene Gene:YMR1(YJR110W)|FD-Score:4.28|P-value:9.55E-6||SGD DESC:Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family Gene:YNL143C(YNL143C_p)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YNR063W(YNR063W_p)|FD-Score:3.34|P-value:4.18E-4||SGD DESC:Putative zinc-cluster protein of unknown function Gene:YPL068C(YPL068C_p)|FD-Score:-3.19|P-value:7.17E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YPR1(YDR368W)|FD-Score:-3.28|P-value:5.11E-4||SGD DESC:NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication Gene:YPT11(YNL304W)|FD-Score:3.24|P-value:6.00E-4||SGD DESC:Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells Gene:ADH7(YCR105W)|FD-Score:4.23|P-value:1.18E-5||SGD DESC:NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance Gene:AIM46(YHR199C)|FD-Score:3.34|P-value:4.16E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:AVT5(YBL089W)|FD-Score:4.12|P-value:1.88E-5||SGD DESC:Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication Gene:BFA1(YJR053W)|FD-Score:-4.24|P-value:1.10E-5||SGD DESC:Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis Gene:CAT2(YML042W)|FD-Score:3.46|P-value:2.67E-4||SGD DESC:Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes Gene:CDH1(YGL003C)|FD-Score:-3.46|P-value:2.74E-4||SGD DESC:Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p Gene:CIT2(YCR005C)|FD-Score:3.1|P-value:9.58E-4||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication Gene:COX18(YGR062C)|FD-Score:-3.2|P-value:6.84E-4||SGD DESC:Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC Gene:DAL3(YIR032C)|FD-Score:3.74|P-value:9.25E-5||SGD DESC:Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression Gene:DAL5(YJR152W)|FD-Score:3.19|P-value:7.06E-4||SGD DESC:Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression Gene:DTR1(YBR180W)|FD-Score:3.17|P-value:7.57E-4||SGD DESC:Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation Gene:EAF5(YEL018W)|FD-Score:3.18|P-value:7.30E-4||SGD DESC:Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex Gene:ERP3(YDL018C)|FD-Score:5.97|P-value:1.18E-9||SGD DESC:Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport Gene:EST1(YLR233C)|FD-Score:-7.17|P-value:3.88E-13||SGD DESC:TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA Gene:ETR1(YBR026C)|FD-Score:3.22|P-value:6.43E-4||SGD DESC:2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis Gene:FCY22(YER060W-A)|FD-Score:3.14|P-value:8.42E-4||SGD DESC:Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function Gene:HSE1(YHL002W)|FD-Score:4.77|P-value:9.06E-7||SGD DESC:Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes Gene:IKI3(YLR384C)|FD-Score:-4.26|P-value:1.01E-5||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) Gene:IRA2(YOL081W)|FD-Score:-3.19|P-value:7.03E-4||SGD DESC:GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication Gene:KAR9(YPL269W)|FD-Score:3.86|P-value:5.63E-5||SGD DESC:Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase Gene:MMT1(YMR177W)|FD-Score:3.12|P-value:8.93E-4||SGD DESC:Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p Gene:MRP17(YKL003C)|FD-Score:-3.29|P-value:5.08E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator Gene:MRPL17(YNL252C)|FD-Score:-3.2|P-value:6.80E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS5(YBR251W)|FD-Score:5.5|P-value:1.85E-8||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSG5(YNL053W)|FD-Score:3.61|P-value:1.52E-4||SGD DESC:Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p Gene:MSR1(YHR091C)|FD-Score:-4.31|P-value:8.21E-6||SGD DESC:Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 Gene:MVP1(YMR004W)|FD-Score:3.14|P-value:8.43E-4||SGD DESC:Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress Gene:OSW2(YLR054C)|FD-Score:3.28|P-value:5.22E-4||SGD DESC:Protein of unknown function proposed to be involved in the assembly of the spore wall Gene:PMT5(YDL093W)|FD-Score:3.36|P-value:3.95E-4||SGD DESC:Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals Gene:PTC5(YOR090C)|FD-Score:3.65|P-value:1.30E-4||SGD DESC:Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p Gene:RCN2(YOR220W_p)|FD-Score:3.64|P-value:1.36E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress Gene:RDS2(YPL133C)|FD-Score:3.28|P-value:5.15E-4||SGD DESC:Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole Gene:REI1(YBR267W)|FD-Score:-4.91|P-value:4.47E-7||SGD DESC:Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network Gene:RMD6(YEL072W)|FD-Score:3.39|P-value:3.45E-4||SGD DESC:Protein required for sporulation Gene:RPA49(YNL248C)|FD-Score:-3.55|P-value:1.91E-4||SGD DESC:RNA polymerase I subunit A49 Gene:RPL34A(YER056C-A)|FD-Score:-3.35|P-value:4.10E-4||SGD DESC:Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication Gene:RPS10A(YOR293W)|FD-Score:-3.22|P-value:6.39E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication Gene:RPS27A(YKL156W)|FD-Score:4.36|P-value:6.48E-6||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RTG3(YBL103C)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways Gene:SAP1(YER047C)|FD-Score:4.01|P-value:3.01E-5||SGD DESC:Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system Gene:SBE22(YHR103W)|FD-Score:-3.95|P-value:3.98E-5||SGD DESC:Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth Gene:SNF12(YNR023W)|FD-Score:3.99|P-value:3.37E-5||SGD DESC:73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive Gene:SSQ1(YLR369W)|FD-Score:-3.68|P-value:1.19E-4||SGD DESC:Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia Gene:STB4(YMR019W)|FD-Score:3.4|P-value:3.43E-4||SGD DESC:Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay; Gene:TAT2(YOL020W)|FD-Score:4.18|P-value:1.46E-5||SGD DESC:High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance Gene:TED1(YIL039W)|FD-Score:-3.75|P-value:8.97E-5||SGD DESC:Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:THI4(YGR144W)|FD-Score:3.48|P-value:2.46E-4||SGD DESC:Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents Gene:THI7(YLR237W)|FD-Score:3.09|P-value:9.92E-4||SGD DESC:Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia Gene:TOP1(YOL006C)|FD-Score:4.32|P-value:7.92E-6||SGD DESC:Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination Gene:UBA3(YPR066W)|FD-Score:3.43|P-value:3.07E-4||SGD DESC:Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern Gene:UBC7(YMR022W)|FD-Score:4.87|P-value:5.65E-7||SGD DESC:Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly Gene:UBR2(YLR024C)|FD-Score:-4.73|P-value:1.10E-6||SGD DESC:Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex Gene:YBL010C(YBL010C_p)|FD-Score:4.87|P-value:5.59E-7||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles Gene:YBL044W(YBL044W_p)|FD-Score:3.89|P-value:5.00E-5||SGD DESC:Putative protein of unknown function; YBL044W is not an essential protein Gene:YDR215C(YDR215C_d)|FD-Score:3.2|P-value:6.96E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein Gene:YHL045W(YHL045W_d)|FD-Score:3.16|P-value:7.90E-4||SGD DESC:Putative protein of unknown function; not an essential gene Gene:YHP1(YDR451C)|FD-Score:4.24|P-value:1.12E-5||SGD DESC:Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication Gene:YIL060W(YIL060W_p)|FD-Score:-4.87|P-value:5.54E-7||SGD DESC:Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene Gene:YIL108W(YIL108W_p)|FD-Score:-3.78|P-value:7.75E-5||SGD DESC:Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress Gene:YJL007C(YJL007C_d)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJL064W(YJL064W_d)|FD-Score:-3.39|P-value:3.53E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 Gene:YLR012C(YLR012C_p)|FD-Score:-3.2|P-value:6.84E-4||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YML053C(YML053C_p)|FD-Score:4.12|P-value:1.91E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene Gene:YMR1(YJR110W)|FD-Score:4.28|P-value:9.55E-6||SGD DESC:Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family Gene:YNL143C(YNL143C_p)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YNR063W(YNR063W_p)|FD-Score:3.34|P-value:4.18E-4||SGD DESC:Putative zinc-cluster protein of unknown function Gene:YPL068C(YPL068C_p)|FD-Score:-3.19|P-value:7.17E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YPR1(YDR368W)|FD-Score:-3.28|P-value:5.11E-4||SGD DESC:NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication Gene:YPT11(YNL304W)|FD-Score:3.24|P-value:6.00E-4||SGD DESC:Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGR145W4.731.12E-60.61ENP2Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
YGL201C4.121.92E-50.06MCM6Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p
YDL045C4.062.44E-50.30FAD1Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
YOR272W3.768.53E-50.44YTM1Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
YPR104C3.324.52E-40.26FHL1Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
YPL063W3.060.001110.04TIM50Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
YOR074C3.020.001250.28CDC21Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
YGR147C2.750.003010.06NAT2Protein with an apparent role in acetylation of N-terminal methionine residues
YNL152W2.680.003630.06INN1Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
YER082C2.620.004350.09UTP7Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YPR016C2.530.005710.01TIF6Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
YDL016C_d2.520.005840.02YDL016C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication
YIR015W2.500.006200.11RPR2Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress
YBL020W2.390.008500.04RFT1Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
YOL097C2.340.009540.00WRS1Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDL018C5.971.18E-9ERP3Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
YBR251W5.501.85E-8MRPS5Mitochondrial ribosomal protein of the small subunit
YBL010C_p4.875.59E-7YBL010C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
YMR022W4.875.65E-7UBC7Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
YHL002W4.779.06E-7HSE1Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
YKL156W4.366.48E-6RPS27AProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
YOL006C4.327.92E-6TOP1Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
YJR110W4.289.55E-6YMR1Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family
YDR451C4.241.12E-5YHP1Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication
YCR105W4.231.18E-5ADH7NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YOL020W4.181.46E-5TAT2High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance
YBL089W4.121.88E-5AVT5Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication
YML053C_p4.121.91E-5YML053C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
YER047C4.013.01E-5SAP1Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
YNR023W3.993.37E-5SNF1273 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive

GO enrichment analysis for SGTC_1842
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1031.67E-15SGTC_1838st055369 84.5 μMTimTec (Natural product derivative library)6760360.272727
0.1025.90E-15SGTC_249418-aminoabieta-8,11,13-triene sulfate 3.7 μMMicrosource (Natural product library)167250760.0519481
0.0831.77E-10SGTC_30239089636 49.5 μMChembridge (Drug-like library)172492410.0759494
0.0663.67E-7SGTC_1831st055328 12.0 μMTimTec (Natural product derivative library)11030680.106061heme biosynthesis & mitochondrial translocase
0.0664.62E-7SGTC_30229087993 49.5 μMChembridge (Drug-like library)171736440.103896
0.0655.53E-7SGTC_60844-0013 19.8 μMChemDiv (Drug-like library)15849000.136364
0.0648.73E-7SGTC_820054-0107 293.8 μMChemDiv (Drug-like library)31046970.0714286
0.0631.47E-6SGTC_2654protoveratrine a 100.0 μMMicrosource (Natural product library)57022780.0243902
0.0543.58E-5SGTC_20185133068 143.0 μMChembridge (Fragment library)7853620.0746269
0.0534.71E-5SGTC_4260988-0037 14.6 μMChemDiv (Drug-like library)53830080.169231ERAD & cell cycle
0.0534.93E-5SGTC_1065prochlorperazine maleate 2.5 μMNIH Clinical Collection64360570.08
0.0519.42E-5SGTC_760433-0009 400.3 μMChemDiv (Drug-like library)28415690.0721649
0.0511.02E-4SGTC_13281441-0025 69.2 μMChemDiv (Drug-like library)45626010.0857143
0.0501.09E-4SGTC_31929110362 49.5 μMChembridge (Drug-like library)166494800.157895mitochondrial processes
0.0501.21E-4SGTC_1026k007-1105 30.6 μMChemDiv (Drug-like library)70667940.0555556ERAD & cell cycle

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_1859st05599820 μM0.744186676301TimTec (Natural product derivative library)288.296783.80213
SGTC_15324',5'-dihydroxyflavone78.7 μM0.479167165521TimTec (Pure natural product library)254.23752.65224Golgi
SGTC_18903',4',7',8'-tetrahydroxyflavone14.9 μM0.469388688798TimTec (Natural product derivative library)286.23632.16846
SGTC_2513baicalein25.65 μM0.4693885281605Microsource (Natural product library)270.23692.4135calcium & mitochondrial duress
SGTC_2515chrysin20.77 μM0.4693885281607Microsource (Natural product library)254.23752.65224RPP1 & pyrimidine depletion
SGTC_1529apigenin74 μM0.448985280443TimTec (Pure natural product library)270.23692.4135
SGTC_2568diosmetin100 μM0.4363645281612Microsource (Natural product library)300.262882.39436
SGTC_18943',6'-dihydroxyflavone78.7 μM0.411765688662TimTec (Natural product derivative library)254.23752.65224
SGTC_2636apigenin dimethyl ether100 μM0.4074075281601Microsource (Natural product library)298.290062.86115
SGTC_1834st05598152.8 μM0.4471719TimTec (Natural product derivative library)284.263482.63625RPP1 & pyrimidine depletion