Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YGR119C | 4.24 | 1.11E-5 | 0.40 | NUP57 | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) |
YJL010C | 4.17 | 1.51E-5 | 0.40 | NOP9 | Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain |
YCR057C | 4.08 | 2.22E-5 | 0.40 | PWP2 | Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis |
YLR147C | 3.80 | 7.25E-5 | 0.40 | SMD3 | Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 |
YPL169C | 3.79 | 7.68E-5 | 0.40 | MEX67 | Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP |
YIL150C | 3.39 | 3.53E-4 | 0.06 | MCM10 | Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins |
YBR202W | 3.33 | 4.39E-4 | 0.07 | MCM7 | Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex |
YFR002W | 3.26 | 5.64E-4 | 0.28 | NIC96 | Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) |
YNL308C | 2.98 | 0.00144 | 0.03 | KRI1 | Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p |
YDR429C | 2.95 | 0.00161 | 0.01 | TIF35 | eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation |
YPL238C_d | 2.93 | 0.00168 | 0.17 | YPL238C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W |
YBR196C | 2.77 | 0.00283 | 0.03 | PGI1 | Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation |
YBR060C | 2.73 | 0.00312 | 0.08 | ORC2 | Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p |
YGL172W | 2.65 | 0.00401 | 0.02 | NUP49 | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) |
YNL110C | 2.63 | 0.00424 | 0.03 | NOP15 | Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm |