st057641

2-(4-hydroxyphenyl)-3-methoxy-2,3-dihydrochromen-4-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1863
Screen concentration 20.1 μM
Source TimTec (Natural product derivative library)
PubChem CID 3921635
SMILES COC1C(OC2=CC=CC=C2C1=O)C3=CC=C(C=C3)O
Standardized SMILES COC1C(Oc2ccccc2C1=O)c3ccc(O)cc3
Molecular weight 270.28
ALogP 2.61
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.86
% growth inhibition (Hom. pool) 4.81


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3921635
Download HIP data (tab-delimited text)  (excel)
Gene:ASA1(YPR085C)|FD-Score:3.29|P-value:4.99E-4|Clearance:0.06||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 Gene:CCT4(YDL143W)|FD-Score:3.6|P-value:1.59E-4|Clearance:0.05||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CDC28(YBR160W)|FD-Score:-6.57|P-value:2.60E-11|Clearance:0||SGD DESC:Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress Gene:GCD2(YGR083C)|FD-Score:4.17|P-value:1.55E-5|Clearance:0.25||SGD DESC:Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Gene:GPI13(YLL031C)|FD-Score:3.23|P-value:6.10E-4|Clearance:0.09||SGD DESC:ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein Gene:HRT1(YOL133W)|FD-Score:3.14|P-value:8.35E-4|Clearance:0.05||SGD DESC:RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF Gene:NIP1(YMR309C)|FD-Score:3.92|P-value:4.48E-5|Clearance:0.32||SGD DESC:eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection Gene:RBA50(YDR527W)|FD-Score:3.32|P-value:4.44E-4|Clearance:0.03||SGD DESC:Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 Gene:RET1(YOR207C)|FD-Score:3.55|P-value:1.92E-4|Clearance:0.23||SGD DESC:Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs Gene:RIB2(YOL066C)|FD-Score:-3.57|P-value:1.82E-4|Clearance:0||SGD DESC:Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs Gene:VTI1(YMR197C)|FD-Score:5.04|P-value:2.28E-7|Clearance:0.47||SGD DESC:Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways Gene:YJL009W(YJL009W_d)|FD-Score:4.63|P-value:1.80E-6|Clearance:0.47||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex Gene:YOR218C(YOR218C_d)|FD-Score:-3.59|P-value:1.68E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W Gene:ASA1(YPR085C)|FD-Score:3.29|P-value:4.99E-4|Clearance:0.06||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 Gene:CCT4(YDL143W)|FD-Score:3.6|P-value:1.59E-4|Clearance:0.05||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CDC28(YBR160W)|FD-Score:-6.57|P-value:2.60E-11|Clearance:0||SGD DESC:Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress Gene:GCD2(YGR083C)|FD-Score:4.17|P-value:1.55E-5|Clearance:0.25||SGD DESC:Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Gene:GPI13(YLL031C)|FD-Score:3.23|P-value:6.10E-4|Clearance:0.09||SGD DESC:ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein Gene:HRT1(YOL133W)|FD-Score:3.14|P-value:8.35E-4|Clearance:0.05||SGD DESC:RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF Gene:NIP1(YMR309C)|FD-Score:3.92|P-value:4.48E-5|Clearance:0.32||SGD DESC:eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection Gene:RBA50(YDR527W)|FD-Score:3.32|P-value:4.44E-4|Clearance:0.03||SGD DESC:Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 Gene:RET1(YOR207C)|FD-Score:3.55|P-value:1.92E-4|Clearance:0.23||SGD DESC:Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs Gene:RIB2(YOL066C)|FD-Score:-3.57|P-value:1.82E-4|Clearance:0||SGD DESC:Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs Gene:VTI1(YMR197C)|FD-Score:5.04|P-value:2.28E-7|Clearance:0.47||SGD DESC:Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways Gene:YJL009W(YJL009W_d)|FD-Score:4.63|P-value:1.80E-6|Clearance:0.47||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex Gene:YOR218C(YOR218C_d)|FD-Score:-3.59|P-value:1.68E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3921635
Download HOP data (tab-delimited text)  (excel)
Gene:AIM32(YML050W)|FD-Score:3.22|P-value:6.33E-4||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:ARP1(YHR129C)|FD-Score:4.37|P-value:6.30E-6||SGD DESC:Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin Gene:BCK1(YJL095W)|FD-Score:-3.48|P-value:2.49E-4||SGD DESC:Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p Gene:BRE1(YDL074C)|FD-Score:3.32|P-value:4.48E-4||SGD DESC:E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control Gene:CCW12(YLR110C)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication Gene:CDH1(YGL003C)|FD-Score:-3.31|P-value:4.71E-4||SGD DESC:Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p Gene:CMR1(YDL156W)|FD-Score:3.85|P-value:5.84E-5||SGD DESC:DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS Gene:EMC6(YLL014W)|FD-Score:3.97|P-value:3.60E-5||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 Gene:EMI2(YDR516C)|FD-Score:4.66|P-value:1.56E-6||SGD DESC:Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:FKS1(YLR342W)|FD-Score:5.75|P-value:4.39E-9||SGD DESC:Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling Gene:FMP27(YLR454W_p)|FD-Score:3.8|P-value:7.12E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FUI1(YBL042C)|FD-Score:3.39|P-value:3.46E-4||SGD DESC:High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress Gene:FYV1(YDR024W_d)|FD-Score:4.14|P-value:1.76E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin Gene:GCS1(YDL226C)|FD-Score:3.18|P-value:7.25E-4||SGD DESC:ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p Gene:GYP1(YOR070C)|FD-Score:3.25|P-value:5.79E-4||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HIS6(YIL020C)|FD-Score:3.21|P-value:6.71E-4||SGD DESC:Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts Gene:HOP1(YIL072W)|FD-Score:3.3|P-value:4.77E-4||SGD DESC:Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments Gene:HYR1(YIR037W)|FD-Score:3.43|P-value:3.05E-4||SGD DESC:Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor Gene:IAH1(YOR126C)|FD-Score:-3.28|P-value:5.18E-4||SGD DESC:Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing Gene:INM1(YHR046C)|FD-Score:3.13|P-value:8.71E-4||SGD DESC:Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate Gene:MCT1(YOR221C)|FD-Score:3.39|P-value:3.49E-4||SGD DESC:Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling Gene:MDM35(YKL053C-A)|FD-Score:3.14|P-value:8.56E-4||SGD DESC:Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress Gene:MMS22(YLR320W)|FD-Score:3.61|P-value:1.54E-4||SGD DESC:Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation Gene:MRPS9(YBR146W)|FD-Score:3.4|P-value:3.31E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MTC6(YHR151C)|FD-Score:3.97|P-value:3.54E-5||SGD DESC:Protein of unknown function; mtc6 is synthetically sick with cdc13-1 Gene:NMD4(YLR363C)|FD-Score:3.4|P-value:3.38E-4||SGD DESC:Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:OPT1(YJL212C)|FD-Score:3.13|P-value:8.67E-4||SGD DESC:Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family Gene:PDR1(YGL013C)|FD-Score:3.16|P-value:7.97E-4||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PET123(YOR158W)|FD-Score:4.25|P-value:1.08E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator Gene:POM33(YLL023C)|FD-Score:-3.18|P-value:7.34E-4||SGD DESC:Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress Gene:PTC7(YHR076W)|FD-Score:4.26|P-value:1.03E-5||SGD DESC:Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope Gene:RPN4(YDL020C)|FD-Score:6.36|P-value:9.95E-11||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RTC4(YNL254C)|FD-Score:-3.16|P-value:8.01E-4||SGD DESC:Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:SAC1(YKL212W)|FD-Score:4.66|P-value:1.61E-6||SGD DESC:Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism Gene:SAE2(YGL175C)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents Gene:SDH1(YKL148C)|FD-Score:3.28|P-value:5.24E-4||SGD DESC:Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits Gene:SDH4(YDR178W)|FD-Score:4.44|P-value:4.58E-6||SGD DESC:Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain Gene:SER33(YIL074C)|FD-Score:3.59|P-value:1.64E-4||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication Gene:SOL2(YCR073W-A)|FD-Score:3.25|P-value:5.78E-4||SGD DESC:Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication Gene:SSP120(YLR250W)|FD-Score:-3.25|P-value:5.81E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:VPH2(YKL119C)|FD-Score:-3.74|P-value:9.32E-5||SGD DESC:Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) Gene:YAP5(YIR018W)|FD-Score:3.1|P-value:9.70E-4||SGD DESC:Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication Gene:YBL039W-B(YBL039W-B_p)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Putative protein of unknown function Gene:YBR137W(YBR137W)|FD-Score:-3.11|P-value:9.41E-4||SGD DESC:Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene Gene:YBR184W(YBR184W_p)|FD-Score:-3.36|P-value:3.93E-4||SGD DESC:Putative protein of unknown function; YBR184W is not an essential gene Gene:YDR061W(YDR061W_p)|FD-Score:3.96|P-value:3.70E-5||SGD DESC:Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance Gene:YEL028W(YEL028W_d)|FD-Score:3.67|P-value:1.22E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YER046W-A(YER046W-A_d)|FD-Score:3.38|P-value:3.68E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHM2(YMR241W)|FD-Score:4.19|P-value:1.37E-5||SGD DESC:Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome Gene:YIL067C(YIL067C_p)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:Uncharacterized protein of unknown function Gene:YKL118W(YKL118W_d)|FD-Score:3.65|P-value:1.34E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Gene:YLR287C(YLR287C_p)|FD-Score:-5.08|P-value:1.89E-7||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene Gene:YLR428C(YLR428C_d)|FD-Score:5.8|P-value:3.39E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Gene:YMR194C-A(YMR194C-A_d)|FD-Score:-3.85|P-value:5.85E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR244W(YMR244W_p)|FD-Score:3.73|P-value:9.67E-5||SGD DESC:Putative protein of unknown function Gene:YNL228W(YNL228W_d)|FD-Score:3.59|P-value:1.63E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Gene:YOR228C(YOR228C)|FD-Score:3.17|P-value:7.60E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YPL035C(YPL035C_d)|FD-Score:3.4|P-value:3.37E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene Gene:ZEO1(YOL109W)|FD-Score:3.46|P-value:2.70E-4||SGD DESC:Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria Gene:AIM32(YML050W)|FD-Score:3.22|P-value:6.33E-4||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:ARP1(YHR129C)|FD-Score:4.37|P-value:6.30E-6||SGD DESC:Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin Gene:BCK1(YJL095W)|FD-Score:-3.48|P-value:2.49E-4||SGD DESC:Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p Gene:BRE1(YDL074C)|FD-Score:3.32|P-value:4.48E-4||SGD DESC:E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control Gene:CCW12(YLR110C)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication Gene:CDH1(YGL003C)|FD-Score:-3.31|P-value:4.71E-4||SGD DESC:Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p Gene:CMR1(YDL156W)|FD-Score:3.85|P-value:5.84E-5||SGD DESC:DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS Gene:EMC6(YLL014W)|FD-Score:3.97|P-value:3.60E-5||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 Gene:EMI2(YDR516C)|FD-Score:4.66|P-value:1.56E-6||SGD DESC:Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:FKS1(YLR342W)|FD-Score:5.75|P-value:4.39E-9||SGD DESC:Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling Gene:FMP27(YLR454W_p)|FD-Score:3.8|P-value:7.12E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FUI1(YBL042C)|FD-Score:3.39|P-value:3.46E-4||SGD DESC:High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress Gene:FYV1(YDR024W_d)|FD-Score:4.14|P-value:1.76E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin Gene:GCS1(YDL226C)|FD-Score:3.18|P-value:7.25E-4||SGD DESC:ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p Gene:GYP1(YOR070C)|FD-Score:3.25|P-value:5.79E-4||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HIS6(YIL020C)|FD-Score:3.21|P-value:6.71E-4||SGD DESC:Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts Gene:HOP1(YIL072W)|FD-Score:3.3|P-value:4.77E-4||SGD DESC:Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments Gene:HYR1(YIR037W)|FD-Score:3.43|P-value:3.05E-4||SGD DESC:Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor Gene:IAH1(YOR126C)|FD-Score:-3.28|P-value:5.18E-4||SGD DESC:Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing Gene:INM1(YHR046C)|FD-Score:3.13|P-value:8.71E-4||SGD DESC:Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate Gene:MCT1(YOR221C)|FD-Score:3.39|P-value:3.49E-4||SGD DESC:Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling Gene:MDM35(YKL053C-A)|FD-Score:3.14|P-value:8.56E-4||SGD DESC:Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress Gene:MMS22(YLR320W)|FD-Score:3.61|P-value:1.54E-4||SGD DESC:Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation Gene:MRPS9(YBR146W)|FD-Score:3.4|P-value:3.31E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MTC6(YHR151C)|FD-Score:3.97|P-value:3.54E-5||SGD DESC:Protein of unknown function; mtc6 is synthetically sick with cdc13-1 Gene:NMD4(YLR363C)|FD-Score:3.4|P-value:3.38E-4||SGD DESC:Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:OPT1(YJL212C)|FD-Score:3.13|P-value:8.67E-4||SGD DESC:Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family Gene:PDR1(YGL013C)|FD-Score:3.16|P-value:7.97E-4||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PET123(YOR158W)|FD-Score:4.25|P-value:1.08E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator Gene:POM33(YLL023C)|FD-Score:-3.18|P-value:7.34E-4||SGD DESC:Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress Gene:PTC7(YHR076W)|FD-Score:4.26|P-value:1.03E-5||SGD DESC:Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope Gene:RPN4(YDL020C)|FD-Score:6.36|P-value:9.95E-11||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RTC4(YNL254C)|FD-Score:-3.16|P-value:8.01E-4||SGD DESC:Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:SAC1(YKL212W)|FD-Score:4.66|P-value:1.61E-6||SGD DESC:Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism Gene:SAE2(YGL175C)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents Gene:SDH1(YKL148C)|FD-Score:3.28|P-value:5.24E-4||SGD DESC:Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits Gene:SDH4(YDR178W)|FD-Score:4.44|P-value:4.58E-6||SGD DESC:Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain Gene:SER33(YIL074C)|FD-Score:3.59|P-value:1.64E-4||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication Gene:SOL2(YCR073W-A)|FD-Score:3.25|P-value:5.78E-4||SGD DESC:Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication Gene:SSP120(YLR250W)|FD-Score:-3.25|P-value:5.81E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:VPH2(YKL119C)|FD-Score:-3.74|P-value:9.32E-5||SGD DESC:Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) Gene:YAP5(YIR018W)|FD-Score:3.1|P-value:9.70E-4||SGD DESC:Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication Gene:YBL039W-B(YBL039W-B_p)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Putative protein of unknown function Gene:YBR137W(YBR137W)|FD-Score:-3.11|P-value:9.41E-4||SGD DESC:Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene Gene:YBR184W(YBR184W_p)|FD-Score:-3.36|P-value:3.93E-4||SGD DESC:Putative protein of unknown function; YBR184W is not an essential gene Gene:YDR061W(YDR061W_p)|FD-Score:3.96|P-value:3.70E-5||SGD DESC:Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance Gene:YEL028W(YEL028W_d)|FD-Score:3.67|P-value:1.22E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YER046W-A(YER046W-A_d)|FD-Score:3.38|P-value:3.68E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHM2(YMR241W)|FD-Score:4.19|P-value:1.37E-5||SGD DESC:Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome Gene:YIL067C(YIL067C_p)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:Uncharacterized protein of unknown function Gene:YKL118W(YKL118W_d)|FD-Score:3.65|P-value:1.34E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Gene:YLR287C(YLR287C_p)|FD-Score:-5.08|P-value:1.89E-7||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene Gene:YLR428C(YLR428C_d)|FD-Score:5.8|P-value:3.39E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Gene:YMR194C-A(YMR194C-A_d)|FD-Score:-3.85|P-value:5.85E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR244W(YMR244W_p)|FD-Score:3.73|P-value:9.67E-5||SGD DESC:Putative protein of unknown function Gene:YNL228W(YNL228W_d)|FD-Score:3.59|P-value:1.63E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Gene:YOR228C(YOR228C)|FD-Score:3.17|P-value:7.60E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YPL035C(YPL035C_d)|FD-Score:3.4|P-value:3.37E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene Gene:ZEO1(YOL109W)|FD-Score:3.46|P-value:2.70E-4||SGD DESC:Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YMR197C5.042.28E-70.47VTI1Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways
YJL009W_d4.631.80E-60.47YJL009W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
YGR083C4.171.55E-50.25GCD2Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YMR309C3.924.48E-50.32NIP1eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection
YDL143W3.601.59E-40.05CCT4Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YOR207C3.551.92E-40.23RET1Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
YDR527W3.324.44E-40.03RBA50Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
YPR085C3.294.99E-40.06ASA1Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
YLL031C3.236.10E-40.09GPI13ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein
YOL133W3.148.35E-40.05HRT1RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF
YGL069C_d3.090.001010.07YGL069C_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance
YKL004W3.020.001280.04AUR1Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
YLR378C2.970.001470.03SEC61Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
YNL207W2.950.001610.01RIO2Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
YBR002C2.940.001640.02RER2Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDL020C6.369.95E-11RPN4Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
YLR428C_d5.803.39E-9YLR428C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1
YLR342W5.754.39E-9FKS1Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
YDR516C4.661.56E-6EMI2Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
YKL212W4.661.61E-6SAC1Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism
YDR178W4.444.58E-6SDH4Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
YHR129C4.376.30E-6ARP1Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin
YHR076W4.261.03E-5PTC7Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope
YOR158W4.251.08E-5PET123Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
YMR241W4.191.37E-5YHM2Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome
YDR024W_d4.141.76E-5FYV1_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin
YHR151C3.973.54E-5MTC6Protein of unknown function; mtc6 is synthetically sick with cdc13-1
YLL014W3.973.60E-5EMC6Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93
YDR061W_p3.963.70E-5YDR061W_pProtein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
YDL156W3.855.84E-5CMR1DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS

GO enrichment analysis for SGTC_1863
No biological processes are significantly enriched (FDR < 0.1).

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1454.57E-29SGTC_26602',4'-dihydroxychalcone 17.1 μMTimTec (Pure natural product library)53572180.203704
0.1397.99E-27SGTC_21515563267 85.4 μMChembridge (Fragment library)53108240.118644
0.1186.57E-20SGTC_26682',4'-dihydroxychalcone 15.1 μMTimTec (Pure natural product library)53572180.203704
0.1089.63E-17SGTC_2508celastrol 40.5 μMMicrosource (Natural product library)1227240.097561PDR1
0.1056.78E-16SGTC_1773st048542 73.6 μMTimTec (Natural product derivative library)32371380.125
0.1048.97E-16SGTC_25792',5'-dihydroxy-4-methoxychalcone 13.2 μMMicrosource (Natural product library)53558880.180328
0.1032.71E-15SGTC_1470k295-0292 231.0 μMChemDiv (Drug-like library)50456120.121622
0.1001.69E-14SGTC_1643st009866 20.2 μMTimTec (Natural product derivative library)31562730.202899
0.0976.95E-14SGTC_15852',4'-dihydroxychalcone 10.4 μMTimTec (Pure natural product library)53572180.203704
0.0936.66E-13SGTC_32799140807 49.5 μMChembridge (Drug-like library)455957180.0666667
0.0921.11E-12SGTC_12430416-0003 5.7 μMChemDiv (Drug-like library)21419770.150943PDR1
0.0912.11E-12SGTC_2695st077686 52.0 μMTimTec (Natural product derivative library)28760920.0705882
0.0912.36E-12SGTC_274sirtinol 40.1 μMMiscellaneous68364420.136986
0.0871.95E-11SGTC_1123mangostin 811.3 nMTimTec (Natural product library)52816500.161765mitochondrial response to ROS
0.0872.76E-11SGTC_1069diphenylcyclopropenone 8.5 μMNIH Clinical Collection650570.159091

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_16014'-hydroxyflavanone55.5 μM0.478261165506TimTec (Pure natural product library)240.253982.85713RPP1 & pyrimidine depletion
SGTC_1970st07012235.8 μM0.392157102928TimTec (Natural product derivative library)254.280563.08303TSC3-RPN4
SGTC_1923st05845819.1 μM0.3653853534982TimTec (Natural product derivative library)240.253982.85713
SGTC_1889st0590805.18 μM0.333333176925TimTec (Natural product derivative library)240.253982.85713
SGTC_15494'-methoxyflavonol74.6 μM0.31481597141TimTec (Pure natural product library)268.264082.58214
SGTC_15372',6'-dihydroxyflavanone78 μM0.3090915106787TimTec (Pure natural product library)256.253382.61524
SGTC_11103-hydroxy-3'-methoxyflavone1.24 μM0.298246676296TimTec (Natural product library)268.264082.58214iron homeostasis
SGTC_26222-methoxyxanthone59.94 μM0.29411871034Microsource (Natural product library)226.22742.94803
SGTC_1745st08149574 μM0.29310313842402TimTec (Natural product derivative library)270.279962.94814RNA processing & uracil transport
SGTC_1848st05600316.4 μM0.288462146492TimTec (Natural product derivative library)252.264683.1203