Deletion Strain | FD score | P-value | Gene | Gene Description |
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YHR139C-A_d | 8.76 | 1.01E-18 | YHR139C-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YOL068C | 7.96 | 8.72E-16 | HST1 | NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance |
YER129W | 6.42 | 6.87E-11 | SAK1 | Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome |
YML006C | 6.35 | 1.09E-10 | GIS4 | CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway |
YOR069W | 4.87 | 5.45E-7 | VPS5 | Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes |
YPL219W | 4.63 | 1.80E-6 | PCL8 | Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation |
YPL172C | 4.49 | 3.57E-6 | COX10 | Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders |
YGL243W | 4.42 | 4.86E-6 | TAD1 | tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala |
YOR318C_d | 4.39 | 5.55E-6 | YOR318C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo |
YKR093W | 4.30 | 8.66E-6 | PTR2 | Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p |
YIR033W | 4.21 | 1.25E-5 | MGA2 | ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting |
YKL091C | 4.21 | 1.26E-5 | YKL091C | Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study |
YOR343C_d | 4.21 | 1.29E-5 | YOR343C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YJL053W | 4.20 | 1.32E-5 | PEP8 | Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress |
YKL107W_p | 4.18 | 1.43E-5 | YKL107W_p | Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein |