Deletion Strain | FD score | P-value | Gene | Gene Description |
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YHR043C | 6.23 | 2.39E-10 | DOG2 | 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, paralogous to DOG1, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed |
YFR040W | 5.92 | 1.59E-9 | SAP155 | Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress |
YOL051W | 5.59 | 1.16E-8 | GAL11 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator |
YKR036C | 5.13 | 1.43E-7 | CAF4 | WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication |
YER007C-A | 4.99 | 2.99E-7 | TMA20 | Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress |
YPR145W | 4.97 | 3.39E-7 | ASN1 | Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication |
YMR263W | 4.32 | 7.90E-6 | SAP30 | Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance |
YGR164W_d | 4.32 | 7.98E-6 | YGR164W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YML041C | 4.23 | 1.16E-5 | VPS71 | Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting |
YGL041C_d | 4.16 | 1.60E-5 | YGL041C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YGR124W | 4.13 | 1.81E-5 | ASN2 | Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication |
YMR087W | 4.08 | 2.22E-5 | YMR087W | Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain |
YGL005C | 4.05 | 2.56E-5 | COG7 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
YJL217W | 4.03 | 2.73E-5 | REE1 | Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle |
YLR342W | 4.03 | 2.74E-5 | FKS1 | Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling |