Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDL205C | 15.90 | 1.43E-57 | 2.45 | HEM3 | Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme |
YDR232W | 14.50 | 6.98E-48 | 2.45 | HEM1 | 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p |
YDL196W_d | 12.30 | 3.62E-35 | 2.45 | YDL196W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 |
YDR047W | 11.00 | 1.83E-28 | 2.45 | HEM12 | Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda |
YMR203W | 10.90 | 5.32E-28 | 2.45 | TOM40 | Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore |
YIL126W | 8.45 | 1.42E-17 | 0.55 | STH1 | ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p |
YLR033W | 7.91 | 1.30E-15 | 1.45 | RSC58 | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
YBR192W | 6.45 | 5.46E-11 | 0.81 | RIM2 | Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family |
YNL244C | 5.64 | 8.42E-9 | 0.12 | SUI1 | Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase |
YML127W | 5.52 | 1.73E-8 | 0.01 | RSC9 | Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway |
YDL126C | 5.50 | 1.87E-8 | 0.46 | CDC48 | AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP |
YMR033W | 5.04 | 2.28E-7 | 0.10 | ARP9 | Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation |
YGL093W | 4.94 | 3.93E-7 | 0.14 | SPC105 | Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components |
YDR145W | 4.80 | 8.10E-7 | 0.04 | TAF12 | Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A |
YNL112W | 4.76 | 9.70E-7 | 0.13 | DBP2 | ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites |