4063-0024

4-chloro-N-(4-ethoxyphenyl)benzenesulfonamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_199
Screen concentration 41.6 μM
Source ChemDiv (Drug-like library)
PubChem CID 306215
SMILES CCOC1=CC=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)Cl
Standardized SMILES CCOc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1
Molecular weight 311.7839
ALogP 3.31
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 23.47
% growth inhibition (Hom. pool) 6.92


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 306215
Download HIP data (tab-delimited text)  (excel)
Gene:FAS1(YKL182W)|FD-Score:-3.48|P-value:2.48E-4|Clearance:0||SGD DESC:Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities Gene:UTP22(YGR090W)|FD-Score:3.11|P-value:9.51E-4|Clearance:0.22||SGD DESC:Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals Gene:YMR290W-A(YMR290W-A_d)|FD-Score:3.86|P-value:5.61E-5|Clearance:0.76||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase Gene:FAS1(YKL182W)|FD-Score:-3.48|P-value:2.48E-4|Clearance:0||SGD DESC:Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities Gene:UTP22(YGR090W)|FD-Score:3.11|P-value:9.51E-4|Clearance:0.22||SGD DESC:Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals Gene:YMR290W-A(YMR290W-A_d)|FD-Score:3.86|P-value:5.61E-5|Clearance:0.76||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 306215
Download HOP data (tab-delimited text)  (excel)
Gene:ARR2(YPR200C)|FD-Score:3.38|P-value:3.69E-4||SGD DESC:Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p Gene:BUB2(YMR055C)|FD-Score:4.38|P-value:6.01E-6||SGD DESC:Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage Gene:CPS1(YJL172W)|FD-Score:-4.6|P-value:2.08E-6||SGD DESC:Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions Gene:DIA1(YMR316W)|FD-Score:3.29|P-value:5.05E-4||SGD DESC:Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:FLO1(YAR050W)|FD-Score:-3.26|P-value:5.48E-4||SGD DESC:Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p Gene:GIS2(YNL255C)|FD-Score:3.27|P-value:5.30E-4||SGD DESC:Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2 Gene:HRT3(YLR097C)|FD-Score:3.15|P-value:8.09E-4||SGD DESC:Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies Gene:HUT1(YPL244C)|FD-Score:3.5|P-value:2.35E-4||SGD DESC:Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 Gene:HXT14(YNL318C)|FD-Score:4|P-value:3.15E-5||SGD DESC:Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:PAD1(YDR538W)|FD-Score:4.33|P-value:7.54E-6||SGD DESC:Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX Gene:PEX17(YNL214W)|FD-Score:3.25|P-value:5.69E-4||SGD DESC:Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis Gene:PKR1(YMR123W)|FD-Score:3.11|P-value:9.36E-4||SGD DESC:V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress Gene:PSP2(YML017W)|FD-Score:3.23|P-value:6.18E-4||SGD DESC:Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing Gene:PTK1(YKL198C)|FD-Score:3.13|P-value:8.69E-4||SGD DESC:Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein Gene:PUS4(YNL292W)|FD-Score:3.38|P-value:3.56E-4||SGD DESC:Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) Gene:QDR1(YIL120W)|FD-Score:4.19|P-value:1.39E-5||SGD DESC:Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication Gene:SRN2(YLR119W)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus Gene:TRM12(YML005W)|FD-Score:-4.24|P-value:1.13E-5||SGD DESC:S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA Gene:YAL067W-A(YAL067W-A_p)|FD-Score:4.92|P-value:4.28E-7||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YCL001W-B(YCL001W-B_p)|FD-Score:-4.05|P-value:2.52E-5||SGD DESC:Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication Gene:YGL242C(YGL242C_p)|FD-Score:-3.6|P-value:1.61E-4||SGD DESC:Putative protein of unknown function; deletion mutant is viable Gene:YIL029C(YIL029C_p)|FD-Score:3.47|P-value:2.56E-4||SGD DESC:Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W Gene:YJL049W(YJL049W_p)|FD-Score:3.52|P-value:2.12E-4||SGD DESC:Putative protein of unknown function; YJL049W is a non-essential gene Gene:YKR051W(YKR051W_p)|FD-Score:3.52|P-value:2.17E-4||SGD DESC:Putative protein of unknown function Gene:YLR030W(YLR030W_p)|FD-Score:3.91|P-value:4.55E-5||SGD DESC:Putative protein of unknown function Gene:YMR295C(YMR295C)|FD-Score:3.22|P-value:6.43E-4||SGD DESC:Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YOR263C(YOR263C_d)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W Gene:YPR027C(YPR027C_p)|FD-Score:-3.1|P-value:9.81E-4||SGD DESC:Putative protein of unknown function Gene:ARR2(YPR200C)|FD-Score:3.38|P-value:3.69E-4||SGD DESC:Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p Gene:BUB2(YMR055C)|FD-Score:4.38|P-value:6.01E-6||SGD DESC:Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage Gene:CPS1(YJL172W)|FD-Score:-4.6|P-value:2.08E-6||SGD DESC:Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions Gene:DIA1(YMR316W)|FD-Score:3.29|P-value:5.05E-4||SGD DESC:Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:FLO1(YAR050W)|FD-Score:-3.26|P-value:5.48E-4||SGD DESC:Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p Gene:GIS2(YNL255C)|FD-Score:3.27|P-value:5.30E-4||SGD DESC:Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2 Gene:HRT3(YLR097C)|FD-Score:3.15|P-value:8.09E-4||SGD DESC:Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies Gene:HUT1(YPL244C)|FD-Score:3.5|P-value:2.35E-4||SGD DESC:Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 Gene:HXT14(YNL318C)|FD-Score:4|P-value:3.15E-5||SGD DESC:Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:PAD1(YDR538W)|FD-Score:4.33|P-value:7.54E-6||SGD DESC:Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX Gene:PEX17(YNL214W)|FD-Score:3.25|P-value:5.69E-4||SGD DESC:Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis Gene:PKR1(YMR123W)|FD-Score:3.11|P-value:9.36E-4||SGD DESC:V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress Gene:PSP2(YML017W)|FD-Score:3.23|P-value:6.18E-4||SGD DESC:Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing Gene:PTK1(YKL198C)|FD-Score:3.13|P-value:8.69E-4||SGD DESC:Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein Gene:PUS4(YNL292W)|FD-Score:3.38|P-value:3.56E-4||SGD DESC:Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) Gene:QDR1(YIL120W)|FD-Score:4.19|P-value:1.39E-5||SGD DESC:Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication Gene:SRN2(YLR119W)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus Gene:TRM12(YML005W)|FD-Score:-4.24|P-value:1.13E-5||SGD DESC:S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA Gene:YAL067W-A(YAL067W-A_p)|FD-Score:4.92|P-value:4.28E-7||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YCL001W-B(YCL001W-B_p)|FD-Score:-4.05|P-value:2.52E-5||SGD DESC:Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication Gene:YGL242C(YGL242C_p)|FD-Score:-3.6|P-value:1.61E-4||SGD DESC:Putative protein of unknown function; deletion mutant is viable Gene:YIL029C(YIL029C_p)|FD-Score:3.47|P-value:2.56E-4||SGD DESC:Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W Gene:YJL049W(YJL049W_p)|FD-Score:3.52|P-value:2.12E-4||SGD DESC:Putative protein of unknown function; YJL049W is a non-essential gene Gene:YKR051W(YKR051W_p)|FD-Score:3.52|P-value:2.17E-4||SGD DESC:Putative protein of unknown function Gene:YLR030W(YLR030W_p)|FD-Score:3.91|P-value:4.55E-5||SGD DESC:Putative protein of unknown function Gene:YMR295C(YMR295C)|FD-Score:3.22|P-value:6.43E-4||SGD DESC:Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YOR263C(YOR263C_d)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W Gene:YPR027C(YPR027C_p)|FD-Score:-3.1|P-value:9.81E-4||SGD DESC:Putative protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YMR290W-A_d3.865.61E-50.76YMR290W-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YGR090W3.119.51E-40.22UTP22Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals
YPR162C2.890.001950.07ORC4Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
YKL060C2.810.002460.15FBA1Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YIR015W2.670.003850.03RPR2Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress
YIL078W2.640.004150.06THS1Threonyl-tRNA synthetase, essential cytoplasmic protein
YDR086C2.580.004900.09SSS1Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
YML043C2.500.006270.18RRN11Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
YKL059C2.320.010200.10MPE1Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif
YHR074W2.220.013300.02QNS1Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
YPL233W2.190.014100.01NSL1Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YKR038C2.190.014400.00KAE1Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription
YCR012W2.180.014500.02PGK13-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YDL207W2.170.015200.03GLE1Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
YNL006W2.130.016500.01LST8Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YAL067W-A_p4.924.28E-7YAL067W-A_pPutative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YMR055C4.386.01E-6BUB2Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage
YDR538W4.337.54E-6PAD1Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX
YIL120W4.191.39E-5QDR1Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication
YNL318C4.003.15E-5HXT14Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR030W_p3.914.55E-5YLR030W_pPutative protein of unknown function
YOR263C_d3.681.17E-4YOR263C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W
YJL049W_p3.522.12E-4YJL049W_pPutative protein of unknown function; YJL049W is a non-essential gene
YKR051W_p3.522.17E-4YKR051W_pPutative protein of unknown function
YPL244C3.502.35E-4HUT1Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
YIL029C_p3.472.56E-4YIL029C_pPutative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W
YNL292W3.383.56E-4PUS4Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
YPR200C3.383.69E-4ARR2Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p
YLR119W3.354.08E-4SRN2Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
YMR316W3.295.05E-4DIA1Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

GO enrichment analysis for SGTC_199
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0863.12E-11SGTC_1576erythromycin ethylsuccinate 23.2 μMTimTec (Pure natural product library)32560.0614035
0.0791.14E-9SGTC_1903970-0790 3.7 μMChemDiv (Drug-like library)28323520.0655738
0.0715.65E-8SGTC_1983454-2873 16.2 μMChemDiv (Drug-like library)7109570.17241460S ribosome export
0.0691.09E-7SGTC_1730st033808 45.1 μMTimTec (Natural product derivative library)10451660.115385
0.0681.56E-7SGTC_12011889-3372 45.9 μMChemDiv (Drug-like library)53921990.177419Golgi
0.0654.77E-7SGTC_1169aniline yellow 25.8 μMChemDiv (Drug-like library)60510.0625
0.0654.88E-7SGTC_2727riluzole 51.8 μMMiscellaneous50700.103448mitochondrial processes
0.0654.99E-7SGTC_20765212012 200.0 μMChembridge (Fragment library)6048020.0483871
0.0647.95E-7SGTC_2550chrysin dimethyl ether 71.9 μMMicrosource (Natural product library)888810.111111
0.0631.17E-6SGTC_2515chrysin 20.8 μMMicrosource (Natural product library)52816070.0645161RPP1 & pyrimidine depletion
0.0631.29E-6SGTC_32759138069 49.5 μMChembridge (Drug-like library)176170070.203704
0.0622.06E-6SGTC_15081080-0625 72.9 μMChemDiv (Drug-like library)7671110.114754
0.0571.06E-5SGTC_20615245884 81.0 μMChembridge (Fragment library)5738630.0862069tubulin folding & SWR complex
0.0561.81E-5SGTC_185k048-0037 25.5 μMChemDiv (Drug-like library)68275890.0724638RSC & ERG11
0.0552.60E-5SGTC_1574spiramycin 23.7 μMTimTec (Pure natural product library)64198980.0504202

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3346915825443.58 μM0.70731717639500Chembridge (Drug-like library)311.783863.31414
SGTC_2917797910353.79 μM0.6363642980565Chembridge (Drug-like library)327.783263.07225
SGTC_2920798290415.77 μM0.6363646456808Chembridge (Drug-like library)329.7743233.51915
SGTC_3272913741349.47 μM0.48888917614870Chembridge (Drug-like library)321.391362.6415
SGTC_5414513-132194 μM0.477273747515ChemDiv (Drug-like library)305.391963.51314
SGTC_13251431-0015227 μM0.476191103340ChemDiv (Drug-like library)352.620824.06824Golgi
SGTC_11901486-133213 μM0.4736844150046ChemDiv (Drug-like library)487.955885.14325
SGTC_9501165-050894.1 μM0.4680856148369ChemDiv (Drug-like library)303.376082.59214
SGTC_14314049-02609.09 μM0.4313733854841ChemDiv (Drug-like library)412.29033.93315
SGTC_1737st03555769.7 μM0.4166675716916TimTec (Natural product derivative library)286.75284.69802