Deletion Strain | FD score | P-value | Gene | Gene Description |
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YOR247W | 7.25 | 2.16E-13 | SRL1 | Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication |
YMR072W | 5.82 | 3.02E-9 | ABF2 | Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation |
YJL105W | 5.57 | 1.24E-8 | SET4 | Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication |
YPR120C | 5.43 | 2.85E-8 | CLB5 | B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase |
YEL045C_d | 4.99 | 2.99E-7 | YEL045C_d | Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress |
YBR218C | 4.82 | 7.17E-7 | PYC2 | Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication |
YPL118W | 4.81 | 7.43E-7 | MRP51 | Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences |
YDR158W | 4.64 | 1.74E-6 | HOM2 | Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis |
YML078W | 4.43 | 4.64E-6 | CPR3 | Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria |
YMR021C | 4.38 | 5.88E-6 | MAC1 | Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport |
YBR039W | 4.30 | 8.57E-6 | ATP3 | Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis |
YOL018C | 4.30 | 8.62E-6 | TLG2 | Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) |
YNL177C | 4.18 | 1.44E-5 | MRPL22 | Mitochondrial ribosomal protein of the large subunit |
YKL211C | 4.14 | 1.72E-5 | TRP3 | Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p |
YJR043C | 4.13 | 1.84E-5 | POL32 | Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p |