Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPL169C | 9.90 | 2.13E-23 | 4.64 | MEX67 | Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP |
YJL156C | 5.26 | 7.13E-8 | 0.56 | SSY5 | Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p |
YLR145W | 4.71 | 1.27E-6 | 0.10 | RMP1 | Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P |
YLR033W | 4.60 | 2.11E-6 | 0.61 | RSC58 | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
YGL137W | 3.99 | 3.34E-5 | 0.22 | SEC27 | Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP |
YKL186C | 3.76 | 8.34E-5 | 0.08 | MTR2 | mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA |
YFR037C | 3.68 | 1.16E-4 | 0.24 | RSC8 | Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters |
YNL258C | 3.44 | 2.88E-4 | 0.21 | DSL1 | Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; similar to the fly and human ZW10 gene |
YOL005C | 3.24 | 6.06E-4 | 0.03 | RPB11 | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit |
YKL125W | 3.21 | 6.67E-4 | 0.16 | RRN3 | Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo |
YDL105W | 3.05 | 0.00116 | 0.13 | NSE4 | Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair |
YPR110C | 2.91 | 0.00179 | 0.07 | RPC40 | RNA polymerase subunit AC40, common to RNA polymerase I and III |
YJL194W | 2.85 | 0.00222 | 0.04 | CDC6 | Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress |
YFL017W-A | 2.81 | 0.00247 | 0.01 | SMX2 | Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G |
YLR153C | 2.80 | 0.00252 | 0.05 | ACS2 | Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions |