Deletion Strain | FD score | P-value | Gene | Gene Description |
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YHR049W | 6.39 | 8.35E-11 | FSH1 | Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2 |
YPL069C | 5.96 | 1.30E-9 | BTS1 | Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic |
YPL115C | 5.83 | 2.85E-9 | BEM3 | Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly |
YMR271C | 5.62 | 9.46E-9 | URA10 | Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication |
YER110C | 4.97 | 3.41E-7 | KAP123 | Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 |
YBL021C | 4.68 | 1.45E-6 | HAP3 | Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding |
YBR021W | 4.67 | 1.52E-6 | FUR4 | Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation |
YOR369C | 4.27 | 9.62E-6 | RPS12 | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog |
YNL195C_p | 4.21 | 1.27E-5 | YNL195C_p | Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YGL031C | 3.95 | 3.97E-5 | RPL24A | Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication |
YNL249C | 3.91 | 4.60E-5 | MPA43 | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YPL097W | 3.90 | 4.73E-5 | MSY1 | Mitochondrial tyrosyl-tRNA synthetase |
YKR040C_d | 3.87 | 5.48E-5 | YKR040C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W |
YIL013C | 3.86 | 5.59E-5 | PDR11 | ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth |
YDR176W | 3.86 | 5.74E-5 | NGG1 | Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex |