Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDL143W | 6.34 | 1.13E-10 | 1.43 | CCT4 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YOL040C | 4.91 | 4.54E-7 | 0.37 | RPS15 | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 |
YHR170W | 4.54 | 2.86E-6 | 0.11 | NMD3 | Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex |
YHR069C | 4.43 | 4.78E-6 | 0.73 | RRP4 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) |
YDL029W | 3.70 | 1.08E-4 | 0.02 | ARP2 | Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity |
YJR007W | 3.68 | 1.18E-4 | 0.39 | SUI2 | Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress |
YPR165W | 3.29 | 5.08E-4 | 8.58E-4 | RHO1 | GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) |
YPR190C | 3.28 | 5.10E-4 | 0.19 | RPC82 | RNA polymerase III subunit C82 |
YBR265W | 3.09 | 9.86E-4 | 9.16E-4 | TSC10 | 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family |
YDL028C | 3.09 | 9.90E-4 | 0.08 | MPS1 | Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p |
YPR016C | 3.02 | 0.00128 | 0.08 | TIF6 | Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits |
YDR087C | 2.94 | 0.00165 | 0.15 | RRP1 | Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles |
YNL188W | 2.79 | 0.00263 | 0.09 | KAR1 | Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p |
YOR257W | 2.70 | 0.00348 | 0.00 | CDC31 | Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation |
YNL113W | 2.70 | 0.00350 | 0.04 | RPC19 | RNA polymerase subunit AC19, common to RNA polymerases I and III |