Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YHR072W | 19.00 | 3.83E-81 | 10.10 | ERG7 | Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis |
YLR359W | 8.99 | 1.29E-19 | 3.42 | ADE13 | Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency |
YBR109C | 5.57 | 1.31E-8 | 0.69 | CMD1 | Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin |
YDR166C | 4.87 | 5.50E-7 | 0.64 | SEC5 | Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip |
YJL032W_d | 4.23 | 1.17E-5 | 0.32 | YJL032W_d | Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase |
YOL094C | 3.91 | 4.52E-5 | 0.13 | RFC4 | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |
YBR236C | 3.78 | 7.79E-5 | 0.30 | ABD1 | Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA |
YFL002C | 3.48 | 2.54E-4 | 0.17 | SPB4 | Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients |
YOR217W | 3.30 | 4.78E-4 | 0.04 | RFC1 | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |
YDR367W | 3.27 | 5.43E-4 | 0.02 | KEI1 | Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene |
YJL194W | 3.25 | 5.81E-4 | 0.47 | CDC6 | Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress |
YKL108W | 2.77 | 0.00276 | 0.05 | SLD2 | Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress |
YDR473C | 2.72 | 0.00325 | 0.01 | PRP3 | Splicing factor, component of the U4/U6-U5 snRNP complex |
YML043C | 2.72 | 0.00330 | 0.01 | RRN11 | Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p |
YMR240C | 2.70 | 0.00344 | 0.02 | CUS1 | Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p |