| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YBR084C-A | 7.31 | 1.34E-13 | RPL19A | Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication |
| YJL105W | 6.30 | 1.53E-10 | SET4 | Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication |
| YFR035C_p | 5.81 | 3.21E-9 | YFR035C_p | Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein |
| YDL185W | 5.73 | 5.06E-9 | VMA1 | Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease |
| YLL014W | 5.49 | 2.06E-8 | EMC6 | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 |
| YLR027C | 5.46 | 2.42E-8 | AAT2 | Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells |
| YGL117W_p | 5.10 | 1.68E-7 | YGL117W_p | Putative protein of unknown function |
| YHR136C | 5.06 | 2.15E-7 | SPL2 | Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm |
| YKR021W | 4.77 | 9.01E-7 | ALY1 | Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication |
| YFL010W-A | 4.76 | 9.84E-7 | AUA1 | Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease |
| YGR290W_d | 4.75 | 1.04E-6 | YGR290W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) |
| YDR354W | 4.62 | 1.94E-6 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
| YNL082W | 4.56 | 2.59E-6 | PMS1 | ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL |
| YPR123C_d | 4.55 | 2.66E-6 | YPR123C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR |
| YER090W | 4.49 | 3.53E-6 | TRP2 | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p |
