Deletion Strain | FD score | P-value | Gene | Gene Description |
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YMR311C | 4.73 | 1.13E-6 | GLC8 | Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress |
YLR312C_p | 4.55 | 2.67E-6 | YLR312C_p | Putative protein of unknown function |
YIL015W | 4.42 | 5.01E-6 | BAR1 | Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest |
YOL108C | 4.04 | 2.70E-5 | INO4 | Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain |
YDR479C | 4.02 | 2.96E-5 | PEX29 | Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress |
YLR350W | 3.69 | 1.13E-4 | ORM2 | Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress |
YOR096W | 3.66 | 1.24E-4 | RPS7A | Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication |
YDL168W | 3.60 | 1.61E-4 | SFA1 | Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress |
YAL005C | 3.53 | 2.08E-4 | SSA1 | ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils |
YBR146W | 3.51 | 2.22E-4 | MRPS9 | Mitochondrial ribosomal protein of the small subunit |
YOR193W | 3.48 | 2.49E-4 | PEX27 | Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p |
YNR071C_p | 3.46 | 2.72E-4 | YNR071C_p | Putative aldose 1-epimerase |
YOL052C | 3.44 | 2.86E-4 | SPE2 | S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically |
YPL138C | 3.42 | 3.13E-4 | SPP1 | Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein |
YHR202W_p | 3.36 | 3.93E-4 | YHR202W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization |