| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YOL150C_d | 9.27 | 9.29E-21 | YOL150C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YCR065W | 6.56 | 2.75E-11 | HCM1 | Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role |
| YFR030W | 5.41 | 3.22E-8 | MET10 | Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide |
| YOR226C | 4.88 | 5.27E-7 | ISU2 | Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved |
| YLR131C | 4.67 | 1.48E-6 | ACE2 | Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication |
| YDR277C | 4.43 | 4.80E-6 | MTH1 | Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation |
| YER121W_p | 4.25 | 1.08E-5 | YER121W_p | Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy |
| YBR133C | 4.24 | 1.13E-5 | HSL7 | Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress |
| YHR207C | 3.98 | 3.52E-5 | SET5 | Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus |
| YML099C | 3.89 | 5.02E-5 | ARG81 | Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p |
| YIL030C | 3.82 | 6.71E-5 | SSM4 | Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation |
| YKR033C_d | 3.77 | 8.30E-5 | YKR033C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80 |
| YPR114W_p | 3.74 | 9.03E-5 | YPR114W_p | Putative protein of unknown function |
| YBL005W | 3.69 | 1.11E-4 | PDR3 | Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
| YGR107W_d | 3.69 | 1.12E-4 | YGR107W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
