4077-0173

9-chloro-2-phenyl-5,10b-dihydro-1H-pyrazolo[1,5-c][1,3]benzoxazine

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_209
Screen concentration 175.6 μM
Source ChemDiv (Drug-like library)
PubChem CID 15993494
SMILES C1C2C3=C(C=CC(=C3)Cl)OCN2N=C1C4=CC=CC=C4
Standardized SMILES Clc1ccc2OCN3N=C(CC3c2c1)c4ccccc4
Molecular weight 284.7402
ALogP 3.54
H-bond donor count 0
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 17.98
% growth inhibition (Hom. pool) 12.67


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 15993494
Download HIP data (tab-delimited text)  (excel)
Gene:RRP9(YPR137W)|FD-Score:3.48|P-value:2.50E-4|Clearance:0.6||SGD DESC:Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein Gene:SEC62(YPL094C)|FD-Score:-3.17|P-value:7.67E-4|Clearance:0||SGD DESC:Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:RRP9(YPR137W)|FD-Score:3.48|P-value:2.50E-4|Clearance:0.6||SGD DESC:Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein Gene:SEC62(YPL094C)|FD-Score:-3.17|P-value:7.67E-4|Clearance:0||SGD DESC:Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 15993494
Download HOP data (tab-delimited text)  (excel)
Gene:BEM3(YPL115C)|FD-Score:-3.46|P-value:2.65E-4||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly Gene:BIO4(YNR057C)|FD-Score:3.55|P-value:1.89E-4||SGD DESC:Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels Gene:COG7(YGL005C)|FD-Score:4.73|P-value:1.14E-6||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CPS1(YJL172W)|FD-Score:3.83|P-value:6.46E-5||SGD DESC:Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions Gene:CRN1(YLR429W)|FD-Score:3.23|P-value:6.27E-4||SGD DESC:Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly Gene:DMA1(YHR115C)|FD-Score:-3.5|P-value:2.36E-4||SGD DESC:Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma2p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8 protein, similar to human Chfr; contains FHA and RING finger Gene:ENV9(YOR246C)|FD-Score:12.6|P-value:1.17E-36||SGD DESC:Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts Gene:HMO1(YDR174W)|FD-Score:4.27|P-value:9.63E-6||SGD DESC:Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase Gene:HSM3(YBR272C)|FD-Score:3.18|P-value:7.42E-4||SGD DESC:Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation Gene:IRC15(YPL017C)|FD-Score:-3.76|P-value:8.54E-5||SGD DESC:Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci Gene:MGA2(YIR033W)|FD-Score:3.58|P-value:1.73E-4||SGD DESC:ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting Gene:PFK2(YMR205C)|FD-Score:3.76|P-value:8.54E-5||SGD DESC:Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes Gene:RAD23(YEL037C)|FD-Score:-3.57|P-value:1.80E-4||SGD DESC:Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover Gene:RAV1(YJR033C)|FD-Score:5.41|P-value:3.21E-8||SGD DESC:Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate Gene:RAV2(YDR202C)|FD-Score:3.27|P-value:5.36E-4||SGD DESC:Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme Gene:RDH54(YBR073W)|FD-Score:3.25|P-value:5.82E-4||SGD DESC:DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p Gene:RIM4(YHL024W)|FD-Score:4.12|P-value:1.88E-5||SGD DESC:Putative RNA-binding protein required for the expression of early and middle sporulation genes Gene:RPL11B(YGR085C)|FD-Score:3.17|P-value:7.53E-4||SGD DESC:Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication Gene:SFB3(YHR098C)|FD-Score:7.38|P-value:7.86E-14||SGD DESC:Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p Gene:SOL3(YHR163W)|FD-Score:8.7|P-value:1.60E-18||SGD DESC:6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication Gene:SPH1(YLR313C)|FD-Score:-3.7|P-value:1.07E-4||SGD DESC:Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p Gene:YDR203W(YDR203W_d)|FD-Score:5.87|P-value:2.15E-9||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR246W-A(YDR246W-A_p)|FD-Score:-3.12|P-value:9.13E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YFL054C(YFL054C_p)|FD-Score:3.93|P-value:4.18E-5||SGD DESC:Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol Gene:YHL026C(YHL026C_p)|FD-Score:3.57|P-value:1.80E-4||SGD DESC:Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) Gene:YKL097C(YKL097C_d)|FD-Score:-3.69|P-value:1.13E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species Gene:YLR111W(YLR111W_d)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR184W(YLR184W_d)|FD-Score:4|P-value:3.12E-5||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR434C(YLR434C_d)|FD-Score:3.34|P-value:4.24E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W Gene:YNR064C(YNR064C)|FD-Score:3.36|P-value:3.94E-4||SGD DESC:Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides Gene:BEM3(YPL115C)|FD-Score:-3.46|P-value:2.65E-4||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly Gene:BIO4(YNR057C)|FD-Score:3.55|P-value:1.89E-4||SGD DESC:Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels Gene:COG7(YGL005C)|FD-Score:4.73|P-value:1.14E-6||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CPS1(YJL172W)|FD-Score:3.83|P-value:6.46E-5||SGD DESC:Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions Gene:CRN1(YLR429W)|FD-Score:3.23|P-value:6.27E-4||SGD DESC:Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly Gene:DMA1(YHR115C)|FD-Score:-3.5|P-value:2.36E-4||SGD DESC:Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma2p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8 protein, similar to human Chfr; contains FHA and RING finger Gene:ENV9(YOR246C)|FD-Score:12.6|P-value:1.17E-36||SGD DESC:Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts Gene:HMO1(YDR174W)|FD-Score:4.27|P-value:9.63E-6||SGD DESC:Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase Gene:HSM3(YBR272C)|FD-Score:3.18|P-value:7.42E-4||SGD DESC:Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation Gene:IRC15(YPL017C)|FD-Score:-3.76|P-value:8.54E-5||SGD DESC:Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci Gene:MGA2(YIR033W)|FD-Score:3.58|P-value:1.73E-4||SGD DESC:ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting Gene:PFK2(YMR205C)|FD-Score:3.76|P-value:8.54E-5||SGD DESC:Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes Gene:RAD23(YEL037C)|FD-Score:-3.57|P-value:1.80E-4||SGD DESC:Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover Gene:RAV1(YJR033C)|FD-Score:5.41|P-value:3.21E-8||SGD DESC:Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate Gene:RAV2(YDR202C)|FD-Score:3.27|P-value:5.36E-4||SGD DESC:Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme Gene:RDH54(YBR073W)|FD-Score:3.25|P-value:5.82E-4||SGD DESC:DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p Gene:RIM4(YHL024W)|FD-Score:4.12|P-value:1.88E-5||SGD DESC:Putative RNA-binding protein required for the expression of early and middle sporulation genes Gene:RPL11B(YGR085C)|FD-Score:3.17|P-value:7.53E-4||SGD DESC:Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication Gene:SFB3(YHR098C)|FD-Score:7.38|P-value:7.86E-14||SGD DESC:Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p Gene:SOL3(YHR163W)|FD-Score:8.7|P-value:1.60E-18||SGD DESC:6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication Gene:SPH1(YLR313C)|FD-Score:-3.7|P-value:1.07E-4||SGD DESC:Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p Gene:YDR203W(YDR203W_d)|FD-Score:5.87|P-value:2.15E-9||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YDR246W-A(YDR246W-A_p)|FD-Score:-3.12|P-value:9.13E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YFL054C(YFL054C_p)|FD-Score:3.93|P-value:4.18E-5||SGD DESC:Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol Gene:YHL026C(YHL026C_p)|FD-Score:3.57|P-value:1.80E-4||SGD DESC:Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) Gene:YKL097C(YKL097C_d)|FD-Score:-3.69|P-value:1.13E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species Gene:YLR111W(YLR111W_d)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR184W(YLR184W_d)|FD-Score:4|P-value:3.12E-5||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR434C(YLR434C_d)|FD-Score:3.34|P-value:4.24E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W Gene:YNR064C(YNR064C)|FD-Score:3.36|P-value:3.94E-4||SGD DESC:Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YPR137W3.482.50E-40.60RRP9Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
YKL172W2.880.001980.03EBP2Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
YGL201C2.850.002170.06MCM6Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p
YPR165W2.790.002620.07RHO1GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
YGL068W2.720.003260.11MNP1Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
YNL039W2.610.004470.14BDP1Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
YOR119C2.480.006590.02RIO1Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
YBR070C2.460.006880.18ALG14Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
YIL004C2.290.011100.03BET1Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins
YGR253C2.260.012000.01PUP2Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YHR148W2.250.012300.05IMP3Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
YLR424W2.200.014100.01SPP382Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation
YDR324C2.180.014500.03UTP4Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
YFL008W2.160.015500.01SMC1Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
YBR247C2.150.015900.00ENP1Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR246C12.601.17E-36ENV9Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
YHR163W8.701.60E-18SOL36-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication
YHR098C7.387.86E-14SFB3Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p
YDR203W_d5.872.15E-9YDR203W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR033C5.413.21E-8RAV1Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
YGL005C4.731.14E-6COG7Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YDR174W4.279.63E-6HMO1Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
YHL024W4.121.88E-5RIM4Putative RNA-binding protein required for the expression of early and middle sporulation genes
YLR184W_d4.003.12E-5YLR184W_dDubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL054C_p3.934.18E-5YFL054C_pPutative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YJL172W3.836.46E-5CPS1Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
YMR205C3.768.54E-5PFK2Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YIR033W3.581.73E-4MGA2ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
YHL026C_p3.571.80E-4YHL026C_pPutative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
YNR057C3.551.89E-4BIO4Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels

GO enrichment analysis for SGTC_209
No biological processes are significantly enriched (FDR < 0.1).

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.2122.72E-60SGTC_29679089538 49.9 μMChembridge (Drug-like library)7282160.111111
0.2114.33E-60SGTC_1534077-0274 519.7 μMChemDiv (Drug-like library)31219760.373134
0.2011.59E-54SGTC_2413inermin 26.1 μMTimTec (Natural product derivative library)915100.151515
0.1936.09E-50SGTC_21545570129 200.0 μMChembridge (Fragment library)6733660.0857143
0.1752.82E-41SGTC_30909117696 49.5 μMChembridge (Drug-like library)79238210.0857143
0.1484.66E-30SGTC_9831491-0821 12.2 μMChemDiv (Drug-like library)464951130.0547945
0.1404.23E-27SGTC_3364111-0029 111.0 μMChemDiv (Drug-like library)31311750.354839
0.1391.45E-26SGTC_23719071574 200.0 μMChembridge (Fragment library)455960390.0892857
0.1198.27E-20SGTC_2710st078562 53.7 μMTimTec (Natural product derivative library)172509080.0689655
0.1141.69E-18SGTC_8053852-0218 479.0 μMChemDiv (Drug-like library)66153550.13253ERAD & cell cycle
0.1133.68E-18SGTC_7334069-0007 56.1 μMChemDiv (Drug-like library)57174250.114286ERAD & cell cycle
0.1104.05E-17SGTC_204PMA1.184 62.4 μMChemDiv (Drug-like library)22522130.0864198TRP & mitochondrial translation
0.1095.42E-17SGTC_3071501-1223 22.3 μMChemDiv (Drug-like library)28303290.0821918
0.0985.96E-14SGTC_1789tunicamycin 25.0 nMICCB bioactive library238471770.045045unfolded protein response
0.0953.08E-13SGTC_1647st011722 22.4 μMTimTec (Natural product derivative library)28547830.132353

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_1534077-0274519.67 μM0.3731343121976ChemDiv (Drug-like library)384.8543635.49905
SGTC_3364111-0029111 μM0.3548393131175ChemDiv (Drug-like library)327.379183.52504
SGTC_3354077-025627.6 μM0.2794123121989ChemDiv (Drug-like library)363.27213.69404
SGTC_2731amoxapine43.43 μM0.2656252170Miscellaneous313.781442.89713
SGTC_5433844-1095191 μM0.2575764230703ChemDiv (Drug-like library)354.399682.70205ERG2
SGTC_1766st04541444.77 μM0.25253960TimTec (Natural product derivative library)273.671222.11214RPP1 & pyrimidine depletion
SGTC_465cgp-3715741 μM0.2380952688ICCB bioactive library324.224944.12612
SGTC_7473448-808738.7 μM0.2361115168703ChemDiv (Drug-like library)441.907362.99606
SGTC_3393091-483371.4 μM0.2258063240077ChemDiv (Drug-like library)272.686463.1713iron homeostasis
SGTC_1781st03872566.3 μM0.2258064270275TimTec (Natural product derivative library)301.767443.50413NEO1