st059080

2-(2-hydroxyphenyl)-2,3-dihydrochromen-4-one

Isolated from Daphnopsis sellowiana.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1889
Screen concentration 5.2 μM
Source TimTec (Natural product derivative library)
PubChem CID 176925
SMILES C1C(OC2=CC=CC=C2C1=O)C3=CC=CC=C3O
Standardized SMILES Oc1ccccc1C2CC(=O)c3ccccc3O2
Molecular weight 240.254
ALogP 2.86
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 11.53
% growth inhibition (Hom. pool) 4.65


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 176925
Download HIP data (tab-delimited text)  (excel)
Gene:BPL1(YDL141W)|FD-Score:3.66|P-value:1.26E-4|Clearance:0.37||SGD DESC:Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation Gene:CUS1(YMR240C)|FD-Score:3.29|P-value:5.01E-4|Clearance:0.12||SGD DESC:Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p Gene:DPS1(YLL018C)|FD-Score:3.86|P-value:5.71E-5|Clearance:0.2||SGD DESC:Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation Gene:HEM4(YOR278W)|FD-Score:-4.09|P-value:2.13E-5|Clearance:0||SGD DESC:Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria Gene:JIP5(YPR169W)|FD-Score:5.1|P-value:1.72E-7|Clearance:0.95||SGD DESC:Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein Gene:LAS17(YOR181W)|FD-Score:3.11|P-value:9.45E-4|Clearance:0.03||SGD DESC:Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP) Gene:MTR3(YGR158C)|FD-Score:5.48|P-value:2.14E-8|Clearance:0.95||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) Gene:NOP56(YLR197W)|FD-Score:-4.46|P-value:4.10E-6|Clearance:0||SGD DESC:Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects Gene:RNA15(YGL044C)|FD-Score:4.02|P-value:2.90E-5|Clearance:0.16||SGD DESC:Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping Gene:RRN5(YLR141W)|FD-Score:4.14|P-value:1.71E-5|Clearance:0.12||SGD DESC:Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p Gene:SPP381(YBR152W)|FD-Score:-4|P-value:3.12E-5|Clearance:0||SGD DESC:mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p Gene:TIM54(YJL054W)|FD-Score:3.17|P-value:7.73E-4|Clearance:0.06||SGD DESC:Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane Gene:BPL1(YDL141W)|FD-Score:3.66|P-value:1.26E-4|Clearance:0.37||SGD DESC:Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation Gene:CUS1(YMR240C)|FD-Score:3.29|P-value:5.01E-4|Clearance:0.12||SGD DESC:Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p Gene:DPS1(YLL018C)|FD-Score:3.86|P-value:5.71E-5|Clearance:0.2||SGD DESC:Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation Gene:HEM4(YOR278W)|FD-Score:-4.09|P-value:2.13E-5|Clearance:0||SGD DESC:Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria Gene:JIP5(YPR169W)|FD-Score:5.1|P-value:1.72E-7|Clearance:0.95||SGD DESC:Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein Gene:LAS17(YOR181W)|FD-Score:3.11|P-value:9.45E-4|Clearance:0.03||SGD DESC:Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP) Gene:MTR3(YGR158C)|FD-Score:5.48|P-value:2.14E-8|Clearance:0.95||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) Gene:NOP56(YLR197W)|FD-Score:-4.46|P-value:4.10E-6|Clearance:0||SGD DESC:Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects Gene:RNA15(YGL044C)|FD-Score:4.02|P-value:2.90E-5|Clearance:0.16||SGD DESC:Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping Gene:RRN5(YLR141W)|FD-Score:4.14|P-value:1.71E-5|Clearance:0.12||SGD DESC:Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p Gene:SPP381(YBR152W)|FD-Score:-4|P-value:3.12E-5|Clearance:0||SGD DESC:mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p Gene:TIM54(YJL054W)|FD-Score:3.17|P-value:7.73E-4|Clearance:0.06||SGD DESC:Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 176925
Download HOP data (tab-delimited text)  (excel)
Gene:ARG2(YJL071W)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p Gene:BNR1(YIL159W)|FD-Score:3.38|P-value:3.65E-4||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 Gene:BRO1(YPL084W)|FD-Score:3.53|P-value:2.10E-4||SGD DESC:Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes Gene:BRR1(YPR057W)|FD-Score:3.65|P-value:1.31E-4||SGD DESC:snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed Gene:CAD1(YDR423C)|FD-Score:5.49|P-value:2.05E-8||SGD DESC:AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication Gene:CAN1(YEL063C)|FD-Score:3.44|P-value:2.92E-4||SGD DESC:Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication Gene:CCC2(YDR270W)|FD-Score:-5.38|P-value:3.74E-8||SGD DESC:Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism Gene:CCR4(YAL021C)|FD-Score:-3.3|P-value:4.86E-4||SGD DESC:Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening Gene:COG6(YNL041C)|FD-Score:-3.81|P-value:6.91E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COX10(YPL172C)|FD-Score:3.15|P-value:8.28E-4||SGD DESC:Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders Gene:COX15(YER141W)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase Gene:DHH1(YDL160C)|FD-Score:-3.67|P-value:1.20E-4||SGD DESC:Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress Gene:DIF1(YLR437C)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein Gene:DIP5(YPL265W)|FD-Score:3.89|P-value:4.99E-5||SGD DESC:Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress Gene:DUF1(YOL087C)|FD-Score:-5|P-value:2.88E-7||SGD DESC:Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid Gene:EAF7(YNL136W)|FD-Score:3.22|P-value:6.40E-4||SGD DESC:Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A Gene:ELO1(YJL196C)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication Gene:FYV6(YNL133C)|FD-Score:-3.13|P-value:8.87E-4||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining Gene:GCG1(YER163C_p)|FD-Score:3.74|P-value:9.23E-5||SGD DESC:Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle Gene:GIT1(YCR098C)|FD-Score:4.69|P-value:1.33E-6||SGD DESC:Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability Gene:GOS1(YHL031C)|FD-Score:-3.42|P-value:3.18E-4||SGD DESC:v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 Gene:HAC1(YFL031W)|FD-Score:-4.15|P-value:1.65E-5||SGD DESC:Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress Gene:HGH1(YGR187C)|FD-Score:3.48|P-value:2.50E-4||SGD DESC:Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress Gene:HST4(YDR191W)|FD-Score:3.84|P-value:6.25E-5||SGD DESC:Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism Gene:IES1(YFL013C)|FD-Score:5.26|P-value:7.39E-8||SGD DESC:Subunit of the INO80 chromatin remodeling complex Gene:INO1(YJL153C)|FD-Score:3.23|P-value:6.15E-4||SGD DESC:Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element Gene:IRC13(YOR235W_d)|FD-Score:-3.49|P-value:2.39E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci Gene:IRS4(YKR019C)|FD-Score:-3.57|P-value:1.80E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:KES1(YPL145C)|FD-Score:3.55|P-value:1.96E-4||SGD DESC:One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication Gene:LHS1(YKL073W)|FD-Score:3.11|P-value:9.37E-4||SGD DESC:Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway Gene:MAC1(YMR021C)|FD-Score:-3.59|P-value:1.65E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MBA1(YBR185C)|FD-Score:3.2|P-value:6.94E-4||SGD DESC:Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane Gene:MDM30(YLR368W)|FD-Score:3.27|P-value:5.38E-4||SGD DESC:F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains Gene:MEC3(YLR288C)|FD-Score:3.39|P-value:3.45E-4||SGD DESC:DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 Gene:MPM1(YJL066C)|FD-Score:-3.28|P-value:5.15E-4||SGD DESC:Mitochondrial intermembrane space protein of unknown function Gene:MRP2(YPR166C)|FD-Score:3.96|P-value:3.81E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:NCE101(YJL205C)|FD-Score:-3.36|P-value:3.94E-4||SGD DESC:Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences Gene:NVJ1(YHR195W)|FD-Score:3.11|P-value:9.37E-4||SGD DESC:Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) Gene:OPI3(YJR073C)|FD-Score:-3.12|P-value:9.08E-4||SGD DESC:Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis Gene:PDR1(YGL013C)|FD-Score:3.78|P-value:7.73E-5||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PHM6(YDR281C)|FD-Score:4.02|P-value:2.94E-5||SGD DESC:Protein of unknown function, expression is regulated by phosphate levels Gene:PMT3(YOR321W)|FD-Score:3.79|P-value:7.56E-5||SGD DESC:Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication Gene:PRM9(YAR031W)|FD-Score:-3.24|P-value:5.88E-4||SGD DESC:Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family Gene:RKR1(YMR247C)|FD-Score:-3.47|P-value:2.59E-4||SGD DESC:RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice Gene:RNH201(YNL072W)|FD-Score:-3.22|P-value:6.36E-4||SGD DESC:Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome Gene:RPS1B(YML063W)|FD-Score:3.2|P-value:6.83E-4||SGD DESC:Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication Gene:RPS7A(YOR096W)|FD-Score:3.88|P-value:5.19E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication Gene:RPS8A(YBL072C)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication Gene:RPS9A(YPL081W)|FD-Score:-3.43|P-value:3.07E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication Gene:SAC3(YDR159W)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP) Gene:SCW10(YMR305C)|FD-Score:3.96|P-value:3.76E-5||SGD DESC:Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p Gene:SEC66(YBR171W)|FD-Score:4.95|P-value:3.74E-7||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SLZ1(YNL196C_p)|FD-Score:4.72|P-value:1.17E-6||SGD DESC:Sporulation-specific protein with a leucine zipper motif Gene:SNT1(YCR033W)|FD-Score:-3.11|P-value:9.43E-4||SGD DESC:Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance Gene:SPI1(YER150W)|FD-Score:-3.16|P-value:7.76E-4||SGD DESC:GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p Gene:SPO12(YHR152W)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis Gene:SSN3(YPL042C)|FD-Score:-3.4|P-value:3.39E-4||SGD DESC:Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression Gene:UBC13(YDR092W)|FD-Score:4.81|P-value:7.37E-7||SGD DESC:Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus Gene:UFD4(YKL010C)|FD-Score:3.21|P-value:6.62E-4||SGD DESC:Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress Gene:UPS3(YDR185C)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations Gene:VAB2(YEL005C)|FD-Score:-3.26|P-value:5.66E-4||SGD DESC:Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter Gene:VAM3(YOR106W)|FD-Score:-3.39|P-value:3.44E-4||SGD DESC:Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region Gene:WSC3(YOL105C)|FD-Score:4.65|P-value:1.62E-6||SGD DESC:Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis Gene:YAT2(YER024W)|FD-Score:3.54|P-value:1.97E-4||SGD DESC:Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane Gene:YBP1(YBR216C)|FD-Score:3.25|P-value:5.81E-4||SGD DESC:Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication Gene:YBR182C-A(YBR182C-A_p)|FD-Score:3.83|P-value:6.51E-5||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YCL074W(YCL074W)|FD-Score:3.94|P-value:4.06E-5||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YER034W(YER034W_p)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress Gene:YER084W(YER084W_p)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YFL042C(YFL042C_p)|FD-Score:3.86|P-value:5.69E-5||SGD DESC:Putative protein of unknown function; YFL042C is not an essential gene Gene:YGR025W(YGR025W_d)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLL044W(YLL044W_d)|FD-Score:3.54|P-value:2.01E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant Gene:YLR294C(YLR294C_d)|FD-Score:4.52|P-value:3.13E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14 Gene:YML122C(YML122C_d)|FD-Score:-3.83|P-value:6.36E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR265C(YMR265C_p)|FD-Score:5.09|P-value:1.79E-7||SGD DESC:Putative protein of unknown function Gene:YNL203C(YNL203C_d)|FD-Score:-3.65|P-value:1.33E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR111W(YOR111W_p)|FD-Score:5.42|P-value:2.91E-8||SGD DESC:Putative protein of unknown function Gene:YPL035C(YPL035C_d)|FD-Score:-3.37|P-value:3.69E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene Gene:YPL080C(YPL080C_d)|FD-Score:-3.41|P-value:3.23E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPR153W(YPR153W)|FD-Score:4.32|P-value:7.73E-6||SGD DESC:Putative protein of unknown function Gene:ZIP2(YGL249W)|FD-Score:3.38|P-value:3.67E-4||SGD DESC:Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress Gene:ZTA1(YBR046C)|FD-Score:4.62|P-value:1.92E-6||SGD DESC:NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin Gene:ARG2(YJL071W)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p Gene:BNR1(YIL159W)|FD-Score:3.38|P-value:3.65E-4||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 Gene:BRO1(YPL084W)|FD-Score:3.53|P-value:2.10E-4||SGD DESC:Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes Gene:BRR1(YPR057W)|FD-Score:3.65|P-value:1.31E-4||SGD DESC:snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed Gene:CAD1(YDR423C)|FD-Score:5.49|P-value:2.05E-8||SGD DESC:AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication Gene:CAN1(YEL063C)|FD-Score:3.44|P-value:2.92E-4||SGD DESC:Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication Gene:CCC2(YDR270W)|FD-Score:-5.38|P-value:3.74E-8||SGD DESC:Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism Gene:CCR4(YAL021C)|FD-Score:-3.3|P-value:4.86E-4||SGD DESC:Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening Gene:COG6(YNL041C)|FD-Score:-3.81|P-value:6.91E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COX10(YPL172C)|FD-Score:3.15|P-value:8.28E-4||SGD DESC:Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders Gene:COX15(YER141W)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase Gene:DHH1(YDL160C)|FD-Score:-3.67|P-value:1.20E-4||SGD DESC:Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress Gene:DIF1(YLR437C)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein Gene:DIP5(YPL265W)|FD-Score:3.89|P-value:4.99E-5||SGD DESC:Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress Gene:DUF1(YOL087C)|FD-Score:-5|P-value:2.88E-7||SGD DESC:Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid Gene:EAF7(YNL136W)|FD-Score:3.22|P-value:6.40E-4||SGD DESC:Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A Gene:ELO1(YJL196C)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication Gene:FYV6(YNL133C)|FD-Score:-3.13|P-value:8.87E-4||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining Gene:GCG1(YER163C_p)|FD-Score:3.74|P-value:9.23E-5||SGD DESC:Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle Gene:GIT1(YCR098C)|FD-Score:4.69|P-value:1.33E-6||SGD DESC:Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability Gene:GOS1(YHL031C)|FD-Score:-3.42|P-value:3.18E-4||SGD DESC:v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 Gene:HAC1(YFL031W)|FD-Score:-4.15|P-value:1.65E-5||SGD DESC:Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress Gene:HGH1(YGR187C)|FD-Score:3.48|P-value:2.50E-4||SGD DESC:Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress Gene:HST4(YDR191W)|FD-Score:3.84|P-value:6.25E-5||SGD DESC:Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism Gene:IES1(YFL013C)|FD-Score:5.26|P-value:7.39E-8||SGD DESC:Subunit of the INO80 chromatin remodeling complex Gene:INO1(YJL153C)|FD-Score:3.23|P-value:6.15E-4||SGD DESC:Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element Gene:IRC13(YOR235W_d)|FD-Score:-3.49|P-value:2.39E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci Gene:IRS4(YKR019C)|FD-Score:-3.57|P-value:1.80E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:KES1(YPL145C)|FD-Score:3.55|P-value:1.96E-4||SGD DESC:One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication Gene:LHS1(YKL073W)|FD-Score:3.11|P-value:9.37E-4||SGD DESC:Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway Gene:MAC1(YMR021C)|FD-Score:-3.59|P-value:1.65E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MBA1(YBR185C)|FD-Score:3.2|P-value:6.94E-4||SGD DESC:Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane Gene:MDM30(YLR368W)|FD-Score:3.27|P-value:5.38E-4||SGD DESC:F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains Gene:MEC3(YLR288C)|FD-Score:3.39|P-value:3.45E-4||SGD DESC:DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 Gene:MPM1(YJL066C)|FD-Score:-3.28|P-value:5.15E-4||SGD DESC:Mitochondrial intermembrane space protein of unknown function Gene:MRP2(YPR166C)|FD-Score:3.96|P-value:3.81E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:NCE101(YJL205C)|FD-Score:-3.36|P-value:3.94E-4||SGD DESC:Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences Gene:NVJ1(YHR195W)|FD-Score:3.11|P-value:9.37E-4||SGD DESC:Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) Gene:OPI3(YJR073C)|FD-Score:-3.12|P-value:9.08E-4||SGD DESC:Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis Gene:PDR1(YGL013C)|FD-Score:3.78|P-value:7.73E-5||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PHM6(YDR281C)|FD-Score:4.02|P-value:2.94E-5||SGD DESC:Protein of unknown function, expression is regulated by phosphate levels Gene:PMT3(YOR321W)|FD-Score:3.79|P-value:7.56E-5||SGD DESC:Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication Gene:PRM9(YAR031W)|FD-Score:-3.24|P-value:5.88E-4||SGD DESC:Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family Gene:RKR1(YMR247C)|FD-Score:-3.47|P-value:2.59E-4||SGD DESC:RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice Gene:RNH201(YNL072W)|FD-Score:-3.22|P-value:6.36E-4||SGD DESC:Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome Gene:RPS1B(YML063W)|FD-Score:3.2|P-value:6.83E-4||SGD DESC:Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication Gene:RPS7A(YOR096W)|FD-Score:3.88|P-value:5.19E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication Gene:RPS8A(YBL072C)|FD-Score:3.39|P-value:3.44E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication Gene:RPS9A(YPL081W)|FD-Score:-3.43|P-value:3.07E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication Gene:SAC3(YDR159W)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP) Gene:SCW10(YMR305C)|FD-Score:3.96|P-value:3.76E-5||SGD DESC:Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p Gene:SEC66(YBR171W)|FD-Score:4.95|P-value:3.74E-7||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SLZ1(YNL196C_p)|FD-Score:4.72|P-value:1.17E-6||SGD DESC:Sporulation-specific protein with a leucine zipper motif Gene:SNT1(YCR033W)|FD-Score:-3.11|P-value:9.43E-4||SGD DESC:Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance Gene:SPI1(YER150W)|FD-Score:-3.16|P-value:7.76E-4||SGD DESC:GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p Gene:SPO12(YHR152W)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis Gene:SSN3(YPL042C)|FD-Score:-3.4|P-value:3.39E-4||SGD DESC:Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression Gene:UBC13(YDR092W)|FD-Score:4.81|P-value:7.37E-7||SGD DESC:Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus Gene:UFD4(YKL010C)|FD-Score:3.21|P-value:6.62E-4||SGD DESC:Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress Gene:UPS3(YDR185C)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations Gene:VAB2(YEL005C)|FD-Score:-3.26|P-value:5.66E-4||SGD DESC:Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter Gene:VAM3(YOR106W)|FD-Score:-3.39|P-value:3.44E-4||SGD DESC:Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region Gene:WSC3(YOL105C)|FD-Score:4.65|P-value:1.62E-6||SGD DESC:Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis Gene:YAT2(YER024W)|FD-Score:3.54|P-value:1.97E-4||SGD DESC:Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane Gene:YBP1(YBR216C)|FD-Score:3.25|P-value:5.81E-4||SGD DESC:Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication Gene:YBR182C-A(YBR182C-A_p)|FD-Score:3.83|P-value:6.51E-5||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YCL074W(YCL074W)|FD-Score:3.94|P-value:4.06E-5||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YER034W(YER034W_p)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress Gene:YER084W(YER084W_p)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YFL042C(YFL042C_p)|FD-Score:3.86|P-value:5.69E-5||SGD DESC:Putative protein of unknown function; YFL042C is not an essential gene Gene:YGR025W(YGR025W_d)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLL044W(YLL044W_d)|FD-Score:3.54|P-value:2.01E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant Gene:YLR294C(YLR294C_d)|FD-Score:4.52|P-value:3.13E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14 Gene:YML122C(YML122C_d)|FD-Score:-3.83|P-value:6.36E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR265C(YMR265C_p)|FD-Score:5.09|P-value:1.79E-7||SGD DESC:Putative protein of unknown function Gene:YNL203C(YNL203C_d)|FD-Score:-3.65|P-value:1.33E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR111W(YOR111W_p)|FD-Score:5.42|P-value:2.91E-8||SGD DESC:Putative protein of unknown function Gene:YPL035C(YPL035C_d)|FD-Score:-3.37|P-value:3.69E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene Gene:YPL080C(YPL080C_d)|FD-Score:-3.41|P-value:3.23E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPR153W(YPR153W)|FD-Score:4.32|P-value:7.73E-6||SGD DESC:Putative protein of unknown function Gene:ZIP2(YGL249W)|FD-Score:3.38|P-value:3.67E-4||SGD DESC:Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress Gene:ZTA1(YBR046C)|FD-Score:4.62|P-value:1.92E-6||SGD DESC:NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGR158C5.482.14E-80.95MTR3Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
YPR169W5.101.72E-70.95JIP5Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein
YLR141W4.141.71E-50.12RRN5Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
YGL044C4.022.90E-50.16RNA15Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
YLL018C3.865.71E-50.20DPS1Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation
YDL141W3.661.26E-40.37BPL1Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
YMR240C3.295.01E-40.12CUS1Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
