3455-3465

2-iodo-5-[(4-methylphenyl)methyl]pyridin-3-ol

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_186
Screen concentration 67.3 μM
Source ChemDiv (Drug-like library)
PubChem CID 755278
SMILES CC1=CC=C(C=C1)CC2=CC(=C(N=C2)I)O
Standardized SMILES Cc1ccc(Cc2cnc(I)c(O)c2)cc1
Molecular weight 325.145
ALogP 4
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 16.73
% growth inhibition (Hom. pool) 14.67


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 755278
Download HIP data (tab-delimited text)  (excel)
Gene:AVO1(YOL078W)|FD-Score:4.75|P-value:1.01E-6|Clearance:0.61||SGD DESC:Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth Gene:CIA1(YDR267C)|FD-Score:-3.2|P-value:6.80E-4|Clearance:0||SGD DESC:Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein Gene:CWC2(YDL209C)|FD-Score:-3.8|P-value:7.18E-5|Clearance:0||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2 Gene:FRS1(YLR060W)|FD-Score:-3.78|P-value:7.79E-5|Clearance:0||SGD DESC:Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control Gene:GCD11(YER025W)|FD-Score:-4.2|P-value:1.34E-5|Clearance:0||SGD DESC:Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met Gene:JIP5(YPR169W)|FD-Score:3.24|P-value:5.95E-4|Clearance:0.2||SGD DESC:Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein Gene:KRI1(YNL308C)|FD-Score:-4.12|P-value:1.93E-5|Clearance:0||SGD DESC:Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p Gene:RER2(YBR002C)|FD-Score:7.88|P-value:1.69E-15|Clearance:3.13||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RIM2(YBR192W)|FD-Score:4.14|P-value:1.75E-5|Clearance:0.64||SGD DESC:Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family Gene:RPT2(YDL007W)|FD-Score:3.5|P-value:2.34E-4|Clearance:0.15||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle Gene:TAF11(YML015C)|FD-Score:3.35|P-value:4.05E-4|Clearance:0.06||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:YOR102W(YOR102W_d)|FD-Score:-3.45|P-value:2.80E-4|Clearance:0||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex Gene:YTM1(YOR272W)|FD-Score:3.29|P-value:5.05E-4|Clearance:0.05||SGD DESC:Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats Gene:AVO1(YOL078W)|FD-Score:4.75|P-value:1.01E-6|Clearance:0.61||SGD DESC:Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth Gene:CIA1(YDR267C)|FD-Score:-3.2|P-value:6.80E-4|Clearance:0||SGD DESC:Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein Gene:CWC2(YDL209C)|FD-Score:-3.8|P-value:7.18E-5|Clearance:0||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2 Gene:FRS1(YLR060W)|FD-Score:-3.78|P-value:7.79E-5|Clearance:0||SGD DESC:Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control Gene:GCD11(YER025W)|FD-Score:-4.2|P-value:1.34E-5|Clearance:0||SGD DESC:Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met Gene:JIP5(YPR169W)|FD-Score:3.24|P-value:5.95E-4|Clearance:0.2||SGD DESC:Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein Gene:KRI1(YNL308C)|FD-Score:-4.12|P-value:1.93E-5|Clearance:0||SGD DESC:Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p Gene:RER2(YBR002C)|FD-Score:7.88|P-value:1.69E-15|Clearance:3.13||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RIM2(YBR192W)|FD-Score:4.14|P-value:1.75E-5|Clearance:0.64||SGD DESC:Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family Gene:RPT2(YDL007W)|FD-Score:3.5|P-value:2.34E-4|Clearance:0.15||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle Gene:TAF11(YML015C)|FD-Score:3.35|P-value:4.05E-4|Clearance:0.06||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:YOR102W(YOR102W_d)|FD-Score:-3.45|P-value:2.80E-4|Clearance:0||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex Gene:YTM1(YOR272W)|FD-Score:3.29|P-value:5.05E-4|Clearance:0.05||SGD DESC:Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 755278
Download HOP data (tab-delimited text)  (excel)
Gene:ATP3(YBR039W)|FD-Score:3.32|P-value:4.58E-4||SGD DESC:Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Gene:CCM1(YGR150C)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport Gene:CUL3(YGR003W)|FD-Score:3.43|P-value:3.06E-4||SGD DESC:Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3 Gene:MRPL23(YOR150W)|FD-Score:3.18|P-value:7.46E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS12(YNR036C)|FD-Score:3.23|P-value:6.12E-4||SGD DESC:Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins Gene:PET54(YGR222W)|FD-Score:3.74|P-value:9.10E-5||SGD DESC:Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing Gene:PMT2(YAL023C)|FD-Score:-3.38|P-value:3.58E-4||SGD DESC:Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication Gene:RPL23B(YER117W)|FD-Score:-3.79|P-value:7.52E-5||SGD DESC:Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication Gene:RRG9(YNL213C)|FD-Score:3.57|P-value:1.76E-4||SGD DESC:Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:TOP1(YOL006C)|FD-Score:-3.15|P-value:8.10E-4||SGD DESC:Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination Gene:TUF1(YOR187W)|FD-Score:4.17|P-value:1.55E-5||SGD DESC:Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans Gene:YNL184C(YNL184C_p)|FD-Score:3.1|P-value:9.60E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:ATP3(YBR039W)|FD-Score:3.32|P-value:4.58E-4||SGD DESC:Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Gene:CCM1(YGR150C)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport Gene:CUL3(YGR003W)|FD-Score:3.43|P-value:3.06E-4||SGD DESC:Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3 Gene:MRPL23(YOR150W)|FD-Score:3.18|P-value:7.46E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS12(YNR036C)|FD-Score:3.23|P-value:6.12E-4||SGD DESC:Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins Gene:PET54(YGR222W)|FD-Score:3.74|P-value:9.10E-5||SGD DESC:Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing Gene:PMT2(YAL023C)|FD-Score:-3.38|P-value:3.58E-4||SGD DESC:Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication Gene:RPL23B(YER117W)|FD-Score:-3.79|P-value:7.52E-5||SGD DESC:Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication Gene:RRG9(YNL213C)|FD-Score:3.57|P-value:1.76E-4||SGD DESC:Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:TOP1(YOL006C)|FD-Score:-3.15|P-value:8.10E-4||SGD DESC:Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination Gene:TUF1(YOR187W)|FD-Score:4.17|P-value:1.55E-5||SGD DESC:Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans Gene:YNL184C(YNL184C_p)|FD-Score:3.1|P-value:9.60E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YBR002C7.881.69E-153.13RER2Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YOL078W4.751.01E-60.61AVO1Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YBR192W4.141.75E-50.64RIM2Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
YDL007W3.502.34E-40.15RPT2One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
YML015C3.354.05E-40.06TAF11TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors
YOR272W3.295.05E-40.05YTM1Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
YPR169W3.245.95E-40.20JIP5Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein
YBR004C3.050.001160.04GPI18Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria
YBL030C3.000.001340.00PET9Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication
YJL156C3.000.001360.06SSY5Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p
YHR058C2.940.001670.03MED6Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress
YIL026C2.910.001810.08IRR1Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
YDR044W2.830.002290.05HEM13Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YLR317W_d2.780.002680.07YLR317W_dDubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
YOL022C2.720.003290.03TSR4Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR187W4.171.55E-5TUF1Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans
YGR222W3.749.10E-5PET54Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing
YNL213C3.571.76E-4RRG9Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR003W3.433.06E-4CUL3Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3
YGR150C3.354.08E-4CCM1Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
YBR039W3.324.58E-4ATP3Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YNR036C3.236.12E-4MRPS12Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins
YOR150W3.187.46E-4MRPL23Mitochondrial ribosomal protein of the large subunit
YNL184C_p3.109.60E-4YNL184C_pProtein of unknown function; expressed at both mRNA and protein levels
YDR237W3.030.00124MRPL7Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
YDR262W_p3.010.00129YDR262W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
YJR144W2.970.00147MGM101Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage
YDR026C2.880.00201NSI1RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication
YKL121W_p2.870.00203DGR2_pProtein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds
YMR109W2.870.00203MYO5One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization

GO enrichment analysis for SGTC_186
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1919.15E-50SGTC_100279-0212 42.6 μMChemDiv (Drug-like library)398510.0576923TRP & mitochondrial translation
0.1719.73E-40SGTC_6023130-1533 38.1 μMChemDiv (Drug-like library)7209410.155172
0.1626.70E-36SGTC_190279-0214 38.4 μMChemDiv (Drug-like library)35662740.0576923TRP & mitochondrial translation
0.1554.98E-33SGTC_1742st038235 28.9 μMTimTec (Natural product derivative library)5641030.130435mitochondrial stress
0.1483.01E-30SGTC_1923455-0609 60.9 μMChemDiv (Drug-like library)37696390.0576923
0.1423.56E-28SGTC_14780453-0656 35.7 μMChemDiv (Drug-like library)52584960.0806452
0.1361.49E-25SGTC_2113455-0679 143.5 μMChemDiv (Drug-like library)7486490.157895
0.1352.10E-25SGTC_7450469-0705 296.0 μMChemDiv (Drug-like library)34867360.0793651mitochondrial processes
0.1314.81E-24SGTC_1954234-0266 16.7 μMChemDiv (Drug-like library)23033540.0862069
0.1315.87E-24SGTC_5203584-0023 682.0 μMChemDiv (Drug-like library)13407900.0625
0.1284.24E-23SGTC_2516gossypol 71.5 μMTimTec (Pure natural product library)35030.125
0.1241.52E-21SGTC_1731273-0061 2.7 μMChemDiv (Drug-like library)28474140.0847458mitochondrial stress
0.1232.56E-21SGTC_2513baicalein 25.6 μMMicrosource (Natural product library)52816050.125calcium & mitochondrial duress
0.1225.87E-21SGTC_5961155-0152 116.0 μMChemDiv (Drug-like library)2803130.115385TRP & mitochondrial translation
0.1181.38E-19SGTC_2231micatex 6.9 μMMiscellaneous207370.166667

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_470149-013524.25 μM0.3181825239155ChemDiv (Drug-like library)328.445225.87933TSC3-RPN4
SGTC_10553448-067286 μM0.306122748378ChemDiv (Drug-like library)302.369723.92412
SGTC_23217390090138.78 μM0.28649046Chembridge (Fragment library)214.263062.85423
SGTC_6641222-005414.9 μM0.2777786813991ChemDiv (Drug-like library)287.3717833.72413sphingolipid biosynthesis & PDR1
SGTC_23679070478135.38 μM0.26572802Chembridge (Fragment library)214.263062.85423cell wall
SGTC_3273913785949.47 μM0.262377234Chembridge (Drug-like library)266.360764.53803
SGTC_14554262-0120131 μM0.2558141529587ChemDiv (Drug-like library)308.460424.87302plasma membrane duress
SGTC_20975376186200 μM0.255319742755Chembridge (Fragment library)198.263662.55712
SGTC_1935st07453241.6 μM0.2549022829742TimTec (Natural product derivative library)272.295843.55724
SGTC_950471-0001561.06 μM0.254015405ChemDiv (Drug-like library)356.455325.75134