Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBR269C_p | 7.49 | 3.52E-14 | FMP21_p | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YLR404W | 5.05 | 2.25E-7 | FLD1 | Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy |
YDR392W | 4.79 | 8.28E-7 | SPT3 | Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters |
YHL017W_p | 4.48 | 3.78E-6 | YHL017W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication |
YDR337W | 4.33 | 7.60E-6 | MRPS28 | Mitochondrial ribosomal protein of the small subunit |
YJR005W | 4.32 | 7.91E-6 | APL1 | Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex |
YNL145W | 4.13 | 1.83E-5 | MFA2 | Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1 |
YNL127W | 4.05 | 2.56E-5 | FAR11 | Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 |
YBR095C | 3.91 | 4.65E-5 | RXT2 | Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth |
YFL048C | 3.89 | 5.02E-5 | EMP47 | Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport |
YGR089W | 3.73 | 9.76E-5 | NNF2 | Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation |
YDR006C | 3.65 | 1.30E-4 | SOK1 | Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 |
YBL079W | 3.65 | 1.32E-4 | NUP170 | Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication |
YML002W_p | 3.60 | 1.56E-4 | YML002W_p | Putative protein of unknown function; expression induced by heat and by calcium shortage |
YIL107C | 3.49 | 2.46E-4 | PFK26 | 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A |