Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR354W | 7.59 | 1.55E-14 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
YDR008C_d | 6.78 | 6.05E-12 | YDR008C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YDR007W | 6.27 | 1.83E-10 | TRP1 | Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) |
YKL006W | 5.51 | 1.83E-8 | RPL14A | Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication |
YPL017C | 5.01 | 2.73E-7 | IRC15 | Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci |
YLR194C | 4.79 | 8.39E-7 | YLR194C | Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress |
YEL009C | 4.54 | 2.85E-6 | GCN4 | Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels |
YMR194W | 4.34 | 7.29E-6 | RPL36A | Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication |
YKL077W_p | 4.10 | 2.08E-5 | YKL077W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole |
YPR075C | 3.97 | 3.66E-5 | OPY2 | Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress |
YMR216C | 3.93 | 4.31E-5 | SKY1 | SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 |
YGR121W-A_p | 3.85 | 5.92E-5 | YGR121W-A_p | Putative protein of unknown function |
YPL114W_d | 3.58 | 1.69E-4 | YPL114W_d | Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index |
YPR193C | 3.58 | 1.75E-4 | HPA2 | Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity |
YPL015C | 3.53 | 2.12E-4 | HST2 | Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export |