| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YFR033C | 7.75 | 4.53E-15 | QCR6 | Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space |
| YBR015C | 5.28 | 6.32E-8 | MNN2 | Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment |
| YDR323C | 5.27 | 6.94E-8 | PEP7 | Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance |
| YGL231C | 5.12 | 1.51E-7 | EMC4 | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85 |
| YHR202W_p | 5.10 | 1.68E-7 | YHR202W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization |
| YPR070W | 4.81 | 7.71E-7 | MED1 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation |
| YBL042C | 4.76 | 9.57E-7 | FUI1 | High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress |
| YDR158W | 4.74 | 1.08E-6 | HOM2 | Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis |
| YPR027C_p | 4.71 | 1.24E-6 | YPR027C_p | Putative protein of unknown function |
| YBR196C-B_p | 4.47 | 3.83E-6 | YBR196C-B_p | Putative protein of unknown function; identified by expression profiling and mass spectrometry |
| YLR185W | 4.44 | 4.51E-6 | RPL37A | Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication |
| YGL258W | 4.39 | 5.70E-6 | VEL1 | Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C |
| YGR222W | 4.10 | 2.07E-5 | PET54 | Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing |
| YOR014W | 3.86 | 5.71E-5 | RTS1 | B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A |
| YGR228W_d | 3.84 | 6.16E-5 | YGR228W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C |
