st071811

ethyl 2-amino-4-(2,4-dichlorophenyl)-6-(hydroxymethyl)-8-oxo-4H-pyrano[3,2-b]pyran-3-carboxylate

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_1980
Screen concentration 45.7 μM
Source TimTec (Natural product derivative library)
PubChem CID 4974850
SMILES CCOC(=O)C1=C(OC2=C(C1C3=C(C=C(C=C3)Cl)Cl)OC(=CC2=O)CO)N
Standardized SMILES CCOC(=O)C1=C(N)OC2=C(OC(=CC2=O)CO)C1c3ccc(Cl)cc3Cl
Molecular weight 412.2208
ALogP 1.98
H-bond donor count 2
H-bond acceptor count 7
Response signature RPP1 & pyrimidine depletion

Pool Growth Kinetics
% growth inhibition (Het. pool) 2.78
% growth inhibition (Hom. pool) -2.86


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4974850
Download HIP data (tab-delimited text)  (excel)
Gene:ACT1(YFL039C)|FD-Score:3.12|P-value:9.15E-4|Clearance:0.15||SGD DESC:Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions Gene:AFG2(YLR397C)|FD-Score:3.92|P-value:4.36E-5|Clearance:0.03||SGD DESC:ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; may be involved in degradation of aberrant mRNAs Gene:BCP1(YDR361C)|FD-Score:-4.1|P-value:2.09E-5|Clearance:0||SGD DESC:Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport Gene:CCT5(YJR064W)|FD-Score:-3.29|P-value:4.93E-4|Clearance:0||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:FCP1(YMR277W)|FD-Score:4.24|P-value:1.13E-5|Clearance:0.31||SGD DESC:Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) Gene:GLC7(YER133W)|FD-Score:5.92|P-value:1.64E-9|Clearance:1.68||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:PDI1(YCL043C)|FD-Score:3.51|P-value:2.25E-4|Clearance:0.25||SGD DESC:Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication Gene:PRP5(YBR237W)|FD-Score:3.89|P-value:4.94E-5|Clearance:0.26||SGD DESC:RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA Gene:RSC6(YCR052W)|FD-Score:-3.37|P-value:3.82E-4|Clearance:0||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:SEC63(YOR254C)|FD-Score:3.26|P-value:5.61E-4|Clearance:0.14||SGD DESC:Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:TFC8(YPL007C)|FD-Score:3.63|P-value:1.42E-4|Clearance:0.12||SGD DESC:One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 Gene:ACT1(YFL039C)|FD-Score:3.12|P-value:9.15E-4|Clearance:0.15||SGD DESC:Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions Gene:AFG2(YLR397C)|FD-Score:3.92|P-value:4.36E-5|Clearance:0.03||SGD DESC:ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; may be involved in degradation of aberrant mRNAs Gene:BCP1(YDR361C)|FD-Score:-4.1|P-value:2.09E-5|Clearance:0||SGD DESC:Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport Gene:CCT5(YJR064W)|FD-Score:-3.29|P-value:4.93E-4|Clearance:0||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:FCP1(YMR277W)|FD-Score:4.24|P-value:1.13E-5|Clearance:0.31||SGD DESC:Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) Gene:GLC7(YER133W)|FD-Score:5.92|P-value:1.64E-9|Clearance:1.68||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:PDI1(YCL043C)|FD-Score:3.51|P-value:2.25E-4|Clearance:0.25||SGD DESC:Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication Gene:PRP5(YBR237W)|FD-Score:3.89|P-value:4.94E-5|Clearance:0.26||SGD DESC:RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA Gene:RSC6(YCR052W)|FD-Score:-3.37|P-value:3.82E-4|Clearance:0||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:SEC63(YOR254C)|FD-Score:3.26|P-value:5.61E-4|Clearance:0.14||SGD DESC:Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:TFC8(YPL007C)|FD-Score:3.63|P-value:1.42E-4|Clearance:0.12||SGD DESC:One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4974850
Download HOP data (tab-delimited text)  (excel)
Gene:ANP1(YEL036C)|FD-Score:3.16|P-value:7.98E-4||SGD DESC:Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol Gene:ARO3(YDR035W)|FD-Score:-3.77|P-value:8.17E-5||SGD DESC:3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan Gene:ARP6(YLR085C)|FD-Score:-3.17|P-value:7.67E-4||SGD DESC:Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:ARR3(YPR201W)|FD-Score:3.17|P-value:7.67E-4||SGD DESC:Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite Gene:ATP4(YPL078C)|FD-Score:3.48|P-value:2.47E-4||SGD DESC:Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated Gene:BEM3(YPL115C)|FD-Score:4.32|P-value:7.87E-6||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly Gene:BFA1(YJR053W)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis Gene:CDC26(YFR036W)|FD-Score:3.83|P-value:6.34E-5||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Gene:CLB5(YPR120C)|FD-Score:3.23|P-value:6.24E-4||SGD DESC:B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase Gene:CPR1(YDR155C)|FD-Score:3.11|P-value:9.48E-4||SGD DESC:Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress Gene:CWC27(YPL064C)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress Gene:CYS3(YAL012W)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress Gene:DID4(YKL002W)|FD-Score:3.82|P-value:6.71E-5||SGD DESC:Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis Gene:DLD2(YDL178W)|FD-Score:-3.6|P-value:1.59E-4||SGD DESC:D-lactate dehydrogenase, located in the mitochondrial matrix Gene:FET4(YMR319C)|FD-Score:5.28|P-value:6.60E-8||SGD DESC:Low-affinity Fe(II) transporter of the plasma membrane Gene:GIM5(YML094W)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:GSF2(YML048W)|FD-Score:3.71|P-value:1.04E-4||SGD DESC:ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression Gene:HAP2(YGL237C)|FD-Score:-3.47|P-value:2.57E-4||SGD DESC:Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding Gene:HXT2(YMR011W)|FD-Score:3.87|P-value:5.35E-5||SGD DESC:High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose Gene:ICL2(YPR006C)|FD-Score:3.59|P-value:1.68E-4||SGD DESC:2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol Gene:LSC2(YGR244C)|FD-Score:3.79|P-value:7.62E-5||SGD DESC:Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate Gene:MAK32(YCR019W)|FD-Score:4.17|P-value:1.55E-5||SGD DESC:Protein necessary for structural stability of L-A double-stranded RNA-containing particles Gene:MNT4(YNR059W)|FD-Score:3.26|P-value:5.53E-4||SGD DESC:Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation Gene:OXR1(YPL196W)|FD-Score:3.75|P-value:8.91E-5||SGD DESC:Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes Gene:PCL1(YNL289W)|FD-Score:4.11|P-value:1.94E-5||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth Gene:PDR15(YDR406W)|FD-Score:3.52|P-value:2.16E-4||SGD DESC:Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element Gene:RAD16(YBR114W)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex Gene:RGP1(YDR137W)|FD-Score:3.6|P-value:1.59E-4||SGD DESC:Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p Gene:RPL6B(YLR448W)|FD-Score:5.03|P-value:2.41E-7||SGD DESC:Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication Gene:RPS1A(YLR441C)|FD-Score:-3.17|P-value:7.72E-4||SGD DESC:Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication Gene:RSM28(YDR494W)|FD-Score:-3.75|P-value:8.77E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation Gene:SAM37(YMR060C)|FD-Score:4.06|P-value:2.47E-5||SGD DESC:Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability Gene:SEA4(YBL104C)|FD-Score:4.3|P-value:8.40E-6||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites Gene:SHU2(YDR078C)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function Gene:SLO1(YER180C-A)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO Gene:SPP1(YPL138C)|FD-Score:5.35|P-value:4.36E-8||SGD DESC:Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein Gene:SRB5(YGR104C)|FD-Score:3.53|P-value:2.10E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance Gene:SYS1(YJL004C)|FD-Score:-3.96|P-value:3.82E-5||SGD DESC:Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation Gene:TNA1(YGR260W)|FD-Score:4.01|P-value:2.98E-5||SGD DESC:High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) Gene:VAM10(YOR068C)|FD-Score:-3.1|P-value:9.64E-4||SGD DESC:Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering Gene:VBA4(YDR119W_p)|FD-Score:4.74|P-value:1.07E-6||SGD DESC:Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene Gene:VPS63(YLR261C_d)|FD-Score:5.91|P-value:1.73E-9||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Gene:VPS72(YDR485C)|FD-Score:3.17|P-value:7.53E-4||SGD DESC:Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:WSC2(YNL283C)|FD-Score:3.79|P-value:7.52E-5||SGD DESC:Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response Gene:YAL065C(YAL065C_p)|FD-Score:3.74|P-value:9.38E-5||SGD DESC:Putative protein of unknown function; has homology to FLO1; possible pseudogene Gene:YAR035C-A(YAR035C-A_p)|FD-Score:6.37|P-value:9.55E-11||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis Gene:YBR296C-A(YBR296C-A_p)|FD-Score:4.88|P-value:5.29E-7||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YDR015C(YDR015C_d)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A Gene:YDR379C-A(YDR379C-A)|FD-Score:3.81|P-value:6.94E-5||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy Gene:YEL043W(YEL043W)|FD-Score:3.6|P-value:1.62E-4||SGD DESC:Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold Gene:YFL032W(YFL032W_d)|FD-Score:-4.6|P-value:2.14E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene Gene:YFR056C(YFR056C_d)|FD-Score:4.89|P-value:4.96E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W Gene:YKR032W(YKR032W_d)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL024C(YNL024C_p)|FD-Score:-3.22|P-value:6.44E-4||SGD DESC:Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern Gene:YPS5(YGL259W_p)|FD-Score:4.38|P-value:5.92E-6||SGD DESC:Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p Gene:ANP1(YEL036C)|FD-Score:3.16|P-value:7.98E-4||SGD DESC:Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol Gene:ARO3(YDR035W)|FD-Score:-3.77|P-value:8.17E-5||SGD DESC:3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan Gene:ARP6(YLR085C)|FD-Score:-3.17|P-value:7.67E-4||SGD DESC:Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:ARR3(YPR201W)|FD-Score:3.17|P-value:7.67E-4||SGD DESC:Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite Gene:ATP4(YPL078C)|FD-Score:3.48|P-value:2.47E-4||SGD DESC:Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated Gene:BEM3(YPL115C)|FD-Score:4.32|P-value:7.87E-6||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly Gene:BFA1(YJR053W)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis Gene:CDC26(YFR036W)|FD-Score:3.83|P-value:6.34E-5||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Gene:CLB5(YPR120C)|FD-Score:3.23|P-value:6.24E-4||SGD DESC:B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase Gene:CPR1(YDR155C)|FD-Score:3.11|P-value:9.48E-4||SGD DESC:Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress Gene:CWC27(YPL064C)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress Gene:CYS3(YAL012W)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress Gene:DID4(YKL002W)|FD-Score:3.82|P-value:6.71E-5||SGD DESC:Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis Gene:DLD2(YDL178W)|FD-Score:-3.6|P-value:1.59E-4||SGD DESC:D-lactate dehydrogenase, located in the mitochondrial matrix Gene:FET4(YMR319C)|FD-Score:5.28|P-value:6.60E-8||SGD DESC:Low-affinity Fe(II) transporter of the plasma membrane Gene:GIM5(YML094W)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Gene:GSF2(YML048W)|FD-Score:3.71|P-value:1.04E-4||SGD DESC:ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression Gene:HAP2(YGL237C)|FD-Score:-3.47|P-value:2.57E-4||SGD DESC:Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding Gene:HXT2(YMR011W)|FD-Score:3.87|P-value:5.35E-5||SGD DESC:High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose Gene:ICL2(YPR006C)|FD-Score:3.59|P-value:1.68E-4||SGD DESC:2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol Gene:LSC2(YGR244C)|FD-Score:3.79|P-value:7.62E-5||SGD DESC:Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate Gene:MAK32(YCR019W)|FD-Score:4.17|P-value:1.55E-5||SGD DESC:Protein necessary for structural stability of L-A double-stranded RNA-containing particles Gene:MNT4(YNR059W)|FD-Score:3.26|P-value:5.53E-4||SGD DESC:Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation Gene:OXR1(YPL196W)|FD-Score:3.75|P-value:8.91E-5||SGD DESC:Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes Gene:PCL1(YNL289W)|FD-Score:4.11|P-value:1.94E-5||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth Gene:PDR15(YDR406W)|FD-Score:3.52|P-value:2.16E-4||SGD DESC:Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element Gene:RAD16(YBR114W)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex Gene:RGP1(YDR137W)|FD-Score:3.6|P-value:1.59E-4||SGD DESC:Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p Gene:RPL6B(YLR448W)|FD-Score:5.03|P-value:2.41E-7||SGD DESC:Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication Gene:RPS1A(YLR441C)|FD-Score:-3.17|P-value:7.72E-4||SGD DESC:Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication Gene:RSM28(YDR494W)|FD-Score:-3.75|P-value:8.77E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation Gene:SAM37(YMR060C)|FD-Score:4.06|P-value:2.47E-5||SGD DESC:Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability Gene:SEA4(YBL104C)|FD-Score:4.3|P-value:8.40E-6||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites Gene:SHU2(YDR078C)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function Gene:SLO1(YER180C-A)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO Gene:SPP1(YPL138C)|FD-Score:5.35|P-value:4.36E-8||SGD DESC:Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein Gene:SRB5(YGR104C)|FD-Score:3.53|P-value:2.10E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance Gene:SYS1(YJL004C)|FD-Score:-3.96|P-value:3.82E-5||SGD DESC:Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation Gene:TNA1(YGR260W)|FD-Score:4.01|P-value:2.98E-5||SGD DESC:High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) Gene:VAM10(YOR068C)|FD-Score:-3.1|P-value:9.64E-4||SGD DESC:Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering Gene:VBA4(YDR119W_p)|FD-Score:4.74|P-value:1.07E-6||SGD DESC:Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene Gene:VPS63(YLR261C_d)|FD-Score:5.91|P-value:1.73E-9||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Gene:VPS72(YDR485C)|FD-Score:3.17|P-value:7.53E-4||SGD DESC:Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:WSC2(YNL283C)|FD-Score:3.79|P-value:7.52E-5||SGD DESC:Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response Gene:YAL065C(YAL065C_p)|FD-Score:3.74|P-value:9.38E-5||SGD DESC:Putative protein of unknown function; has homology to FLO1; possible pseudogene Gene:YAR035C-A(YAR035C-A_p)|FD-Score:6.37|P-value:9.55E-11||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis Gene:YBR296C-A(YBR296C-A_p)|FD-Score:4.88|P-value:5.29E-7||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YDR015C(YDR015C_d)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A Gene:YDR379C-A(YDR379C-A)|FD-Score:3.81|P-value:6.94E-5||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy Gene:YEL043W(YEL043W)|FD-Score:3.6|P-value:1.62E-4||SGD DESC:Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold Gene:YFL032W(YFL032W_d)|FD-Score:-4.6|P-value:2.14E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene Gene:YFR056C(YFR056C_d)|FD-Score:4.89|P-value:4.96E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W Gene:YKR032W(YKR032W_d)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL024C(YNL024C_p)|FD-Score:-3.22|P-value:6.44E-4||SGD DESC:Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern Gene:YPS5(YGL259W_p)|FD-Score:4.38|P-value:5.92E-6||SGD DESC:Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YER133W5.921.64E-91.68GLC7Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
YMR277W4.241.13E-50.32FCP1Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
YLR397C3.924.36E-50.03AFG2ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; may be involved in degradation of aberrant mRNAs
YBR237W3.894.94E-50.26PRP5RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
YPL007C3.631.42E-40.12TFC8One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90
YCL043C3.512.25E-40.25PDI1Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication
YOR254C3.265.61E-40.14SEC63Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YFL039C3.129.15E-40.15ACT1Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YKL125W2.970.001510.01RRN3Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo
YLR076C_d2.960.001550.05YLR076C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
YNL118C2.910.001800.02DCP2Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress
YBR252W2.890.001900.02DUT1deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate
YKL153W_d2.870.002040.10YKL153W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YNL207W2.770.002790.08RIO2Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
YMR268C2.700.003500.06PRP24Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YAR035C-A_p6.379.55E-11YAR035C-A_pPutative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis
YLR261C_d5.911.73E-9VPS63_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
YPL138C5.354.36E-8SPP1Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein
YMR319C5.286.60E-8FET4Low-affinity Fe(II) transporter of the plasma membrane
YLR448W5.032.41E-7RPL6BRibosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication
YFR056C_d4.894.96E-7YFR056C_dDubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YBR296C-A_p4.885.29E-7YBR296C-A_pPutative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR119W_p4.741.07E-6VBA4_pProtein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene
YGL259W_p4.385.92E-6YPS5_pProtein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p
YPL115C4.327.87E-6BEM3Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
YBL104C4.308.40E-6SEA4Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites
YCR019W4.171.55E-5MAK32Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YNL289W4.111.94E-5PCL1Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth
YMR060C4.062.47E-5SAM37Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability
YGR260W4.012.98E-5TNA1High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)

GO enrichment analysis for SGTC_1980
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1119.60E-18SGTC_1979st071809 45.3 μMTimTec (Natural product derivative library)49763330.833333RPP1 & pyrimidine depletion
0.0815.76E-10SGTC_30899117425 49.5 μMChembridge (Drug-like library)94016570.130952
0.0741.30E-8SGTC_2489cantharidin 73.4 μMICCB bioactive library25450.1cell wall signaling
0.0723.58E-8SGTC_1625st003711 30.1 μMTimTec (Natural product derivative library)242070340.0934579calcium & mitochondrial duress
0.0706.71E-8SGTC_1796st049173 110.4 μMTimTec (Natural product derivative library)941340.111111
0.0706.79E-8SGTC_1067clotrimazole 1.4 μMNIH Clinical Collection28120.0731707azole & statin
0.0672.87E-7SGTC_32299132204 49.5 μMChembridge (Drug-like library)176829240.0792079
0.0673.20E-7SGTC_2415hr heat shock (37°C) + cantharidin 155.4 μMICCB bioactive library25450.1cell wall signaling
0.0664.36E-7SGTC_2558carylophyllene oxide 100.0 μMMicrosource (Natural product library)67086940.0481928
0.0664.69E-7SGTC_11841269-1718 139.0 μMChemDiv (Drug-like library)54038210.0930233
0.0655.33E-7SGTC_1621st003705 32.4 μMTimTec (Natural product derivative library)242070320.0970874calcium & mitochondrial duress
0.0631.34E-6SGTC_390986-0283 58.3 μMChemDiv (Drug-like library)31106000.0795455calcium & mitochondrial duress
0.0621.91E-6SGTC_2743auranofin 4.3 μMMiscellaneous166676690.116279RPP1 & pyrimidine depletion
0.0603.41E-6SGTC_11534055-0057 267.0 μMChemDiv (Drug-like library)8827060.1875
0.0595.23E-6SGTC_2619obliquin 87.9 μMMicrosource (Natural product library)67085930.119048cell wall

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1979st07180945.3 μM0.8333334976333TimTec (Natural product derivative library)398.194221.63127RPP1 & pyrimidine depletion
SGTC_1983st07181346.9 μM0.79365111838595TimTec (Natural product derivative library)426.247382.35827RPP1 & pyrimidine depletion
SGTC_1989st07186850.2 μM0.7187516414057TimTec (Natural product derivative library)398.194221.63127
SGTC_1986st07181245 μM0.57746511838594TimTec (Natural product derivative library)426.247382.35827
SGTC_1988st07187253.4 μM0.53424716414116TimTec (Natural product derivative library)374.301660.19729
SGTC_1981st07182647 μM0.5211838600TimTec (Natural product derivative library)425.355231.971210
SGTC_1917st06650728.5 μM0.43156428TimTec (Natural product derivative library)399.3443063.33218Golgi
SGTC_2415st07733357.7 μM0.3947372766255TimTec (Natural product derivative library)346.336161.23426
SGTC_2740felodipine17.08 μM0.3026323333Miscellaneous384.253763.54915
SGTC_2918797717122.06 μM0.2933332236483Chembridge (Drug-like library)305.756143.84824