Deletion Strain | FD score | P-value | Gene | Gene Description |
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YOR246C | 12.60 | 1.17E-36 | ENV9 | Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts |
YHR163W | 8.70 | 1.60E-18 | SOL3 | 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication |
YHR098C | 7.38 | 7.86E-14 | SFB3 | Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p |
YDR203W_d | 5.87 | 2.15E-9 | YDR203W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YJR033C | 5.41 | 3.21E-8 | RAV1 | Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate |
YGL005C | 4.73 | 1.14E-6 | COG7 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
YDR174W | 4.27 | 9.63E-6 | HMO1 | Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase |
YHL024W | 4.12 | 1.88E-5 | RIM4 | Putative RNA-binding protein required for the expression of early and middle sporulation genes |
YLR184W_d | 4.00 | 3.12E-5 | YLR184W_d | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YFL054C_p | 3.93 | 4.18E-5 | YFL054C_p | Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol |
YJL172W | 3.83 | 6.46E-5 | CPS1 | Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions |
YMR205C | 3.76 | 8.54E-5 | PFK2 | Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes |
YIR033W | 3.58 | 1.73E-4 | MGA2 | ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting |
YHL026C_p | 3.57 | 1.80E-4 | YHL026C_p | Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) |
YNR057C | 3.55 | 1.89E-4 | BIO4 | Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels |