| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YOR186W_p | 10.00 | 5.54E-24 | YOR186W_p | Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication |
| YGR078C | 8.28 | 5.99E-17 | PAC10 | Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding |
| YNL005C | 5.90 | 1.86E-9 | MRP7 | Mitochondrial ribosomal protein of the large subunit |
| YIL099W | 5.86 | 2.26E-9 | SGA1 | Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation |
| YDR537C_d | 5.74 | 4.78E-9 | YDR537C_d | Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W |
| YIL131C | 5.25 | 7.41E-8 | FKH1 | Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication |
| YML094C-A_d | 5.19 | 1.06E-7 | YML094C-A_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO |
| YHR139C | 5.10 | 1.71E-7 | SPS100 | Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin |
| YDL025C | 5.01 | 2.69E-7 | RTK1 | Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress |
| YER004W | 4.85 | 6.05E-7 | FMP52 | Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation |
| YNL121C | 4.84 | 6.51E-7 | TOM70 | Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication |
| YLR200W | 4.48 | 3.76E-6 | YKE2 | Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin |
| YCR033W | 4.45 | 4.33E-6 | SNT1 | Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance |
| YGR092W | 4.25 | 1.07E-5 | DBF2 | Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis |
| YPR074C | 4.01 | 3.00E-5 | TKL1 | Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication |
