3914-0123

3-[(6-bromo-4-phenylquinazolin-2-yl)amino]propan-1-ol

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_191
Screen concentration 66.5 μM
Source ChemDiv (Drug-like library)
PubChem CID 3144412
SMILES C1=CC=C(C=C1)C2=NC(=NC3=C2C=C(C=C3)Br)NCCCO
Standardized SMILES OCCCNc1nc(c2ccccc2)c3cc(Br)ccc3n1
Molecular weight 358.2324
ALogP 3.94
H-bond donor count 2
H-bond acceptor count 4
Response signature 60S ribosome export

Pool Growth Kinetics
% growth inhibition (Het. pool) 26.39
% growth inhibition (Hom. pool) 9.85


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3144412
Download HIP data (tab-delimited text)  (excel)
Gene:ABF1(YKL112W)|FD-Score:3.22|P-value:6.30E-4|Clearance:0.01||SGD DESC:DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair Gene:BET4(YJL031C)|FD-Score:-3.21|P-value:6.55E-4|Clearance:0||SGD DESC:Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p Gene:CDC21(YOR074C)|FD-Score:4.29|P-value:9.10E-6|Clearance:0.75||SGD DESC:Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S Gene:LSG1(YGL099W)|FD-Score:6.76|P-value:6.82E-12|Clearance:1.23||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:NMD3(YHR170W)|FD-Score:8.08|P-value:3.26E-16|Clearance:1.32||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:NSA2(YER126C)|FD-Score:3.13|P-value:8.84E-4|Clearance:0||SGD DESC:Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA Gene:POP8(YBL018C)|FD-Score:3.12|P-value:8.99E-4|Clearance:0.04||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:SEC31(YDL195W)|FD-Score:5.06|P-value:2.07E-7|Clearance:0.78||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:SPB1(YCL054W)|FD-Score:3.54|P-value:2.01E-4|Clearance:0.31||SGD DESC:AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants Gene:TAF11(YML015C)|FD-Score:5.53|P-value:1.59E-8|Clearance:0.47||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:YAH1(YPL252C)|FD-Score:3.22|P-value:6.50E-4|Clearance:0.09||SGD DESC:Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin Gene:ABF1(YKL112W)|FD-Score:3.22|P-value:6.30E-4|Clearance:0.01||SGD DESC:DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair Gene:BET4(YJL031C)|FD-Score:-3.21|P-value:6.55E-4|Clearance:0||SGD DESC:Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p Gene:CDC21(YOR074C)|FD-Score:4.29|P-value:9.10E-6|Clearance:0.75||SGD DESC:Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S Gene:LSG1(YGL099W)|FD-Score:6.76|P-value:6.82E-12|Clearance:1.23||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:NMD3(YHR170W)|FD-Score:8.08|P-value:3.26E-16|Clearance:1.32||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:NSA2(YER126C)|FD-Score:3.13|P-value:8.84E-4|Clearance:0||SGD DESC:Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA Gene:POP8(YBL018C)|FD-Score:3.12|P-value:8.99E-4|Clearance:0.04||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:SEC31(YDL195W)|FD-Score:5.06|P-value:2.07E-7|Clearance:0.78||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:SPB1(YCL054W)|FD-Score:3.54|P-value:2.01E-4|Clearance:0.31||SGD DESC:AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants Gene:TAF11(YML015C)|FD-Score:5.53|P-value:1.59E-8|Clearance:0.47||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:YAH1(YPL252C)|FD-Score:3.22|P-value:6.50E-4|Clearance:0.09||SGD DESC:Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3144412
Download HOP data (tab-delimited text)  (excel)
Gene:HER1(YOR227W)|FD-Score:3.21|P-value:6.64E-4||SGD DESC:Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication Gene:MDS3(YGL197W)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain Gene:PSH1(YOL054W)|FD-Score:-3.25|P-value:5.78E-4||SGD DESC:E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p Gene:RFM1(YOR279C)|FD-Score:3.42|P-value:3.19E-4||SGD DESC:DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance Gene:SRT1(YMR101C)|FD-Score:-4.15|P-value:1.63E-5||SGD DESC:Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase Gene:TMA23(YMR269W)|FD-Score:-3.48|P-value:2.55E-4||SGD DESC:Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan Gene:YBR051W(YBR051W_d)|FD-Score:-3.12|P-value:8.92E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase Gene:YCR100C(YCR100C_p)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:Putative protein of unknown function Gene:YNL194C(YNL194C)|FD-Score:3.31|P-value:4.74E-4||SGD DESC:Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate Gene:YOR072W(YOR072W_d)|FD-Score:5.77|P-value:4.06E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Gene:YOR228C(YOR228C)|FD-Score:3.19|P-value:7.18E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:HER1(YOR227W)|FD-Score:3.21|P-value:6.64E-4||SGD DESC:Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication Gene:MDS3(YGL197W)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain Gene:PSH1(YOL054W)|FD-Score:-3.25|P-value:5.78E-4||SGD DESC:E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p Gene:RFM1(YOR279C)|FD-Score:3.42|P-value:3.19E-4||SGD DESC:DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance Gene:SRT1(YMR101C)|FD-Score:-4.15|P-value:1.63E-5||SGD DESC:Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase Gene:TMA23(YMR269W)|FD-Score:-3.48|P-value:2.55E-4||SGD DESC:Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan Gene:YBR051W(YBR051W_d)|FD-Score:-3.12|P-value:8.92E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase Gene:YCR100C(YCR100C_p)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:Putative protein of unknown function Gene:YNL194C(YNL194C)|FD-Score:3.31|P-value:4.74E-4||SGD DESC:Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate Gene:YOR072W(YOR072W_d)|FD-Score:5.77|P-value:4.06E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Gene:YOR228C(YOR228C)|FD-Score:3.19|P-value:7.18E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR170W8.083.26E-161.32NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YGL099W6.766.82E-121.23LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YML015C5.531.59E-80.47TAF11TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors
YDL195W5.062.07E-70.78SEC31Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
YOR074C4.299.10E-60.75CDC21Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
YCL054W3.542.01E-40.31SPB1AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YKL112W3.226.30E-40.01ABF1DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
YPL252C3.226.50E-40.09YAH1Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
YER126C3.138.84E-40.00NSA2Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
YBL018C3.128.99E-40.04POP8Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YOR151C3.080.001050.11RPB2RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit
YBR011C2.970.001510.06IPP1Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YFR005C2.910.001820.01SAD1Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle
YDR050C2.900.001890.01TPI1Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
YGL245W2.880.001970.04GUS1Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR072W_d5.774.06E-9YOR072W_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YCR100C_p3.591.66E-4YCR100C_pPutative protein of unknown function
YGL197W3.452.84E-4MDS3Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain
YOR279C3.423.19E-4RFM1DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
YNL194C3.314.74E-4YNL194CIntegral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate
YOR227W3.216.64E-4HER1Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication
YOR228C3.197.18E-4YOR228CProtein of unknown function, localized to the mitochondrial outer membrane
YLR313C3.080.00105SPH1Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p
YLR320W3.040.00117MMS22Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation
YOR365C_p3.020.00124YOR365C_pPutative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication
YIL138C3.010.00131TPM2Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication
YJL129C3.010.00131TRK1Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
YCR099C_p3.000.00136YCR099C_pPutative protein of unknown function
YOL129W2.980.00145VPS68Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria
YNL100W2.960.00156AIM37Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture

GO enrichment analysis for SGTC_191
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.3211.75E-141SGTC_7651319-0117 244.0 μMChemDiv (Drug-like library)34877460.087912160S ribosome export
0.3082.31E-130SGTC_8103825-7150 143.0 μMChemDiv (Drug-like library)223304110.17567660S ribosome export
0.2813.77E-107SGTC_1070indatraline 8.8 μMNIH Clinical Collection103144720.10447860S ribosome export
0.2742.06E-102SGTC_618k072-0232 33.2 μMChemDiv (Drug-like library)58727560.11267660S ribosome export
0.2563.58E-89SGTC_1775st081588 35.2 μMTimTec (Natural product derivative library)14264430.070588260S ribosome export
0.2406.06E-78SGTC_8660495-0101 262.0 μMChemDiv (Drug-like library)6356940.062560S ribosome export
0.2357.40E-75SGTC_1983454-2873 16.2 μMChemDiv (Drug-like library)7109570.187560S ribosome export
0.2331.91E-73SGTC_1958st076513 41.9 μMTimTec (Natural product derivative library)7321220.11594260S ribosome export
0.2326.46E-73SGTC_1360097-0015 404.5 μMChemDiv (Drug-like library)48613370.061538560S ribosome export
0.2292.75E-71SGTC_970535-0701 19.1 μMChemDiv (Drug-like library)28320130.10666760S ribosome export
0.2281.36E-70SGTC_1664st014217 9.0 μMTimTec (Natural product derivative library)39827820.095238160S ribosome export
0.2245.61E-68SGTC_31709103054 49.5 μMChembridge (Drug-like library)164329700.18309960S ribosome export
0.2227.82E-67SGTC_31859108267 49.5 μMChembridge (Drug-like library)49104860.078651760S ribosome export
0.2208.25E-66SGTC_6450845-0943 5.4 μMChemDiv (Drug-like library)18851060.14285760S ribosome export
0.2159.63E-63SGTC_1663st014140 55.4 μMTimTec (Natural product derivative library)42071200.058823560S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1833914-005130.55 μM0.721596232ChemDiv (Drug-like library)392.67754.62460S ribosome export
SGTC_6133914-0030117 μM0.661145395ChemDiv (Drug-like library)358.189383.89425
SGTC_12063978-0017132 μM0.4153853873677ChemDiv (Drug-like library)469.331143.82816ERG2
SGTC_12931000-1278195 μM0.37931678847ChemDiv (Drug-like library)342.186683.16912
SGTC_3287911717337.06 μM0.3166672789709Chembridge (Drug-like library)329.82393.6692460S ribosome export
SGTC_348k064-001210.7 μM0.2982465066323ChemDiv (Drug-like library)367.2143835.8571360S ribosome export
SGTC_6653914-0008307 μM0.2957751069549ChemDiv (Drug-like library)404.461663.56616
SGTC_14504112-426037.6 μM0.2794121633175ChemDiv (Drug-like library)335.44274.06714calcium & mitochondrial duress
SGTC_8390122-0028230 μM0.267857759448ChemDiv (Drug-like library)265.149023.91711RSC complex & mRNA processing
SGTC_540159-00559 μM0.2615383319099ChemDiv (Drug-like library)530.476949.51910ERG2