Deletion Strain | FD score | P-value | Gene | Gene Description |
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YEL029C | 8.22 | 9.90E-17 | BUD16 | Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) |
YCR107W | 5.96 | 1.26E-9 | AAD3 | Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role |
YBL032W | 5.56 | 1.38E-8 | HEK2 | RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K |
YLR266C | 5.54 | 1.54E-8 | PDR8 | Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication |
YDR289C | 5.09 | 1.79E-7 | RTT103 | Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition |
YGL115W | 5.01 | 2.74E-7 | SNF4 | Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress |
YPL013C | 4.62 | 1.93E-6 | MRPS16 | Mitochondrial ribosomal protein of the small subunit |
YPL060W | 4.34 | 7.26E-6 | MFM1 | Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p |
YCR087C-A_p | 4.12 | 1.90E-5 | YCR087C-A_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene |
YGR197C | 4.10 | 2.08E-5 | SNG1 | Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance |
YBL027W | 3.99 | 3.28E-5 | RPL19B | Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication |
YNL035C_p | 3.96 | 3.77E-5 | YNL035C_p | Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress |
YBL062W_d | 3.77 | 8.04E-5 | YBL062W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YJR122W | 3.73 | 9.75E-5 | IBA57 | Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system |
YOL105C | 3.72 | 9.78E-5 | WSC3 | Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis |