| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YOR072W_d | 5.77 | 4.06E-9 | YOR072W_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive |
| YCR100C_p | 3.59 | 1.66E-4 | YCR100C_p | Putative protein of unknown function |
| YGL197W | 3.45 | 2.84E-4 | MDS3 | Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain |
| YOR279C | 3.42 | 3.19E-4 | RFM1 | DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance |
| YNL194C | 3.31 | 4.74E-4 | YNL194C | Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate |
| YOR227W | 3.21 | 6.64E-4 | HER1 | Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication |
| YOR228C | 3.19 | 7.18E-4 | YOR228C | Protein of unknown function, localized to the mitochondrial outer membrane |
| YLR313C | 3.08 | 0.00105 | SPH1 | Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p |
| YLR320W | 3.04 | 0.00117 | MMS22 | Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation |
| YOR365C_p | 3.02 | 0.00124 | YOR365C_p | Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication |
| YIL138C | 3.01 | 0.00131 | TPM2 | Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication |
| YJL129C | 3.01 | 0.00131 | TRK1 | Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication |
| YCR099C_p | 3.00 | 0.00136 | YCR099C_p | Putative protein of unknown function |
| YOL129W | 2.98 | 0.00145 | VPS68 | Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria |
| YNL100W | 2.96 | 0.00156 | AIM37 | Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture |
