Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR354W | 13.20 | 2.77E-40 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
YER090W | 12.30 | 3.81E-35 | TRP2 | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p |
YDR008C_d | 10.50 | 2.60E-26 | YDR008C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YKL211C | 8.42 | 1.81E-17 | TRP3 | Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p |
YPL172C | 6.99 | 1.36E-12 | COX10 | Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders |
YGL117W_p | 6.67 | 1.26E-11 | YGL117W_p | Putative protein of unknown function |
YDL020C | 6.02 | 8.69E-10 | RPN4 | Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress |
YOR070C | 6.00 | 9.71E-10 | GYP1 | Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion |
YDR127W | 5.21 | 9.58E-8 | ARO1 | Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids |
YBR058C-A | 5.13 | 1.44E-7 | TSC3 | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
YOL052C-A | 4.95 | 3.63E-7 | DDR2 | Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication |
YPL065W | 4.92 | 4.35E-7 | VPS28 | Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p |
YHR100C | 4.86 | 5.75E-7 | GEP4 | Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT |
YGL186C | 4.84 | 6.49E-7 | TPN1 | Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p |
YPL137C | 4.80 | 8.06E-7 | GIP3 | Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication |