| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YNL024C_p | 6.76 | 7.05E-12 | YNL024C_p | Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern |
| YOR013W_d | 6.72 | 9.17E-12 | IRC11_d | Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci |
| YHR114W | 6.14 | 4.18E-10 | BZZ1 | SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins |
| YMR122C_d | 5.51 | 1.82E-8 | YMR122C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YER144C | 5.48 | 2.17E-8 | UBP5 | Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck |
| YOL018C | 5.37 | 3.94E-8 | TLG2 | Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) |
| YPL191C_p | 4.73 | 1.11E-6 | YPL191C_p | Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
| YKL086W | 4.70 | 1.33E-6 | SRX1 | Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress |
| YLR329W | 4.54 | 2.81E-6 | REC102 | Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination |
| YKL120W | 4.52 | 3.10E-6 | OAC1 | Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family |
| YKR104W | 4.44 | 4.46E-6 | YKR104W | Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds |
| YPL139C | 4.43 | 4.80E-6 | UME1 | Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p |
| YCL037C | 4.39 | 5.80E-6 | SRO9 | Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication |
| YDR151C | 4.27 | 9.86E-6 | CTH1 | Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis |
| YOL002C | 4.20 | 1.32E-5 | IZH2 | Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc |
