Deletion Strain | FD score | P-value | Gene | Gene Description |
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YPL229W_p | 5.06 | 2.12E-7 | YPL229W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication |
YJL062W | 4.94 | 3.89E-7 | LAS21 | Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity |
YDL240W | 4.70 | 1.32E-6 | LRG1 | Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis |
YPL225W | 4.52 | 3.15E-6 | YPL225W | Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress |
YJR105W | 4.44 | 4.45E-6 | ADO1 | Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle |
YLR287C-A | 4.33 | 7.53E-6 | RPS30A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication |
YPL101W | 4.17 | 1.53E-5 | ELP4 | Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity |
YDR363W-A | 4.16 | 1.59E-5 | SEM1 | Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress |
YNL100W | 3.99 | 3.25E-5 | AIM37 | Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture |
YGL041C_d | 3.99 | 3.28E-5 | YGL041C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YKL118W_d | 3.99 | 3.36E-5 | YKL118W_d | Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 |
YGR183C | 3.97 | 3.54E-5 | QCR9 | Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex |
YIL009W | 3.91 | 4.67E-5 | FAA3 | Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
YBR238C | 3.87 | 5.50E-5 | YBR238C | Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span |
YBR069C | 3.83 | 6.35E-5 | TAT1 | Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress |