Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YPR110C | 6.25 | 2.01E-10 | 1.15 | RPC40 | RNA polymerase subunit AC40, common to RNA polymerase I and III |
YOR232W | 5.11 | 1.64E-7 | 0.77 | MGE1 | Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE |
YPL209C | 4.33 | 7.34E-6 | 0.41 | IPL1 | Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest |
YBL092W | 3.92 | 4.35E-5 | 0.07 | RPL32 | Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog |
YHR197W | 3.85 | 5.82E-5 | 0.08 | RIX1 | Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene |
YMR240C | 3.78 | 7.93E-5 | 0.04 | CUS1 | Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p |
YNL251C | 3.73 | 9.47E-5 | 0.11 | NRD1 | RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5, to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites |
YHR148W | 3.62 | 1.45E-4 | 0.02 | IMP3 | Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA |
YKL173W | 3.61 | 1.55E-4 | 0.12 | SNU114 | GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2 |
YMR213W | 3.48 | 2.48E-4 | 0.01 | CEF1 | Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p |
YGR246C | 3.48 | 2.55E-4 | 0.05 | BRF1 | TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB |
YGR251W | 3.43 | 3.06E-4 | 0.17 | NOP19 | Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes |
YMR229C | 3.25 | 5.72E-4 | 0.03 | RRP5 | RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress |
YBL034C | 3.22 | 6.37E-4 | 0.01 | STU1 | Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles |
YDL108W | 3.21 | 6.66E-4 | 0.04 | KIN28 | Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters |