Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YKR071C | 7.34 | 1.08E-13 | 0.95 | DRE2 | Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress |
YDL045C | 7.16 | 4.06E-13 | 0.95 | FAD1 | Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin |
YOR176W | 6.21 | 2.60E-10 | 0.34 | HEM15 | Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway |
YDR527W | 5.87 | 2.12E-9 | 0.94 | RBA50 | Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 |
YOR207C | 4.94 | 3.95E-7 | 0.60 | RET1 | Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs |
YJL156C | 4.34 | 7.06E-6 | 0.13 | SSY5 | Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p |
YHR024C | 4.21 | 1.25E-5 | 0.16 | MAS2 | Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins |
YOR116C | 4.06 | 2.48E-5 | 0.01 | RPO31 | RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 |
YEL034W | 4.05 | 2.55E-5 | 0.31 | HYP2 | Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication |
YGL103W | 3.75 | 9.00E-5 | 0.16 | RPL28 | Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance |
YPR082C | 3.59 | 1.67E-4 | 0.05 | DIB1 | 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein |
YGL238W | 3.53 | 2.04E-4 | 0.05 | CSE1 | Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation |
YHR069C | 3.48 | 2.49E-4 | 0.03 | RRP4 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) |
YLR457C | 3.45 | 2.80E-4 | 0.02 | NBP1 | Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication |
YER003C | 3.43 | 3.02E-4 | 0.21 | PMI40 | Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation |