Deletion Strain | FD score | P-value | Gene | Gene Description |
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YPL195W | 7.05 | 9.16E-13 | APL5 | Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function |
YBR021W | 6.29 | 1.61E-10 | FUR4 | Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation |
YEL018W | 5.30 | 5.84E-8 | EAF5 | Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex |
YOL138C | 5.14 | 1.36E-7 | RTC1 | Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif |
YFR053C | 5.04 | 2.28E-7 | HXK1 | Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication |
YGR226C_d | 4.98 | 3.14E-7 | YGR226C_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W |
YJL089W | 4.92 | 4.35E-7 | SIP4 | C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus |
YPR123C_d | 4.88 | 5.42E-7 | YPR123C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR |
YGL007W_d | 4.82 | 7.07E-7 | BRP1_d | Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 |
YJL198W | 4.69 | 1.39E-6 | PHO90 | Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication |
YMR246W | 4.55 | 2.74E-6 | FAA4 | Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication |
YKL062W | 4.53 | 3.00E-6 | MSN4 | Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication |
YHR130C_d | 4.51 | 3.30E-6 | YHR130C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YDR290W_d | 4.29 | 9.13E-6 | YDR290W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103 |
YIL086C_d | 4.29 | 9.13E-6 | YIL086C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |