Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKR026C | 11.10 | 9.12E-29 | GCN3 | Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression |
YER161C | 9.19 | 1.89E-20 | SPT2 | Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins |
YPL250C | 8.46 | 1.31E-17 | ICY2 | Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate |
YDR354W | 7.43 | 5.34E-14 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
YFR034C | 7.19 | 3.13E-13 | PHO4 | Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability |
YDR008C_d | 6.86 | 3.55E-12 | YDR008C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YGR020C | 6.83 | 4.37E-12 | VMA7 | Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane |
YLR122C_d | 6.51 | 3.67E-11 | YLR122C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C |
YOR121C_d | 6.04 | 7.70E-10 | YOR121C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W |
YKL211C | 5.66 | 7.67E-9 | TRP3 | Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p |
YMR202W | 5.61 | 1.01E-8 | ERG2 | C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis |
YMR020W | 5.24 | 8.02E-8 | FMS1 | Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis |
YHR018C | 5.08 | 1.84E-7 | ARG4 | Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway |
YDR007W | 4.94 | 3.98E-7 | TRP1 | Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) |
YJL126W | 4.87 | 5.70E-7 | NIT2 | Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member |