Aminomethylbenzodioxan

2,3-dihydro-1,4-benzodioxin-3-ylmethanamine

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2039
Screen concentration 200.0 μM
Source Chembridge (Fragment library)
PubChem CID 15053
SMILES C1C(OC2=CC=CC=C2O1)CN
Standardized SMILES NCC1COc2ccccc2O1
Molecular weight 165.1891
ALogP 0.82
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 5.26
% growth inhibition (Hom. pool) 4.37


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 15053
Download HIP data (tab-delimited text)  (excel)
Gene:HEM15(YOR176W)|FD-Score:3.37|P-value:3.78E-4|Clearance:0.12||SGD DESC:Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway Gene:HEM2(YGL040C)|FD-Score:3.25|P-value:5.77E-4|Clearance:0.05||SGD DESC:Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus Gene:INN1(YNL152W)|FD-Score:4.81|P-value:7.51E-7|Clearance:1.1||SGD DESC:Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis Gene:MTR10(YOR160W)|FD-Score:3.15|P-value:8.06E-4|Clearance:0.01||SGD DESC:Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress Gene:MTR3(YGR158C)|FD-Score:3.2|P-value:6.89E-4|Clearance:0.05||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) Gene:RPC37(YKR025W)|FD-Score:3.5|P-value:2.29E-4|Clearance:0.14||SGD DESC:RNA polymerase III subunit C37 Gene:SCC4(YER147C)|FD-Score:3.71|P-value:1.03E-4|Clearance:0.21||SGD DESC:Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX Gene:SNP1(YIL061C)|FD-Score:-3.59|P-value:1.67E-4|Clearance:0||SGD DESC:Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress Gene:YNL114C(YNL114C_d)|FD-Score:3.15|P-value:8.30E-4|Clearance:0.06||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit Gene:HEM15(YOR176W)|FD-Score:3.37|P-value:3.78E-4|Clearance:0.12||SGD DESC:Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway Gene:HEM2(YGL040C)|FD-Score:3.25|P-value:5.77E-4|Clearance:0.05||SGD DESC:Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus Gene:INN1(YNL152W)|FD-Score:4.81|P-value:7.51E-7|Clearance:1.1||SGD DESC:Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis Gene:MTR10(YOR160W)|FD-Score:3.15|P-value:8.06E-4|Clearance:0.01||SGD DESC:Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress Gene:MTR3(YGR158C)|FD-Score:3.2|P-value:6.89E-4|Clearance:0.05||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) Gene:RPC37(YKR025W)|FD-Score:3.5|P-value:2.29E-4|Clearance:0.14||SGD DESC:RNA polymerase III subunit C37 Gene:SCC4(YER147C)|FD-Score:3.71|P-value:1.03E-4|Clearance:0.21||SGD DESC:Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX Gene:SNP1(YIL061C)|FD-Score:-3.59|P-value:1.67E-4|Clearance:0||SGD DESC:Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress Gene:YNL114C(YNL114C_d)|FD-Score:3.15|P-value:8.30E-4|Clearance:0.06||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 15053
Download HOP data (tab-delimited text)  (excel)
Gene:AAH1(YNL141W)|FD-Score:3.13|P-value:8.75E-4||SGD DESC:Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome Gene:BAR1(YIL015W)|FD-Score:4.42|P-value:5.01E-6||SGD DESC:Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest Gene:BNR1(YIL159W)|FD-Score:3.25|P-value:5.79E-4||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 Gene:COQ6(YGR255C)|FD-Score:-3.34|P-value:4.18E-4||SGD DESC:Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS) Gene:COX13(YGL191W)|FD-Score:-4.26|P-value:1.03E-5||SGD DESC:Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes Gene:DAS1(YJL149W)|FD-Score:-3.48|P-value:2.51E-4||SGD DESC:Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C Gene:FPR1(YNL135C)|FD-Score:3.12|P-value:9.11E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function Gene:GLC8(YMR311C)|FD-Score:4.73|P-value:1.13E-6||SGD DESC:Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress Gene:HOT13(YKL084W)|FD-Score:3.14|P-value:8.59E-4||SGD DESC:Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc Gene:HUA1(YGR268C)|FD-Score:3.15|P-value:8.11E-4||SGD DESC:Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly Gene:INO4(YOL108C)|FD-Score:4.04|P-value:2.70E-5||SGD DESC:Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain Gene:MRPS9(YBR146W)|FD-Score:3.51|P-value:2.22E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:OPY1(YBR129C)|FD-Score:-3.64|P-value:1.36E-4||SGD DESC:Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:ORM2(YLR350W)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress Gene:PEX27(YOR193W)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p Gene:PEX29(YDR479C)|FD-Score:4.02|P-value:2.96E-5||SGD DESC:Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress Gene:PRM9(YAR031W)|FD-Score:3.3|P-value:4.84E-4||SGD DESC:Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family Gene:RAS2(YNL098C)|FD-Score:-4.11|P-value:1.98E-5||SGD DESC:GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes Gene:RPS7A(YOR096W)|FD-Score:3.66|P-value:1.24E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication Gene:RRI1(YDL216C)|FD-Score:-3.87|P-value:5.55E-5||SGD DESC:Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling Gene:SFA1(YDL168W)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress Gene:SOK1(YDR006C)|FD-Score:-3.47|P-value:2.61E-4||SGD DESC:Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 Gene:SPE2(YOL052C)|FD-Score:3.44|P-value:2.86E-4||SGD DESC:S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically Gene:SPP1(YPL138C)|FD-Score:3.42|P-value:3.13E-4||SGD DESC:Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein Gene:SSA1(YAL005C)|FD-Score:3.53|P-value:2.08E-4||SGD DESC:ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils Gene:SUN4(YNL066W)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family Gene:TMA19(YKL056C)|FD-Score:3.16|P-value:7.75E-4||SGD DESC:Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress Gene:YBR134W(YBR134W_d)|FD-Score:-5.94|P-value:1.46E-9||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR202W(YHR202W_p)|FD-Score:3.36|P-value:3.93E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization Gene:YJL150W(YJL150W_d)|FD-Score:-3.15|P-value:8.22E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR312C(YLR312C_p)|FD-Score:4.55|P-value:2.67E-6||SGD DESC:Putative protein of unknown function Gene:YNR071C(YNR071C_p)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Putative aldose 1-epimerase Gene:YOL097W-A(YOL097W-A_p)|FD-Score:3.31|P-value:4.67E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:AAH1(YNL141W)|FD-Score:3.13|P-value:8.75E-4||SGD DESC:Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome Gene:BAR1(YIL015W)|FD-Score:4.42|P-value:5.01E-6||SGD DESC:Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest Gene:BNR1(YIL159W)|FD-Score:3.25|P-value:5.79E-4||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 Gene:COQ6(YGR255C)|FD-Score:-3.34|P-value:4.18E-4||SGD DESC:Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS) Gene:COX13(YGL191W)|FD-Score:-4.26|P-value:1.03E-5||SGD DESC:Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes Gene:DAS1(YJL149W)|FD-Score:-3.48|P-value:2.51E-4||SGD DESC:Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C Gene:FPR1(YNL135C)|FD-Score:3.12|P-value:9.11E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function Gene:GLC8(YMR311C)|FD-Score:4.73|P-value:1.13E-6||SGD DESC:Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress Gene:HOT13(YKL084W)|FD-Score:3.14|P-value:8.59E-4||SGD DESC:Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc Gene:HUA1(YGR268C)|FD-Score:3.15|P-value:8.11E-4||SGD DESC:Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly Gene:INO4(YOL108C)|FD-Score:4.04|P-value:2.70E-5||SGD DESC:Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain Gene:MRPS9(YBR146W)|FD-Score:3.51|P-value:2.22E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:OPY1(YBR129C)|FD-Score:-3.64|P-value:1.36E-4||SGD DESC:Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:ORM2(YLR350W)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress Gene:PEX27(YOR193W)|FD-Score:3.48|P-value:2.49E-4||SGD DESC:Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p Gene:PEX29(YDR479C)|FD-Score:4.02|P-value:2.96E-5||SGD DESC:Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress Gene:PRM9(YAR031W)|FD-Score:3.3|P-value:4.84E-4||SGD DESC:Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family Gene:RAS2(YNL098C)|FD-Score:-4.11|P-value:1.98E-5||SGD DESC:GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes Gene:RPS7A(YOR096W)|FD-Score:3.66|P-value:1.24E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication Gene:RRI1(YDL216C)|FD-Score:-3.87|P-value:5.55E-5||SGD DESC:Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling Gene:SFA1(YDL168W)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress Gene:SOK1(YDR006C)|FD-Score:-3.47|P-value:2.61E-4||SGD DESC:Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 Gene:SPE2(YOL052C)|FD-Score:3.44|P-value:2.86E-4||SGD DESC:S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically Gene:SPP1(YPL138C)|FD-Score:3.42|P-value:3.13E-4||SGD DESC:Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein Gene:SSA1(YAL005C)|FD-Score:3.53|P-value:2.08E-4||SGD DESC:ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils Gene:SUN4(YNL066W)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family Gene:TMA19(YKL056C)|FD-Score:3.16|P-value:7.75E-4||SGD DESC:Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress Gene:YBR134W(YBR134W_d)|FD-Score:-5.94|P-value:1.46E-9||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR202W(YHR202W_p)|FD-Score:3.36|P-value:3.93E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization Gene:YJL150W(YJL150W_d)|FD-Score:-3.15|P-value:8.22E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR312C(YLR312C_p)|FD-Score:4.55|P-value:2.67E-6||SGD DESC:Putative protein of unknown function Gene:YNR071C(YNR071C_p)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Putative aldose 1-epimerase Gene:YOL097W-A(YOL097W-A_p)|FD-Score:3.31|P-value:4.67E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YNL152W4.817.51E-71.10INN1Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
YER147C3.711.03E-40.21SCC4Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
YKR025W3.502.29E-40.14RPC37RNA polymerase III subunit C37
YOR176W3.373.78E-40.12HEM15Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
YGL040C3.255.77E-40.05HEM2Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
YGR158C3.206.89E-40.05MTR3Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
YOR160W3.158.06E-40.01MTR10Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
YNL114C_d3.158.30E-40.06YNL114C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
YLL008W3.080.001030.03DRS1Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles
YLR153C3.050.001150.01ACS2Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
YER094C3.040.001200.02PUP3Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
YLR029C3.010.001290.07RPL15ARibosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
YKL172W2.940.001630.02EBP2Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
YGL018C2.920.001740.04JAC1Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
YJR046W2.880.002000.12TAH11DNA replication licensing factor, required for pre-replication complex assembly

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YMR311C4.731.13E-6GLC8Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress
YLR312C_p4.552.67E-6YLR312C_pPutative protein of unknown function
YIL015W4.425.01E-6BAR1Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
YOL108C4.042.70E-5INO4Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
YDR479C4.022.96E-5PEX29Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
YLR350W3.691.13E-4ORM2Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
YOR096W3.661.24E-4RPS7AProtein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication
YDL168W3.601.61E-4SFA1Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress
YAL005C3.532.08E-4SSA1ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils
YBR146W3.512.22E-4MRPS9Mitochondrial ribosomal protein of the small subunit
YOR193W3.482.49E-4PEX27Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p
YNR071C_p3.462.72E-4YNR071C_pPutative aldose 1-epimerase
YOL052C3.442.86E-4SPE2S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
YPL138C3.423.13E-4SPP1Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein
YHR202W_p3.363.93E-4YHR202W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization

GO enrichment analysis for SGTC_2039
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0951.99E-13SGTC_12550566-0045 221.0 μMChemDiv (Drug-like library)27884690.0714286excess fatty acid
0.0872.43E-11SGTC_7431275-0778 158.0 μMChemDiv (Drug-like library)28492570.0961538excess fatty acid
0.0723.06E-8SGTC_30059076496 71.4 μMChembridge (Drug-like library)213684100.0689655
0.0691.03E-7SGTC_5414513-1321 94.0 μMChemDiv (Drug-like library)7475150.0555556
0.0648.04E-7SGTC_20295175081 200.0 μMChembridge (Fragment library)13808760.0833333
0.0621.99E-6SGTC_7950685-0265 78.0 μMChemDiv (Drug-like library)3027540.0740741excess fatty acid
0.0596.55E-6SGTC_23399000433 200.0 μMChembridge (Fragment library)29889540.142857
0.0552.07E-5SGTC_1117retinoic acid 1.1 μMTimTec (Natural product library)4447950.03125
0.0501.13E-4SGTC_21595658611 73.8 μMChembridge (Fragment library)7938440.107143
0.0501.18E-4SGTC_32939120939 62.0 μMChembridge (Drug-like library)9340870.0806452
0.0501.37E-4SGTC_208k072-0098 12.4 μMChemDiv (Drug-like library)59489010.0754717heme biosynthesis & mitochondrial translocase
0.0482.59E-4SGTC_13101188-0297 994.0 nMChemDiv (Drug-like library)15883520.0869565azole & statin
0.0455.38E-4SGTC_29799012552 45.5 μMChembridge (Drug-like library)171009050.0701754
0.0455.90E-4SGTC_14414106-0040 13.0 μMChemDiv (Drug-like library)29041800.118644
0.0420.00113SGTC_2670beta-carotene 100.0 μMMicrosource (Natural product library)52804890.0357143

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_571k831-010644.2 μM0.4545454783639ChemDiv (Drug-like library)339.793962.86815
SGTC_3531988-117558.3 μM0.3953492788357ChemDiv (Drug-like library)269.29522.39413unfolded protein response
SGTC_9073448-698675.5 μM0.384615590582ChemDiv (Drug-like library)352.307813.35126
SGTC_1250133-000711.75 μM0.35483926541ChemDiv (Drug-like library)360.400962.96906DNA intercalators
SGTC_13181280-3875124 μM0.354839373245ChemDiv (Drug-like library)316.34843.105
SGTC_5313788-1495174 μM0.342896655ChemDiv (Drug-like library)299.321182.37814unfolded protein response
SGTC_3384055-0136114 μM0.3076922900563ChemDiv (Drug-like library)286.30581.93515
SGTC_7033875-007571.8 μM0.2833332850814ChemDiv (Drug-like library)348.373642.05217
SGTC_3135912774249.47 μM0.2807023643468Chembridge (Drug-like library)427.45041.77316
SGTC_2300797669771.57 μM0.2444442236109Chembridge (Fragment library)238.756362.28912ERG2