Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR011W | 29.60 | 5.75E-193 | SNQ2 | Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species |
YKR052C | 6.02 | 8.76E-10 | MRS4 | Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication |
YJR033C | 5.32 | 5.19E-8 | RAV1 | Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate |
YDR010C_d | 4.78 | 8.88E-7 | YDR010C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YIL162W | 3.90 | 4.74E-5 | SUC2 | Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively |
YBR130C | 3.83 | 6.28E-5 | SHE3 | Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance |
YBR139W | 3.76 | 8.58E-5 | YBR139W | Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner |
YAL029C | 3.70 | 1.07E-4 | MYO4 | Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication |
YLR148W | 3.69 | 1.13E-4 | PEP3 | Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis |
YDR072C | 3.68 | 1.16E-4 | IPT1 | Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin |
YLR410W | 3.66 | 1.26E-4 | VIP1 | Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1 |
YOL163W_p | 3.54 | 2.00E-4 | YOL163W_p | Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family |
YPR197C_d | 3.53 | 2.06E-4 | YPR197C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YDL160C | 3.50 | 2.35E-4 | DHH1 | Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress |
YHR014W | 3.50 | 2.36E-4 | SPO13 | Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II |