Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDR064W | 5.63 | 8.99E-9 | 1.07 | RPS13 | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15 |
YOR157C | 4.66 | 1.58E-6 | 1.07 | PUP1 | Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z |
YNL149C | 3.59 | 1.66E-4 | 0.27 | PGA2 | Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect |
YOR074C | 3.32 | 4.56E-4 | 0.08 | CDC21 | Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S |
YIL142W | 3.23 | 6.13E-4 | 0.15 | CCT2 | Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YFL017C | 3.09 | 0.00102 | 0.14 | GNA1 | Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA |
YHL015W | 2.95 | 0.00161 | 0.04 | RPS20 | Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10 |
YOL130W | 2.90 | 0.00184 | 3.14E-4 | ALR1 | Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions |
YKL196C | 2.90 | 0.00184 | 0.04 | YKT6 | Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus |
YDR166C | 2.87 | 0.00206 | 0.02 | SEC5 | Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip |
YLR275W | 2.85 | 0.00219 | 0.15 | SMD2 | Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 |
YLR215C | 2.70 | 0.00344 | 0.09 | CDC123 | Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein |
YBL105C | 2.61 | 0.00455 | 1.66E-4 | PKC1 | Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) |
YDR464W | 2.61 | 0.00455 | 0.02 | SPP41 | Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 |
YLR078C | 2.59 | 0.00480 | 0.01 | BOS1 | v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi |