st077085

8-hydroxy-6-methoxy-7-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1956
Screen concentration 54.0 μM
Source TimTec (Natural product derivative library)
PubChem CID 24208685
SMILES COC1=C(C(=C2C(=C1)C=CC(=O)O2)O)OC3C(C(C(C(O3)CO)O)O)O
Standardized SMILES COc1cc2C=CC(=O)Oc2c(O)c1OC3OC(CO)C(O)C(O)C3O
Molecular weight 370.3081
ALogP -0.53
H-bond donor count 5
H-bond acceptor count 10
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.36
% growth inhibition (Hom. pool) 5.51


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 24208685
Download HIP data (tab-delimited text)  (excel)
Gene:CCT8(YJL008C)|FD-Score:3.1|P-value:9.72E-4|Clearance:0.02||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CIA1(YDR267C)|FD-Score:3.22|P-value:6.47E-4|Clearance:0||SGD DESC:Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein Gene:DBP2(YNL112W)|FD-Score:3.49|P-value:2.46E-4|Clearance:0.19||SGD DESC:ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites Gene:KRI1(YNL308C)|FD-Score:3.81|P-value:7.02E-5|Clearance:0.32||SGD DESC:Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p Gene:MIM1(YOL026C)|FD-Score:-3.5|P-value:2.32E-4|Clearance:0||SGD DESC:Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex Gene:NOP4(YPL043W)|FD-Score:3.18|P-value:7.48E-4|Clearance:0.08||SGD DESC:Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) Gene:RIB3(YDR487C)|FD-Score:-3.65|P-value:1.34E-4|Clearance:0||SGD DESC:3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration Gene:RNT1(YMR239C)|FD-Score:3.25|P-value:5.76E-4|Clearance:0.03||SGD DESC:Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes Gene:RPS3(YNL178W)|FD-Score:3.29|P-value:5.00E-4|Clearance:0.02||SGD DESC:Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 Gene:RRB1(YMR131C)|FD-Score:-3.54|P-value:1.99E-4|Clearance:0||SGD DESC:Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p Gene:RRP45(YDR280W)|FD-Score:3.27|P-value:5.33E-4|Clearance:0.01||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress Gene:SRP54(YPR088C)|FD-Score:-3.56|P-value:1.83E-4|Clearance:0||SGD DESC:Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain Gene:SWP1(YMR149W)|FD-Score:3.27|P-value:5.47E-4|Clearance:0.01||SGD DESC:Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum Gene:VAS1(YGR094W)|FD-Score:3.21|P-value:6.55E-4|Clearance:0.04||SGD DESC:Mitochondrial and cytoplasmic valyl-tRNA synthetase Gene:YLR076C(YLR076C_d)|FD-Score:4.88|P-value:5.42E-7|Clearance:1.07||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 Gene:CCT8(YJL008C)|FD-Score:3.1|P-value:9.72E-4|Clearance:0.02||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:CIA1(YDR267C)|FD-Score:3.22|P-value:6.47E-4|Clearance:0||SGD DESC:Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein Gene:DBP2(YNL112W)|FD-Score:3.49|P-value:2.46E-4|Clearance:0.19||SGD DESC:ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites Gene:KRI1(YNL308C)|FD-Score:3.81|P-value:7.02E-5|Clearance:0.32||SGD DESC:Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p Gene:MIM1(YOL026C)|FD-Score:-3.5|P-value:2.32E-4|Clearance:0||SGD DESC:Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex Gene:NOP4(YPL043W)|FD-Score:3.18|P-value:7.48E-4|Clearance:0.08||SGD DESC:Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) Gene:RIB3(YDR487C)|FD-Score:-3.65|P-value:1.34E-4|Clearance:0||SGD DESC:3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration Gene:RNT1(YMR239C)|FD-Score:3.25|P-value:5.76E-4|Clearance:0.03||SGD DESC:Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes Gene:RPS3(YNL178W)|FD-Score:3.29|P-value:5.00E-4|Clearance:0.02||SGD DESC:Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 Gene:RRB1(YMR131C)|FD-Score:-3.54|P-value:1.99E-4|Clearance:0||SGD DESC:Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p Gene:RRP45(YDR280W)|FD-Score:3.27|P-value:5.33E-4|Clearance:0.01||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress Gene:SRP54(YPR088C)|FD-Score:-3.56|P-value:1.83E-4|Clearance:0||SGD DESC:Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain Gene:SWP1(YMR149W)|FD-Score:3.27|P-value:5.47E-4|Clearance:0.01||SGD DESC:Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum Gene:VAS1(YGR094W)|FD-Score:3.21|P-value:6.55E-4|Clearance:0.04||SGD DESC:Mitochondrial and cytoplasmic valyl-tRNA synthetase Gene:YLR076C(YLR076C_d)|FD-Score:4.88|P-value:5.42E-7|Clearance:1.07||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 24208685
Download HOP data (tab-delimited text)  (excel)
Gene:AHA1(YDR214W)|FD-Score:3.48|P-value:2.51E-4||SGD DESC:Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress Gene:AIM4(YBR194W)|FD-Score:3.33|P-value:4.40E-4||SGD DESC:Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress Gene:AKR1(YDR264C)|FD-Score:4.36|P-value:6.63E-6||SGD DESC:Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication Gene:CHA4(YLR098C)|FD-Score:-3.22|P-value:6.34E-4||SGD DESC:DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain Gene:CHS6(YJL099W)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication Gene:CIT2(YCR005C)|FD-Score:3.4|P-value:3.37E-4||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication Gene:CLB1(YGR108W)|FD-Score:4.41|P-value:5.15E-6||SGD DESC:B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome Gene:COX5A(YNL052W)|FD-Score:-4.29|P-value:8.97E-6||SGD DESC:Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication Gene:CTH1(YDR151C)|FD-Score:5.3|P-value:5.66E-8||SGD DESC:Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis Gene:CUE1(YMR264W)|FD-Score:3.89|P-value:4.99E-5||SGD DESC:Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication Gene:DAP2(YHR028C)|FD-Score:4.1|P-value:2.03E-5||SGD DESC:Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p Gene:DCG1(YIR030C)|FD-Score:-3.15|P-value:8.28E-4||SGD DESC:Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain Gene:ECM18(YDR125C)|FD-Score:-3.56|P-value:1.86E-4||SGD DESC:Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication Gene:FAR3(YMR052W)|FD-Score:3.37|P-value:3.80E-4||SGD DESC:Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress Gene:FET4(YMR319C)|FD-Score:3.95|P-value:3.97E-5||SGD DESC:Low-affinity Fe(II) transporter of the plasma membrane Gene:FKH1(YIL131C)|FD-Score:-3.28|P-value:5.27E-4||SGD DESC:Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication Gene:GPM3(YOL056W)|FD-Score:-3.48|P-value:2.46E-4||SGD DESC:Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event Gene:GTR1(YML121W)|FD-Score:6.21|P-value:2.70E-10||SGD DESC:Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB Gene:HIS1(YER055C)|FD-Score:4.2|P-value:1.31E-5||SGD DESC:ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control Gene:HXT14(YNL318C)|FD-Score:3.18|P-value:7.27E-4||SGD DESC:Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:IFM1(YOL023W)|FD-Score:-3.81|P-value:6.97E-5||SGD DESC:Mitochondrial translation initiation factor 2 Gene:IMA5(YJL216C)|FD-Score:-3.58|P-value:1.74E-4||SGD DESC:Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose Gene:IMG1(YCR046C)|FD-Score:-3.66|P-value:1.24E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome Gene:INM2(YDR287W)|FD-Score:3.42|P-value:3.08E-4||SGD DESC:Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy Gene:IOC3(YFR013W)|FD-Score:4.21|P-value:1.30E-5||SGD DESC:Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication Gene:IRC15(YPL017C)|FD-Score:4.4|P-value:5.29E-6||SGD DESC:Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci Gene:ISU2(YOR226C)|FD-Score:3.77|P-value:8.06E-5||SGD DESC:Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved Gene:LEE1(YPL054W)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Zinc-finger protein of unknown function Gene:MET10(YFR030W)|FD-Score:5.87|P-value:2.21E-9||SGD DESC:Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide Gene:MON2(YNL297C)|FD-Score:3.82|P-value:6.54E-5||SGD DESC:Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins Gene:MRPL10(YNL284C)|FD-Score:-3.28|P-value:5.21E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels Gene:NIT3(YLR351C)|FD-Score:3.18|P-value:7.48E-4||SGD DESC:Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member Gene:NMA111(YNL123W)|FD-Score:3.31|P-value:4.69E-4||SGD DESC:Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Gene:NPP2(YEL016C)|FD-Score:3.48|P-value:2.55E-4||SGD DESC:Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication Gene:PDR1(YGL013C)|FD-Score:3.2|P-value:6.97E-4||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PMP2(YEL017C-A)|FD-Score:3.33|P-value:4.40E-4||SGD DESC:Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication Gene:PPQ1(YPL179W)|FD-Score:3.46|P-value:2.73E-4||SGD DESC:Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors Gene:RAV1(YJR033C)|FD-Score:3.14|P-value:8.44E-4||SGD DESC:Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate Gene:RCF1(YML030W)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast Gene:RCN1(YKL159C)|FD-Score:3.31|P-value:4.75E-4||SGD DESC:Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region Gene:RGI2(YIL057C)|FD-Score:-3.25|P-value:5.68E-4||SGD DESC:Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose Gene:ROX1(YPR065W)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance Gene:RSM19(YNR037C)|FD-Score:-3.21|P-value:6.72E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein Gene:RTS3(YGR161C_p)|FD-Score:-3.1|P-value:9.76E-4||SGD DESC:Putative component of the protein phosphatase type 2A complex Gene:SAL1(YNL083W)|FD-Score:3.8|P-value:7.14E-5||SGD DESC:ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains Gene:SMY1(YKL079W)|FD-Score:-3.43|P-value:2.97E-4||SGD DESC:Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins Gene:SSD1(YDR293C)|FD-Score:3.27|P-value:5.42E-4||SGD DESC:Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function Gene:TIM11(YDR322C-A)|FD-Score:3.54|P-value:1.99E-4||SGD DESC:Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase Gene:TMA7(YLR262C-A)|FD-Score:3.89|P-value:4.95E-5||SGD DESC:Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress Gene:TSC3(YBR058C-A)|FD-Score:3.26|P-value:5.60E-4||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:YBR012C(YBR012C_d)|FD-Score:-3.43|P-value:3.03E-4||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p Gene:YDR008C(YDR008C_d)|FD-Score:5.2|P-value:9.87E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR524W-C(YDR524W-C_p)|FD-Score:-3.18|P-value:7.24E-4||SGD DESC:Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin Gene:YER134C(YER134C)|FD-Score:4.81|P-value:7.52E-7||SGD DESC:Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene Gene:YGR250C(YGR250C)|FD-Score:-4.48|P-value:3.78E-6||SGD DESC:Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:YHL008C(YHL008C_p)|FD-Score:3.46|P-value:2.68E-4||SGD DESC:Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YIM1(YMR152W)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:YIR016W(YIR016W_p)|FD-Score:-3.86|P-value:5.61E-5||SGD DESC:Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication Gene:YJL181W(YJL181W_p)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication Gene:YLR279W(YLR279W_d)|FD-Score:4.92|P-value:4.25E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR031W-A(YMR031W-A_d)|FD-Score:5.36|P-value:4.09E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C Gene:YMR084W(YMR084W_p)|FD-Score:5.1|P-value:1.67E-7||SGD DESC:Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 Gene:YND1(YER005W)|FD-Score:3.11|P-value:9.36E-4||SGD DESC:Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity Gene:YNL010W(YNL010W_p)|FD-Score:3.34|P-value:4.22E-4||SGD DESC:Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation Gene:YOL037C(YOL037C_d)|FD-Score:4.46|P-value:4.02E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W Gene:YOL079W(YOL079W_d)|FD-Score:4.88|P-value:5.23E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR072W(YOR072W_d)|FD-Score:3.54|P-value:2.04E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Gene:YPL039W(YPL039W_p)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Putative protein of unknown function; YPL039W is not an essential gene Gene:YPR027C(YPR027C_p)|FD-Score:3.26|P-value:5.63E-4||SGD DESC:Putative protein of unknown function Gene:YPR053C(YPR053C_d)|FD-Score:-3.82|P-value:6.54E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C Gene:YPR197C(YPR197C_d)|FD-Score:-4.17|P-value:1.49E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YTA6(YPL074W)|FD-Score:3.46|P-value:2.69E-4||SGD DESC:Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress Gene:AHA1(YDR214W)|FD-Score:3.48|P-value:2.51E-4||SGD DESC:Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress Gene:AIM4(YBR194W)|FD-Score:3.33|P-value:4.40E-4||SGD DESC:Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress Gene:AKR1(YDR264C)|FD-Score:4.36|P-value:6.63E-6||SGD DESC:Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication Gene:CHA4(YLR098C)|FD-Score:-3.22|P-value:6.34E-4||SGD DESC:DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain Gene:CHS6(YJL099W)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication Gene:CIT2(YCR005C)|FD-Score:3.4|P-value:3.37E-4||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication Gene:CLB1(YGR108W)|FD-Score:4.41|P-value:5.15E-6||SGD DESC:B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome Gene:COX5A(YNL052W)|FD-Score:-4.29|P-value:8.97E-6||SGD DESC:Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication Gene:CTH1(YDR151C)|FD-Score:5.3|P-value:5.66E-8||SGD DESC:Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis Gene:CUE1(YMR264W)|FD-Score:3.89|P-value:4.99E-5||SGD DESC:Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication Gene:DAP2(YHR028C)|FD-Score:4.1|P-value:2.03E-5||SGD DESC:Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p Gene:DCG1(YIR030C)|FD-Score:-3.15|P-value:8.28E-4||SGD DESC:Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain Gene:ECM18(YDR125C)|FD-Score:-3.56|P-value:1.86E-4||SGD DESC:Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication Gene:FAR3(YMR052W)|FD-Score:3.37|P-value:3.80E-4||SGD DESC:Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress Gene:FET4(YMR319C)|FD-Score:3.95|P-value:3.97E-5||SGD DESC:Low-affinity Fe(II) transporter of the plasma membrane Gene:FKH1(YIL131C)|FD-Score:-3.28|P-value:5.27E-4||SGD DESC:Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication Gene:GPM3(YOL056W)|FD-Score:-3.48|P-value:2.46E-4||SGD DESC:Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event Gene:GTR1(YML121W)|FD-Score:6.21|P-value:2.70E-10||SGD DESC:Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB Gene:HIS1(YER055C)|FD-Score:4.2|P-value:1.31E-5||SGD DESC:ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control Gene:HXT14(YNL318C)|FD-Score:3.18|P-value:7.27E-4||SGD DESC:Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:IFM1(YOL023W)|FD-Score:-3.81|P-value:6.97E-5||SGD DESC:Mitochondrial translation initiation factor 2 Gene:IMA5(YJL216C)|FD-Score:-3.58|P-value:1.74E-4||SGD DESC:Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose Gene:IMG1(YCR046C)|FD-Score:-3.66|P-value:1.24E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome Gene:INM2(YDR287W)|FD-Score:3.42|P-value:3.08E-4||SGD DESC:Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy Gene:IOC3(YFR013W)|FD-Score:4.21|P-value:1.30E-5||SGD DESC:Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication Gene:IRC15(YPL017C)|FD-Score:4.4|P-value:5.29E-6||SGD DESC:Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci Gene:ISU2(YOR226C)|FD-Score:3.77|P-value:8.06E-5||SGD DESC:Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved Gene:LEE1(YPL054W)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Zinc-finger protein of unknown function Gene:MET10(YFR030W)|FD-Score:5.87|P-value:2.21E-9||SGD DESC:Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide Gene:MON2(YNL297C)|FD-Score:3.82|P-value:6.54E-5||SGD DESC:Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins Gene:MRPL10(YNL284C)|FD-Score:-3.28|P-value:5.21E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels Gene:NIT3(YLR351C)|FD-Score:3.18|P-value:7.48E-4||SGD DESC:Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member Gene:NMA111(YNL123W)|FD-Score:3.31|P-value:4.69E-4||SGD DESC:Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Gene:NPP2(YEL016C)|FD-Score:3.48|P-value:2.55E-4||SGD DESC:Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication Gene:PDR1(YGL013C)|FD-Score:3.2|P-value:6.97E-4||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PMP2(YEL017C-A)|FD-Score:3.33|P-value:4.40E-4||SGD DESC:Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication Gene:PPQ1(YPL179W)|FD-Score:3.46|P-value:2.73E-4||SGD DESC:Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors Gene:RAV1(YJR033C)|FD-Score:3.14|P-value:8.44E-4||SGD DESC:Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate Gene:RCF1(YML030W)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast Gene:RCN1(YKL159C)|FD-Score:3.31|P-value:4.75E-4||SGD DESC:Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region Gene:RGI2(YIL057C)|FD-Score:-3.25|P-value:5.68E-4||SGD DESC:Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose Gene:ROX1(YPR065W)|FD-Score:4.2|P-value:1.35E-5||SGD DESC:Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance Gene:RSM19(YNR037C)|FD-Score:-3.21|P-value:6.72E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein Gene:RTS3(YGR161C_p)|FD-Score:-3.1|P-value:9.76E-4||SGD DESC:Putative component of the protein phosphatase type 2A complex Gene:SAL1(YNL083W)|FD-Score:3.8|P-value:7.14E-5||SGD DESC:ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains Gene:SMY1(YKL079W)|FD-Score:-3.43|P-value:2.97E-4||SGD DESC:Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins Gene:SSD1(YDR293C)|FD-Score:3.27|P-value:5.42E-4||SGD DESC:Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function Gene:TIM11(YDR322C-A)|FD-Score:3.54|P-value:1.99E-4||SGD DESC:Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase Gene:TMA7(YLR262C-A)|FD-Score:3.89|P-value:4.95E-5||SGD DESC:Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress Gene:TSC3(YBR058C-A)|FD-Score:3.26|P-value:5.60E-4||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:YBR012C(YBR012C_d)|FD-Score:-3.43|P-value:3.03E-4||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p Gene:YDR008C(YDR008C_d)|FD-Score:5.2|P-value:9.87E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR524W-C(YDR524W-C_p)|FD-Score:-3.18|P-value:7.24E-4||SGD DESC:Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin Gene:YER134C(YER134C)|FD-Score:4.81|P-value:7.52E-7||SGD DESC:Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene Gene:YGR250C(YGR250C)|FD-Score:-4.48|P-value:3.78E-6||SGD DESC:Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:YHL008C(YHL008C_p)|FD-Score:3.46|P-value:2.68E-4||SGD DESC:Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YIM1(YMR152W)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:YIR016W(YIR016W_p)|FD-Score:-3.86|P-value:5.61E-5||SGD DESC:Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication Gene:YJL181W(YJL181W_p)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication Gene:YLR279W(YLR279W_d)|FD-Score:4.92|P-value:4.25E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR031W-A(YMR031W-A_d)|FD-Score:5.36|P-value:4.09E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C Gene:YMR084W(YMR084W_p)|FD-Score:5.1|P-value:1.67E-7||SGD DESC:Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 Gene:YND1(YER005W)|FD-Score:3.11|P-value:9.36E-4||SGD DESC:Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity Gene:YNL010W(YNL010W_p)|FD-Score:3.34|P-value:4.22E-4||SGD DESC:Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation Gene:YOL037C(YOL037C_d)|FD-Score:4.46|P-value:4.02E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W Gene:YOL079W(YOL079W_d)|FD-Score:4.88|P-value:5.23E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR072W(YOR072W_d)|FD-Score:3.54|P-value:2.04E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Gene:YPL039W(YPL039W_p)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Putative protein of unknown function; YPL039W is not an essential gene Gene:YPR027C(YPR027C_p)|FD-Score:3.26|P-value:5.63E-4||SGD DESC:Putative protein of unknown function Gene:YPR053C(YPR053C_d)|FD-Score:-3.82|P-value:6.54E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C Gene:YPR197C(YPR197C_d)|FD-Score:-4.17|P-value:1.49E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YTA6(YPL074W)|FD-Score:3.46|P-value:2.69E-4||SGD DESC:Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR076C_d4.885.42E-71.07YLR076C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
YNL308C3.817.02E-50.32KRI1Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p
YNL112W3.492.46E-40.19DBP2ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
YNL178W3.295.00E-40.02RPS3Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
YDR280W3.275.33E-40.01RRP45Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
YMR149W3.275.47E-40.01SWP1Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
YMR239C3.255.76E-40.03RNT1Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes
YDR267C3.226.47E-40.00CIA1Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein
YGR094W3.216.55E-40.04VAS1Mitochondrial and cytoplasmic valyl-tRNA synthetase
YPL043W3.187.48E-40.08NOP4Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
YJL008C3.109.72E-40.02CCT8Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YNL113W3.080.001050.01RPC19RNA polymerase subunit AC19, common to RNA polymerases I and III
YGR048W3.070.001090.05UFD1Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
YMR168C3.020.001270.24CEP3Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
YPR142C_d2.780.002710.02YPR142C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YML121W6.212.70E-10GTR1Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
YFR030W5.872.21E-9MET10Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide
YMR031W-A_d5.364.09E-8YMR031W-A_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
YDR151C5.305.66E-8CTH1Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis
YDR008C_d5.209.87E-8YDR008C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR084W_p5.101.67E-7YMR084W_pPutative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
YLR279W_d4.924.25E-7YLR279W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL079W_d4.885.23E-7YOL079W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER134C4.817.52E-7YER134CMagnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene
YOL037C_d4.464.02E-6YOL037C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W
YGR108W4.415.15E-6CLB1B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YPL017C4.405.29E-6IRC15Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
YDR264C4.366.63E-6AKR1Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication
YFR013W4.211.30E-5IOC3Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication
YER055C4.201.31E-5HIS1ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control

GO enrichment analysis for SGTC_1956
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0977.63E-14SGTC_1700st030840 7.9 μMTimTec (Natural product derivative library)54993070.12766PDR1
0.0881.01E-11SGTC_1603st002045 67.8 μMTimTec (Natural product derivative library)58879850.0512821TSC3-RPN4
0.0871.68E-11SGTC_32369132701 49.5 μMChembridge (Drug-like library)242825240.0777778TSC3-RPN4
0.0863.62E-11SGTC_18584-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 μMTimTec (Natural product derivative library)7563770.125TSC3-RPN4
0.0809.20E-10SGTC_21105483698 200.0 μMChembridge (Fragment library)28487650.038961TSC3-RPN4
0.0791.00E-9SGTC_14740330-0125 5.3 μMChemDiv (Drug-like library)X14740.0714286
0.0781.88E-9SGTC_30749116018 49.5 μMChembridge (Drug-like library)170273030.0555556RNA processing & uracil transport
0.0781.88E-9SGTC_11730443-0020 122.0 μMChemDiv (Drug-like library)53312950.121622TSC3-RPN4
0.0773.07E-9SGTC_5274476-4215 268.0 μMChemDiv (Drug-like library)44187540.0792079PDR1
0.0773.24E-9SGTC_5481436-0017 110.0 μMChemDiv (Drug-like library)96771370.0777778TSC3-RPN4
0.0764.96E-9SGTC_9851493-0307 8.7 μMChemDiv (Drug-like library)32782740.0810811TSC3-RPN4
0.0765.08E-9SGTC_1604st002052 72.4 μMTimTec (Natural product derivative library)62548340.0379747TSC3-RPN4
0.0765.39E-9SGTC_520329-0193 875.0 nMChemDiv (Drug-like library)37392920.0625TSC3-RPN4
0.0765.98E-9SGTC_30259087895 49.5 μMChembridge (Drug-like library)171736410.0537634PDR1
0.0741.16E-8SGTC_505gw-5074 63.9 μMICCB bioactive library59242080.101266

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_1114scopoletin1.73 μM0.3859655280460TimTec (Natural product library)192.168121.64114
SGTC_2544sphondin68.51 μM0.377049108104Microsource (Natural product library)216.189522.18704RNA pol III & RNase P/MRP
SGTC_2410aloe-emodin-8-o-glycoside46.3 μM0.36986314077415TimTec (Pure natural product library)432.3775-0.21610mitochondrial processes
SGTC_15258-methoxypsoralen92.5 μM0.3333334114TimTec (Pure natural product library)216.189522.18704DNA damage response
SGTC_2556citropten84.59 μM0.2786892775Microsource (Natural product library)206.19471.86604
SGTC_1569carminic acid40.6 μM0.27848114749TimTec (Pure natural product library)492.3864-0.436913
SGTC_2490carminic acid95.39 μM0.27848114749TimTec (Pure natural product library)492.3864-0.436913
SGTC_2518prenyletin46.28 μM0.2753623873459Microsource (Natural product library)246.258563.10614
SGTC_1650st01191645.8 μM0.268657242528TimTec (Natural product derivative library)436.496922.93836
SGTC_2543pimpinellin60.67 μM0.2575764825Microsource (Natural product library)246.21552.1705Golgi
SGTC_15346-azauridine81.6 μM0.25233502TimTec (Pure natural product library)245.18944-2.43247RNA pol III & RNase P/MRP