YJL054W3.177.73E-40.06TIM54Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
YOR181W3.119.45E-40.03LAS17Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
YDR188W3.080.001030.06CCT6Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
YNL131W3.020.001250.08TOM22Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
YDL092W2.950.001610.08SRP14Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14
YDR087C2.870.002064.45E-4RRP1Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
YPR142C_d2.870.002070.00YPR142C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
YIL068C2.870.002080.18SEC6Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR423C5.492.05E-8CAD1AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication
YOR111W_p5.422.91E-8YOR111W_pPutative protein of unknown function
YFL013C5.267.39E-8IES1Subunit of the INO80 chromatin remodeling complex
YMR265C_p5.091.79E-7YMR265C_pPutative protein of unknown function
YBR171W4.953.74E-7SEC66Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YDR092W4.817.37E-7UBC13Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
YNL196C_p4.721.17E-6SLZ1_pSporulation-specific protein with a leucine zipper motif
YCR098C4.691.33E-6GIT1Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
YOL105C4.651.62E-6WSC3Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis
YBR046C4.621.92E-6ZTA1NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin
YLR294C_d4.523.13E-6YLR294C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14
YPR153W4.327.73E-6YPR153WPutative protein of unknown function
YDR281C4.022.94E-5PHM6Protein of unknown function, expression is regulated by phosphate levels
YMR305C3.963.76E-5SCW10Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YPR166C3.963.81E-5MRP2Mitochondrial ribosomal protein of the small subunit

GO enrichment analysis for SGTC_1889
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0741.21E-8SGTC_1826st055655 41.6 μMTimTec (Natural product derivative library)6761680.0857143ERG2
0.0741.54E-8SGTC_5274476-4215 268.0 μMChemDiv (Drug-like library)44187540.108434PDR1
0.0612.80E-6SGTC_28769059903 26.0 μMChembridge (Drug-like library)69160950.0923077
0.0613.22E-6SGTC_12430416-0003 5.7 μMChemDiv (Drug-like library)21419770.117647PDR1
0.0603.85E-6SGTC_2131246-0773 967.0 nMChemDiv (Drug-like library)62516220.0958904
0.0588.64E-6SGTC_349k015-0014 24.0 μMChemDiv (Drug-like library)21969080.131148
0.0534.67E-5SGTC_406estrone 100.0 μMMiscellaneous58700.15873
0.0534.84E-5SGTC_5163992-2719 87.3 μMChemDiv (Drug-like library)53508870.240741
0.0535.23E-5SGTC_1992st073643 23.3 μMTimTec (Natural product derivative library)31612920.056338mitochondrial processes
0.0526.78E-5SGTC_295k015-0027 31.0 μMChemDiv (Drug-like library)38874240.0923077PDR1
0.0517.64E-5SGTC_1647st011722 22.4 μMTimTec (Natural product derivative library)28547830.277778
0.0518.98E-5SGTC_676falcarinol 140.0 μMMiscellaneous33220.0153846
0.0511.03E-4SGTC_1700st030840 7.9 μMTimTec (Natural product derivative library)54993070.0595238PDR1
0.0501.23E-4SGTC_28237987624 58.4 μMChembridge (Drug-like library)22394400.0645161
0.0491.77E-4SGTC_2605digitonin 300.0 nMTimTec (Pure natural product library)27350100.0350877

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_15372',6'-dihydroxyflavanone78 μM0.743595106787TimTec (Pure natural product library)256.253382.61524
SGTC_16014'-hydroxyflavanone55.5 μM0.641026165506TimTec (Pure natural product library)240.253982.85713RPP1 & pyrimidine depletion
SGTC_1923st05845819.1 μM0.5952383534982TimTec (Natural product derivative library)240.253982.85713
SGTC_1970st07012235.8 μM0.522727102928TimTec (Natural product derivative library)254.280563.08303TSC3-RPN4
SGTC_15382',3',6-trimethoxyflavanone63.6 μM0.4150944213774TimTec (Pure natural product library)314.332523.0505
SGTC_1830st05598250.3 μM0.363636455313TimTec (Natural product derivative library)254.23752.35624
SGTC_15465-methoxyflavanone78.7 μM0.36147795TimTec (Pure natural product library)254.280563.08303
SGTC_1863st05764120.1 μM0.3333333921635TimTec (Natural product derivative library)270.279962.61414
SGTC_1693xanthone101.9 μM0.3157897020TimTec (Natural product derivative library)196.201422.96402DNA damage response
SGTC_2532xanthone78.9 μM0.3157897020Microsource (Natural product library)196.201422.96402
SGTC_1950st0771067.18 μM0.30882413831864TimTec (Natural product derivative library)408.486825.90635RNA processing & uracil transport