Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YLR076C_d | 4.88 | 5.42E-7 | 1.07 | YLR076C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 |
YNL308C | 3.81 | 7.02E-5 | 0.32 | KRI1 | Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p |
YNL112W | 3.49 | 2.46E-4 | 0.19 | DBP2 | ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites |
YNL178W | 3.29 | 5.00E-4 | 0.02 | RPS3 | Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 |
YDR280W | 3.27 | 5.33E-4 | 0.01 | RRP45 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress |
YMR149W | 3.27 | 5.47E-4 | 0.01 | SWP1 | Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum |
YMR239C | 3.25 | 5.76E-4 | 0.03 | RNT1 | Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes |
YDR267C | 3.22 | 6.47E-4 | 0.00 | CIA1 | Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein |
YGR094W | 3.21 | 6.55E-4 | 0.04 | VAS1 | Mitochondrial and cytoplasmic valyl-tRNA synthetase |
YPL043W | 3.18 | 7.48E-4 | 0.08 | NOP4 | Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) |
YJL008C | 3.10 | 9.72E-4 | 0.02 | CCT8 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YNL113W | 3.08 | 0.00105 | 0.01 | RPC19 | RNA polymerase subunit AC19, common to RNA polymerases I and III |
YGR048W | 3.07 | 0.00109 | 0.05 | UFD1 | Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP) |
YMR168C | 3.02 | 0.00127 | 0.24 | CEP3 | Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain |
YPR142C_d | 2.78 | 0.00271 | 0.02 | YPR142C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing |