Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPL117C | 7.25 | 2.13E-13 | 1.16 | IDI1 | Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability |
YKL182W | 6.40 | 7.92E-11 | 1.16 | FAS1 | Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities |
YGL113W | 5.24 | 8.20E-8 | 0.19 | SLD3 | Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress |
YBR055C | 5.05 | 2.20E-7 | 0.03 | PRP6 | Splicing factor, component of the U4/U6-U5 snRNP complex |
YDR232W | 5.02 | 2.62E-7 | 0.43 | HEM1 | 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p |
YPL252C | 4.59 | 2.24E-6 | 0.13 | YAH1 | Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin |
YOR095C | 4.46 | 4.11E-6 | 0.06 | RKI1 | Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis |
YMR281W | 4.40 | 5.45E-6 | 0.48 | GPI12 | ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp |
YGL116W | 3.91 | 4.53E-5 | 0.20 | CDC20 | Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress |
YOR232W | 3.72 | 1.01E-4 | 0.15 | MGE1 | Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE |
YIL083C | 3.57 | 1.80E-4 | 0.11 | CAB2 | Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) |
YNR016C | 3.45 | 2.75E-4 | 0.04 | ACC1 | Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; |
YNL263C | 3.41 | 3.25E-4 | 0.02 | YIF1 | Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3 |
YPL122C | 3.39 | 3.52E-4 | 0.04 | TFB2 | Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH |
YLR010C | 3.35 | 4.09E-4 | 0.05 | TEN1 | Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p |