st060206

4-prop-2-enoxychromen-2-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1906
Screen concentration 94.7 μM
Source TimTec (Natural product derivative library)
PubChem CID 5133468
SMILES C=CCOC1=CC(=O)OC2=CC=CC=C21
Standardized SMILES C=CCOC1=CC(=O)Oc2ccccc12
Molecular weight 202.206
ALogP 2.2
H-bond donor count 0
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 11.79
% growth inhibition (Hom. pool) 11.16


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5133468
Download HIP data (tab-delimited text)  (excel)
Gene:APC4(YDR118W)|FD-Score:3.31|P-value:4.63E-4|Clearance:0.01||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress Gene:ARP9(YMR033W)|FD-Score:-3.13|P-value:8.60E-4|Clearance:0||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:CCT6(YDR188W)|FD-Score:-3.32|P-value:4.46E-4|Clearance:0||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif Gene:COF1(YLL050C)|FD-Score:4.21|P-value:1.27E-5|Clearance:0.28||SGD DESC:Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes Gene:ERG12(YMR208W)|FD-Score:3.14|P-value:8.52E-4|Clearance:0.03||SGD DESC:Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate Gene:GCD2(YGR083C)|FD-Score:-6.12|P-value:4.80E-10|Clearance:0||SGD DESC:Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Gene:POL2(YNL262W)|FD-Score:3.3|P-value:4.78E-4|Clearance:0.17||SGD DESC:Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p Gene:RPB10(YOR210W)|FD-Score:-3.22|P-value:6.32E-4|Clearance:0||SGD DESC:RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III Gene:RPC53(YDL150W)|FD-Score:-3.74|P-value:9.27E-5|Clearance:0||SGD DESC:RNA polymerase III subunit C53 Gene:RPC82(YPR190C)|FD-Score:-3.78|P-value:7.95E-5|Clearance:0||SGD DESC:RNA polymerase III subunit C82 Gene:RPP1(YHR062C)|FD-Score:-3.13|P-value:8.63E-4|Clearance:0||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:RRS1(YOR294W)|FD-Score:3.11|P-value:9.42E-4|Clearance:0.05||SGD DESC:Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice Gene:SGD1(YLR336C)|FD-Score:4.84|P-value:6.47E-7|Clearance:0.63||SGD DESC:Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia Gene:UFD1(YGR048W)|FD-Score:3.94|P-value:4.15E-5|Clearance:0.39||SGD DESC:Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP) Gene:YDR187C(YDR187C_d)|FD-Score:-3.78|P-value:7.77E-5|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W Gene:YDR526C(YDR526C_d)|FD-Score:-3.13|P-value:8.78E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR140W(YLR140W_d)|FD-Score:3.55|P-value:1.95E-4|Clearance:0.24||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I Gene:APC4(YDR118W)|FD-Score:3.31|P-value:4.63E-4|Clearance:0.01||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress Gene:ARP9(YMR033W)|FD-Score:-3.13|P-value:8.60E-4|Clearance:0||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:CCT6(YDR188W)|FD-Score:-3.32|P-value:4.46E-4|Clearance:0||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif Gene:COF1(YLL050C)|FD-Score:4.21|P-value:1.27E-5|Clearance:0.28||SGD DESC:Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes Gene:ERG12(YMR208W)|FD-Score:3.14|P-value:8.52E-4|Clearance:0.03||SGD DESC:Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate Gene:GCD2(YGR083C)|FD-Score:-6.12|P-value:4.80E-10|Clearance:0||SGD DESC:Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Gene:POL2(YNL262W)|FD-Score:3.3|P-value:4.78E-4|Clearance:0.17||SGD DESC:Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p Gene:RPB10(YOR210W)|FD-Score:-3.22|P-value:6.32E-4|Clearance:0||SGD DESC:RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III Gene:RPC53(YDL150W)|FD-Score:-3.74|P-value:9.27E-5|Clearance:0||SGD DESC:RNA polymerase III subunit C53 Gene:RPC82(YPR190C)|FD-Score:-3.78|P-value:7.95E-5|Clearance:0||SGD DESC:RNA polymerase III subunit C82 Gene:RPP1(YHR062C)|FD-Score:-3.13|P-value:8.63E-4|Clearance:0||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:RRS1(YOR294W)|FD-Score:3.11|P-value:9.42E-4|Clearance:0.05||SGD DESC:Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice Gene:SGD1(YLR336C)|FD-Score:4.84|P-value:6.47E-7|Clearance:0.63||SGD DESC:Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia Gene:UFD1(YGR048W)|FD-Score:3.94|P-value:4.15E-5|Clearance:0.39||SGD DESC:Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP) Gene:YDR187C(YDR187C_d)|FD-Score:-3.78|P-value:7.77E-5|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W Gene:YDR526C(YDR526C_d)|FD-Score:-3.13|P-value:8.78E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR140W(YLR140W_d)|FD-Score:3.55|P-value:1.95E-4|Clearance:0.24||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5133468
Download HOP data (tab-delimited text)  (excel)
Gene:AIM7(YDR063W)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss Gene:ARI1(YGL157W)|FD-Score:3.19|P-value:7.16E-4||SGD DESC:NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily Gene:ARN2(YHL047C)|FD-Score:3.17|P-value:7.65E-4||SGD DESC:Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C Gene:ARP6(YLR085C)|FD-Score:-4.44|P-value:4.44E-6||SGD DESC:Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:ATF1(YOR377W)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism Gene:BAS1(YKR099W)|FD-Score:3.45|P-value:2.81E-4||SGD DESC:Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes Gene:BUD16(YEL029C)|FD-Score:-5.85|P-value:2.42E-9||SGD DESC:Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) Gene:COG8(YML071C)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CRN1(YLR429W)|FD-Score:3.22|P-value:6.34E-4||SGD DESC:Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly Gene:CSF1(YLR087C)|FD-Score:-3.52|P-value:2.13E-4||SGD DESC:Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:CST9(YLR394W)|FD-Score:4.22|P-value:1.21E-5||SGD DESC:SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate Gene:DUG2(YBR281C)|FD-Score:3.35|P-value:4.03E-4||SGD DESC:Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) Gene:EAP1(YKL204W)|FD-Score:4.52|P-value:3.11E-6||SGD DESC:eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade Gene:EXG2(YDR261C)|FD-Score:3.19|P-value:7.06E-4||SGD DESC:Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor Gene:FMP41(YNL168C_p)|FD-Score:3.24|P-value:5.99E-4||SGD DESC:Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GCN2(YDR283C)|FD-Score:5.11|P-value:1.63E-7||SGD DESC:Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control Gene:GCN4(YEL009C)|FD-Score:6.07|P-value:6.35E-10||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GFD1(YMR255W)|FD-Score:3.47|P-value:2.56E-4||SGD DESC:Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress Gene:GNP1(YDR508C)|FD-Score:3.24|P-value:6.05E-4||SGD DESC:High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication Gene:GTT2(YLL060C)|FD-Score:3.48|P-value:2.54E-4||SGD DESC:Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress Gene:HXT17(YNR072W)|FD-Score:4.32|P-value:7.90E-6||SGD DESC:Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose Gene:KAR5(YMR065W)|FD-Score:4|P-value:3.14E-5||SGD DESC:Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone Gene:KES1(YPL145C)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication Gene:MBB1(YJL199C_d)|FD-Score:-3.93|P-value:4.32E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies Gene:MDL1(YLR188W)|FD-Score:3.2|P-value:6.78E-4||SGD DESC:Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress Gene:MRP2(YPR166C)|FD-Score:4.93|P-value:4.14E-7||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MUS81(YDR386W)|FD-Score:4.91|P-value:4.48E-7||SGD DESC:Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p Gene:PDE2(YOR360C)|FD-Score:3.57|P-value:1.80E-4||SGD DESC:High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon Gene:PET111(YMR257C)|FD-Score:3.17|P-value:7.68E-4||SGD DESC:Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane Gene:PHM8(YER037W)|FD-Score:4.01|P-value:3.08E-5||SGD DESC:Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p Gene:PKH3(YDR466W)|FD-Score:-3.21|P-value:6.69E-4||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:PRR2(YDL214C)|FD-Score:3.22|P-value:6.39E-4||SGD DESC:Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance Gene:RAD57(YDR004W)|FD-Score:-3.11|P-value:9.50E-4||SGD DESC:Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p Gene:RIM15(YFL033C)|FD-Score:3.23|P-value:6.09E-4||SGD DESC:Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase Gene:RPL19B(YBL027W)|FD-Score:-4.4|P-value:5.43E-6||SGD DESC:Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication Gene:RPL23A(YBL087C)|FD-Score:4.79|P-value:8.51E-7||SGD DESC:Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:-3.64|P-value:1.35E-4||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RRT5(YFR032C_p)|FD-Score:3.84|P-value:6.22E-5||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation Gene:RTT106(YNL206C)|FD-Score:3.15|P-value:8.15E-4||SGD DESC:Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition Gene:SCJ1(YMR214W)|FD-Score:-3.11|P-value:9.25E-4||SGD DESC:One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins Gene:SEF1(YBL066C)|FD-Score:3.23|P-value:6.27E-4||SGD DESC:Putative transcription factor, has homolog in Kluyveromyces lactis Gene:SGF73(YGL066W)|FD-Score:3.38|P-value:3.63E-4||SGD DESC:SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay Gene:SLX1(YBR228W)|FD-Score:-4.03|P-value:2.83E-5||SGD DESC:Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p Gene:SNC2(YOR327C)|FD-Score:3.1|P-value:9.71E-4||SGD DESC:Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication Gene:SPG4(YMR107W)|FD-Score:3.53|P-value:2.08E-4||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources Gene:SPT2(YER161C)|FD-Score:10.4|P-value:1.94E-25||SGD DESC:Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins Gene:STP2(YHR006W)|FD-Score:4.15|P-value:1.63E-5||SGD DESC:Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication Gene:SYH1(YPL105C)|FD-Score:-3.67|P-value:1.23E-4||SGD DESC:Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication Gene:TEF4(YKL081W)|FD-Score:-3.66|P-value:1.28E-4||SGD DESC:Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex Gene:TRP4(YDR354W)|FD-Score:5.13|P-value:1.45E-7||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:TRP5(YGL026C)|FD-Score:5.5|P-value:1.94E-8||SGD DESC:Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis Gene:XRS2(YDR369C)|FD-Score:3.23|P-value:6.09E-4||SGD DESC:Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling Gene:YCL074W(YCL074W)|FD-Score:4.2|P-value:1.34E-5||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YDR008C(YDR008C_d)|FD-Score:5.63|P-value:9.21E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YER076C(YER076C_p)|FD-Score:3.77|P-value:8.24E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization Gene:YET1(YKL065C)|FD-Score:3.2|P-value:6.86E-4||SGD DESC:Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein Gene:YFL042C(YFL042C_p)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Putative protein of unknown function; YFL042C is not an essential gene Gene:YGL132W(YGL132W_d)|FD-Score:3.18|P-value:7.35E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C Gene:YGR012W(YGR012W)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Putative cysteine synthase, localized to the mitochondrial outer membrane Gene:YGR122W(YGR122W)|FD-Score:-3.34|P-value:4.13E-4||SGD DESC:Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress Gene:YGR283C(YGR283C)|FD-Score:5.14|P-value:1.37E-7||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus Gene:YHR139C-A(YHR139C-A_d)|FD-Score:7.3|P-value:1.47E-13||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIR020C(YIR020C_p)|FD-Score:3.3|P-value:4.83E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YJU3(YKL094W)|FD-Score:3.87|P-value:5.50E-5||SGD DESC:Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family Gene:YLR012C(YLR012C_p)|FD-Score:-4.22|P-value:1.22E-5||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YLR241W(YLR241W_p)|FD-Score:4.17|P-value:1.55E-5||SGD DESC:Putative protein of unknown function, may be involved in detoxification Gene:YNL024C(YNL024C_p)|FD-Score:3.3|P-value:4.88E-4||SGD DESC:Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern Gene:YOL162W(YOL162W_p)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YOR015W(YOR015W_d)|FD-Score:-3.17|P-value:7.52E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR225W(YOR225W_d)|FD-Score:3.16|P-value:7.92E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPL225W(YPL225W)|FD-Score:-3.11|P-value:9.33E-4||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:YPR003C(YPR003C_p)|FD-Score:-3.81|P-value:6.98E-5||SGD DESC:Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene Gene:YPS7(YDR349C)|FD-Score:3.56|P-value:1.85E-4||SGD DESC:Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum Gene:AIM7(YDR063W)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss Gene:ARI1(YGL157W)|FD-Score:3.19|P-value:7.16E-4||SGD DESC:NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily Gene:ARN2(YHL047C)|FD-Score:3.17|P-value:7.65E-4||SGD DESC:Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C Gene:ARP6(YLR085C)|FD-Score:-4.44|P-value:4.44E-6||SGD DESC:Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:ATF1(YOR377W)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism Gene:BAS1(YKR099W)|FD-Score:3.45|P-value:2.81E-4||SGD DESC:Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes Gene:BUD16(YEL029C)|FD-Score:-5.85|P-value:2.42E-9||SGD DESC:Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) Gene:COG8(YML071C)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CRN1(YLR429W)|FD-Score:3.22|P-value:6.34E-4||SGD DESC:Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly Gene:CSF1(YLR087C)|FD-Score:-3.52|P-value:2.13E-4||SGD DESC:Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:CST9(YLR394W)|FD-Score:4.22|P-value:1.21E-5||SGD DESC:SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate Gene:DUG2(YBR281C)|FD-Score:3.35|P-value:4.03E-4||SGD DESC:Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) Gene:EAP1(YKL204W)|FD-Score:4.52|P-value:3.11E-6||SGD DESC:eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade Gene:EXG2(YDR261C)|FD-Score:3.19|P-value:7.06E-4||SGD DESC:Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor Gene:FMP41(YNL168C_p)|FD-Score:3.24|P-value:5.99E-4||SGD DESC:Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GCN2(YDR283C)|FD-Score:5.11|P-value:1.63E-7||SGD DESC:Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control Gene:GCN4(YEL009C)|FD-Score:6.07|P-value:6.35E-10||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GFD1(YMR255W)|FD-Score:3.47|P-value:2.56E-4||SGD DESC:Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress Gene:GNP1(YDR508C)|FD-Score:3.24|P-value:6.05E-4||SGD DESC:High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication Gene:GTT2(YLL060C)|FD-Score:3.48|P-value:2.54E-4||SGD DESC:Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress Gene:HXT17(YNR072W)|FD-Score:4.32|P-value:7.90E-6||SGD DESC:Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose Gene:KAR5(YMR065W)|FD-Score:4|P-value:3.14E-5||SGD DESC:Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone Gene:KES1(YPL145C)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication Gene:MBB1(YJL199C_d)|FD-Score:-3.93|P-value:4.32E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies Gene:MDL1(YLR188W)|FD-Score:3.2|P-value:6.78E-4||SGD DESC:Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress Gene:MRP2(YPR166C)|FD-Score:4.93|P-value:4.14E-7||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MUS81(YDR386W)|FD-Score:4.91|P-value:4.48E-7||SGD DESC:Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p Gene:PDE2(YOR360C)|FD-Score:3.57|P-value:1.80E-4||SGD DESC:High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon Gene:PET111(YMR257C)|FD-Score:3.17|P-value:7.68E-4||SGD DESC:Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane Gene:PHM8(YER037W)|FD-Score:4.01|P-value:3.08E-5||SGD DESC:Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p Gene:PKH3(YDR466W)|FD-Score:-3.21|P-value:6.69E-4||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:PRR2(YDL214C)|FD-Score:3.22|P-value:6.39E-4||SGD DESC:Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance Gene:RAD57(YDR004W)|FD-Score:-3.11|P-value:9.50E-4||SGD DESC:Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p Gene:RIM15(YFL033C)|FD-Score:3.23|P-value:6.09E-4||SGD DESC:Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase Gene:RPL19B(YBL027W)|FD-Score:-4.4|P-value:5.43E-6||SGD DESC:Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication Gene:RPL23A(YBL087C)|FD-Score:4.79|P-value:8.51E-7||SGD DESC:Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:-3.64|P-value:1.35E-4||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RRT5(YFR032C_p)|FD-Score:3.84|P-value:6.22E-5||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation Gene:RTT106(YNL206C)|FD-Score:3.15|P-value:8.15E-4||SGD DESC:Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition Gene:SCJ1(YMR214W)|FD-Score:-3.11|P-value:9.25E-4||SGD DESC:One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins Gene:SEF1(YBL066C)|FD-Score:3.23|P-value:6.27E-4||SGD DESC:Putative transcription factor, has homolog in Kluyveromyces lactis Gene:SGF73(YGL066W)|FD-Score:3.38|P-value:3.63E-4||SGD DESC:SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay Gene:SLX1(YBR228W)|FD-Score:-4.03|P-value:2.83E-5||SGD DESC:Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p Gene:SNC2(YOR327C)|FD-Score:3.1|P-value:9.71E-4||SGD DESC:Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication Gene:SPG4(YMR107W)|FD-Score:3.53|P-value:2.08E-4||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources Gene:SPT2(YER161C)|FD-Score:10.4|P-value:1.94E-25||SGD DESC:Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins Gene:STP2(YHR006W)|FD-Score:4.15|P-value:1.63E-5||SGD DESC:Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication Gene:SYH1(YPL105C)|FD-Score:-3.67|P-value:1.23E-4||SGD DESC:Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication Gene:TEF4(YKL081W)|FD-Score:-3.66|P-value:1.28E-4||SGD DESC:Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex Gene:TRP4(YDR354W)|FD-Score:5.13|P-value:1.45E-7||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:TRP5(YGL026C)|FD-Score:5.5|P-value:1.94E-8||SGD DESC:Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis Gene:XRS2(YDR369C)|FD-Score:3.23|P-value:6.09E-4||SGD DESC:Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling Gene:YCL074W(YCL074W)|FD-Score:4.2|P-value:1.34E-5||SGD DESC:Pseudogene: encodes fragment of Ty Pol protein Gene:YDR008C(YDR008C_d)|FD-Score:5.63|P-value:9.21E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YER076C(YER076C_p)|FD-Score:3.77|P-value:8.24E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization Gene:YET1(YKL065C)|FD-Score:3.2|P-value:6.86E-4||SGD DESC:Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein Gene:YFL042C(YFL042C_p)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Putative protein of unknown function; YFL042C is not an essential gene Gene:YGL132W(YGL132W_d)|FD-Score:3.18|P-value:7.35E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C Gene:YGR012W(YGR012W)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Putative cysteine synthase, localized to the mitochondrial outer membrane Gene:YGR122W(YGR122W)|FD-Score:-3.34|P-value:4.13E-4||SGD DESC:Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress Gene:YGR283C(YGR283C)|FD-Score:5.14|P-value:1.37E-7||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus Gene:YHR139C-A(YHR139C-A_d)|FD-Score:7.3|P-value:1.47E-13||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIR020C(YIR020C_p)|FD-Score:3.3|P-value:4.83E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YJU3(YKL094W)|FD-Score:3.87|P-value:5.50E-5||SGD DESC:Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family Gene:YLR012C(YLR012C_p)|FD-Score:-4.22|P-value:1.22E-5||SGD DESC:Putative protein of unknown function; YLR012C is not an essential gene Gene:YLR241W(YLR241W_p)|FD-Score:4.17|P-value:1.55E-5||SGD DESC:Putative protein of unknown function, may be involved in detoxification Gene:YNL024C(YNL024C_p)|FD-Score:3.3|P-value:4.88E-4||SGD DESC:Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern Gene:YOL162W(YOL162W_p)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YOR015W(YOR015W_d)|FD-Score:-3.17|P-value:7.52E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR225W(YOR225W_d)|FD-Score:3.16|P-value:7.92E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPL225W(YPL225W)|FD-Score:-3.11|P-value:9.33E-4||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:YPR003C(YPR003C_p)|FD-Score:-3.81|P-value:6.98E-5||SGD DESC:Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene Gene:YPS7(YDR349C)|FD-Score:3.56|P-value:1.85E-4||SGD DESC:Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum

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Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR336C4.846.47E-70.63SGD1Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia
YLL050C4.211.27E-50.28COF1Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
YGR048W3.944.15E-50.39UFD1Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
YLR140W_d3.551.95E-40.23YLR140W_dDubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I
YDR118W3.314.63E-40.01APC4Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
YNL262W3.304.78E-40.17POL2Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
YMR208W3.148.52E-40.03ERG12Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YOR294W3.119.42E-40.05RRS1Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
YBR135W3.060.001110.02CKS1Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
YDR407C3.040.001190.16TRS120One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YGL247W2.880.002010.19BRR6Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism
YJL085W2.690.003570.04EXO70Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
YPL252C2.650.003970.06YAH1Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
YOR361C2.590.004730.05PRT1eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
YOR287C2.540.005520.03RRP36Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YER161C10.401.94E-25SPT2Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins
YHR139C-A_d7.301.47E-13YHR139C-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL009C6.076.35E-10GCN4Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YDR008C_d5.639.21E-9YDR008C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL026C5.501.94E-8TRP5Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
YGR283C5.141.37E-7YGR283CPutative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus
YDR354W5.131.45E-7TRP4Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
YDR283C5.111.63E-7GCN2Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
YPR166C4.934.14E-7MRP2Mitochondrial ribosomal protein of the small subunit
YDR386W4.914.48E-7MUS81Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
YBL087C4.798.51E-7RPL23ARibosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication
YKL204W4.523.11E-6EAP1eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade
YNR072W4.327.90E-6HXT17Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YLR394W4.221.21E-5CST9SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate
YCL074W4.201.34E-5YCL074WPseudogene: encodes fragment of Ty Pol protein

GO enrichment analysis for SGTC_1906
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.2195.16E-65SGTC_2650prasterone 100.0 μMMicrosource (Natural product library)167592470.0597015
0.2022.25E-55SGTC_1572epiandrosterone 68.9 μMTimTec (Pure natural product library)4413020.0441176
0.2002.30E-54SGTC_18825615643 20.0 μMMiscellaneous22530750.0921053TRP & mitochondrial translation
0.1909.60E-49SGTC_2642cholecalciferol 100.0 μMMicrosource (Natural product library)98214650.0487805
0.1811.89E-44SGTC_18835-benzylidenerhodanine 20.0 μMMiscellaneous12732100.150943TRP & mitochondrial translation
0.1803.35E-44SGTC_2758dehydroepiandrosterone 69.3 μMMiscellaneous58810.0597015
0.1763.69E-42SGTC_12191469-0211 33.1 μMChemDiv (Drug-like library)68222820.0675676
0.1759.89E-42SGTC_1697st025554 27.7 μMTimTec (Natural product derivative library)12695190.133333
0.1738.60E-41SGTC_24785763493 32.3 μMMiscellaneous13655760.111111
0.1721.54E-40SGTC_511013-0126 23.4 μMChemDiv (Drug-like library)16278500.121212
0.1654.00E-37SGTC_18815652484 16.0 μMMiscellaneous22551290.108108TRP & mitochondrial translation
0.1641.46E-36SGTC_1649st011737 51.3 μMTimTec (Natural product derivative library)17610350.102941
0.1611.48E-35SGTC_1617st002906 78.0 μMTimTec (Natural product derivative library)51508590.0377358
0.1604.52E-35SGTC_33089128332 17.6 μMChembridge (Drug-like library)173328050.101449plasma membrane duress
0.1591.56E-34SGTC_6770929-0063 136.0 μMChemDiv (Drug-like library)15395830.116667

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_1905st06020784.5 μM0.5217391948547TimTec (Natural product derivative library)216.232582.94603
SGTC_7844579-0127173 μM0.5217391948547ChemDiv (Drug-like library)216.232582.94603
SGTC_1902st06021270.5 μM0.434783688944TimTec (Natural product derivative library)204.221882.42203
SGTC_1907st06021083.7 μM0.434783688793TimTec (Natural product derivative library)204.221882.42203
SGTC_1896st05844189 μM0.425532688759TimTec (Natural product derivative library)224.640362.603
SGTC_1911st06020874.3 μM0.425532688783TimTec (Natural product derivative library)269.091362.68403
SGTC_1913st06021396.1 μM0.425532688959TimTec (Natural product derivative library)208.1857632.14204
SGTC_1903st06021178.3 μM0.416667688960TimTec (Natural product derivative library)220.221281.9204
SGTC_1912st06020990.8 μM0.416667688787TimTec (Natural product derivative library)220.221281.9204
SGTC_1693xanthone101.9 μM0.3783787020TimTec (Natural product derivative library)196.201422.96402DNA damage response