Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YLR208W | 10.90 | 5.39E-28 | 4.90 | SEC13 | Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress |
YGL238W | 6.01 | 9.50E-10 | 0.06 | CSE1 | Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation |
YDL195W | 5.95 | 1.37E-9 | 0.91 | SEC31 | Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance |
YFL005W | 5.04 | 2.39E-7 | 0.08 | SEC4 | Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane |
YNR011C | 4.95 | 3.64E-7 | 0.22 | PRP2 | RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16 |
YOR250C | 4.74 | 1.09E-6 | 0.01 | CLP1 | Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation |
YNL216W | 4.73 | 1.13E-6 | 0.21 | RAP1 | Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain) |
YOL097C | 4.52 | 3.05E-6 | 0.45 | WRS1 | Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA |
YLR457C | 4.08 | 2.27E-5 | 0.05 | NBP1 | Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication |
YDR353W | 4.03 | 2.84E-5 | 0.26 | TRR1 | Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication |
YBR140C | 3.77 | 8.21E-5 | 0.12 | IRA1 | GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication |
YIR010W | 3.65 | 1.31E-4 | 0.04 | DSN1 | Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation |
YDR526C_d | 3.61 | 1.54E-4 | 0.03 | YDR526C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YDR396W_d | 3.58 | 1.74E-4 | 0.04 | YDR396W_d | Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex |
YOL149W | 3.53 | 2.04E-4 | 0.10 | DCP1 | Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress |