Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR032C | 51.10 | 0 | PST2 | Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication |
YGR291C_d | 6.75 | 7.18E-12 | YGR291C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YNL034W_p | 6.07 | 6.39E-10 | YNL034W_p | Putative protein of unknown function; YNL034W is not an essential gene |
YJL124C | 5.95 | 1.37E-9 | LSM1 | Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress |
YKR072C | 5.93 | 1.54E-9 | SIS2 | Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis |
YPL039W_p | 5.48 | 2.16E-8 | YPL039W_p | Putative protein of unknown function; YPL039W is not an essential gene |
YCL001W-A_p | 5.39 | 3.56E-8 | YCL001W-A_p | Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III |
YNL239W | 5.37 | 4.01E-8 | LAP3 | Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH |
YOR120W | 5.30 | 5.78E-8 | GCY1 | Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication |
YKR076W | 5.16 | 1.25E-7 | ECM4 | Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
YMR225C | 4.72 | 1.20E-6 | MRPL44 | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |
YPR032W | 4.68 | 1.43E-6 | SRO7 | Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication |
YGR286C | 4.61 | 1.97E-6 | BIO2 | Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant |
YFR008W | 4.54 | 2.83E-6 | FAR7 | Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress |
YIL141W_d | 4.35 | 6.95E-6 | YIL141W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |