Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBR058C-A | 9.16 | 2.70E-20 | TSC3 | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
YDR127W | 7.94 | 1.03E-15 | ARO1 | Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids |
YLR148W | 7.13 | 5.12E-13 | PEP3 | Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis |
YDL022W | 6.82 | 4.52E-12 | GPD1 | NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity |
YFL030W | 6.19 | 3.04E-10 | AGX1 | Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases |
YDR126W | 5.69 | 6.26E-9 | SWF1 | Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion |
YGR171C | 5.11 | 1.59E-7 | MSM1 | Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p |
YBR094W | 5.09 | 1.77E-7 | PBY1 | Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress |
YGL026C | 5.01 | 2.68E-7 | TRP5 | Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis |
YDR514C | 4.89 | 5.10E-7 | YDR514C | Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication |
YKL211C | 4.56 | 2.58E-6 | TRP3 | Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p |
YCL069W | 4.51 | 3.30E-6 | VBA3 | Permease of basic amino acids in the vacuolar membrane |
YFR036W | 4.50 | 3.44E-6 | CDC26 | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition |
YPL148C | 4.49 | 3.55E-6 | PPT2 | Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation |
YCR006C_d | 4.31 | 8.10E-6 | YCR006C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |