Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPL007C | 6.28 | 1.67E-10 | 1.22 | TFC8 | One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 |
YGR103W | 5.06 | 2.11E-7 | 0.06 | NOP7 | Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation |
YJL086C_d | 5.00 | 2.93E-7 | 0.19 | YJL086C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 |
YGR114C_d | 4.81 | 7.55E-7 | 0.03 | YGR114C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6 |
YJL014W | 4.78 | 8.95E-7 | 0.70 | CCT3 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YGR116W | 4.07 | 2.33E-5 | 0.08 | SPT6 | Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region |
YKL012W | 4.00 | 3.22E-5 | 0.04 | PRP40 | U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex |
YBR252W | 3.96 | 3.80E-5 | 0.20 | DUT1 | deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate |
YJL111W | 3.76 | 8.47E-5 | 0.07 | CCT7 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance |
YDR478W | 3.69 | 1.10E-4 | 0.06 | SNM1 | Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP |
YDL235C | 3.64 | 1.38E-4 | 0.14 | YPD1 | Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus |
YBR236C | 3.50 | 2.32E-4 | 0.03 | ABD1 | Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA |
YDR212W | 3.47 | 2.62E-4 | 5.15E-4 | TCP1 | Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein |
YLR310C | 3.47 | 2.63E-4 | 0.10 | CDC25 | Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 |
YPR016C | 3.37 | 3.78E-4 | 0.14 | TIF6 | Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits |