5376439

7-methyl-2-phenyl-4,7a-dihydro-3aH-octahydro-1H-4,7-epoxyisoindole-1,3-dione

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2098
Screen concentration 882.5 nM
Source Chembridge (Fragment library)
PubChem CID 2844116
SMILES CC12C=CC(O1)C3C2C(=O)N(C3=O)C4=CC=CC=C4
Standardized SMILES CC12OC(C=C1)C3C2C(=O)N(C3=O)c4ccccc4
Molecular weight 255.2686
ALogP 1.05
H-bond donor count 0
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 7.52
% growth inhibition (Hom. pool) 3.67


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2844116
Download HIP data (tab-delimited text)  (excel)
Gene:ARC19(YKL013C)|FD-Score:-4.61|P-value:1.97E-6|Clearance:0||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:BBP1(YPL255W)|FD-Score:-3.98|P-value:3.40E-5|Clearance:0||SGD DESC:Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p Gene:DSN1(YIR010W)|FD-Score:3.74|P-value:9.04E-5|Clearance:0.01||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation Gene:ERG12(YMR208W)|FD-Score:5.52|P-value:1.65E-8|Clearance:0.56||SGD DESC:Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate Gene:FAS1(YKL182W)|FD-Score:3.74|P-value:9.23E-5|Clearance:0.18||SGD DESC:Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities Gene:NTR2(YKR022C)|FD-Score:3.15|P-value:8.08E-4|Clearance:0.02||SGD DESC:Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly Gene:PMI40(YER003C)|FD-Score:4.77|P-value:9.15E-7|Clearance:0.56||SGD DESC:Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation Gene:RPS5(YJR123W)|FD-Score:3.37|P-value:3.77E-4|Clearance:0.12||SGD DESC:Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7 Gene:RRP5(YMR229C)|FD-Score:-3.52|P-value:2.12E-4|Clearance:0||SGD DESC:RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress Gene:SEN2(YLR105C)|FD-Score:5.24|P-value:7.94E-8|Clearance:0.56||SGD DESC:Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease Gene:SPC42(YKL042W)|FD-Score:4.21|P-value:1.26E-5|Clearance:0.47||SGD DESC:Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane Gene:TAD2(YJL035C)|FD-Score:-3.45|P-value:2.80E-4|Clearance:0||SGD DESC:Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs Gene:TAF6(YGL112C)|FD-Score:3.25|P-value:5.85E-4|Clearance:0.09||SGD DESC:Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4 Gene:TAO3(YIL129C)|FD-Score:-4.15|P-value:1.68E-5|Clearance:0||SGD DESC:Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p Gene:TUB2(YFL037W)|FD-Score:3.55|P-value:1.89E-4|Clearance:0.19||SGD DESC:Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria Gene:USO1(YDL058W)|FD-Score:3.16|P-value:7.89E-4|Clearance:0.01||SGD DESC:Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex Gene:YDL221W(YDL221W_d)|FD-Score:-3.46|P-value:2.68E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13 Gene:YHC1(YLR298C)|FD-Score:3.13|P-value:8.64E-4|Clearance:0.19||SGD DESC:Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site Gene:ARC19(YKL013C)|FD-Score:-4.61|P-value:1.97E-6|Clearance:0||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:BBP1(YPL255W)|FD-Score:-3.98|P-value:3.40E-5|Clearance:0||SGD DESC:Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p Gene:DSN1(YIR010W)|FD-Score:3.74|P-value:9.04E-5|Clearance:0.01||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation Gene:ERG12(YMR208W)|FD-Score:5.52|P-value:1.65E-8|Clearance:0.56||SGD DESC:Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate Gene:FAS1(YKL182W)|FD-Score:3.74|P-value:9.23E-5|Clearance:0.18||SGD DESC:Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities Gene:NTR2(YKR022C)|FD-Score:3.15|P-value:8.08E-4|Clearance:0.02||SGD DESC:Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly Gene:PMI40(YER003C)|FD-Score:4.77|P-value:9.15E-7|Clearance:0.56||SGD DESC:Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation Gene:RPS5(YJR123W)|FD-Score:3.37|P-value:3.77E-4|Clearance:0.12||SGD DESC:Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7 Gene:RRP5(YMR229C)|FD-Score:-3.52|P-value:2.12E-4|Clearance:0||SGD DESC:RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress Gene:SEN2(YLR105C)|FD-Score:5.24|P-value:7.94E-8|Clearance:0.56||SGD DESC:Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease Gene:SPC42(YKL042W)|FD-Score:4.21|P-value:1.26E-5|Clearance:0.47||SGD DESC:Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane Gene:TAD2(YJL035C)|FD-Score:-3.45|P-value:2.80E-4|Clearance:0||SGD DESC:Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs Gene:TAF6(YGL112C)|FD-Score:3.25|P-value:5.85E-4|Clearance:0.09||SGD DESC:Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4 Gene:TAO3(YIL129C)|FD-Score:-4.15|P-value:1.68E-5|Clearance:0||SGD DESC:Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p Gene:TUB2(YFL037W)|FD-Score:3.55|P-value:1.89E-4|Clearance:0.19||SGD DESC:Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria Gene:USO1(YDL058W)|FD-Score:3.16|P-value:7.89E-4|Clearance:0.01||SGD DESC:Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex Gene:YDL221W(YDL221W_d)|FD-Score:-3.46|P-value:2.68E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13 Gene:YHC1(YLR298C)|FD-Score:3.13|P-value:8.64E-4|Clearance:0.19||SGD DESC:Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2844116
Download HOP data (tab-delimited text)  (excel)
Gene:ADR1(YDR216W)|FD-Score:3.14|P-value:8.56E-4||SGD DESC:Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization Gene:ALF1(YNL148C)|FD-Score:3.4|P-value:3.38E-4||SGD DESC:Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance Gene:ATP23(YNR020C)|FD-Score:3.36|P-value:3.84E-4||SGD DESC:Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p Gene:CHO2(YGR157W)|FD-Score:3.18|P-value:7.29E-4||SGD DESC:Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis Gene:COG7(YGL005C)|FD-Score:-3.16|P-value:7.93E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COS111(YBR203W)|FD-Score:3.14|P-value:8.42E-4||SGD DESC:Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:ERP6(YGL002W)|FD-Score:3.34|P-value:4.21E-4||SGD DESC:Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication Gene:GEM1(YAL048C)|FD-Score:-3.37|P-value:3.69E-4||SGD DESC:Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases Gene:GTO3(YMR251W)|FD-Score:4.68|P-value:1.44E-6||SGD DESC:Omega class glutathione transferase; putative cytosolic localization Gene:HXT3(YDR345C)|FD-Score:4.25|P-value:1.08E-5||SGD DESC:Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication Gene:MCM22(YJR135C)|FD-Score:3.43|P-value:3.05E-4||SGD DESC:Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4 Gene:MIP1(YOR330C)|FD-Score:-3.39|P-value:3.45E-4||SGD DESC:Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit Gene:NMA111(YNL123W)|FD-Score:-3.19|P-value:7.17E-4||SGD DESC:Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Gene:OPI1(YHL020C)|FD-Score:4.35|P-value:6.88E-6||SGD DESC:Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance Gene:PAC2(YER007W)|FD-Score:5.84|P-value:2.60E-9||SGD DESC:Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl Gene:PES4(YFR023W)|FD-Score:3.18|P-value:7.26E-4||SGD DESC:Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication Gene:PGM1(YKL127W)|FD-Score:3.29|P-value:5.08E-4||SGD DESC:Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism Gene:PHO80(YOL001W)|FD-Score:-3.27|P-value:5.39E-4||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling Gene:PIP2(YOR363C)|FD-Score:-3.36|P-value:3.94E-4||SGD DESC:Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication Gene:PSR2(YLR019W)|FD-Score:4.65|P-value:1.62E-6||SGD DESC:Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Gene:PUT1(YLR142W)|FD-Score:4.92|P-value:4.22E-7||SGD DESC:Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source Gene:RAD59(YDL059C)|FD-Score:-3.1|P-value:9.84E-4||SGD DESC:Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p Gene:REI1(YBR267W)|FD-Score:-3.16|P-value:8.02E-4||SGD DESC:Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network Gene:RMD6(YEL072W)|FD-Score:3.12|P-value:9.00E-4||SGD DESC:Protein required for sporulation Gene:RPO41(YFL036W)|FD-Score:3.77|P-value:8.06E-5||SGD DESC:Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation Gene:SAP4(YGL229C)|FD-Score:3.89|P-value:5.10E-5||SGD DESC:Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p Gene:SRF1(YDL133W)|FD-Score:3.41|P-value:3.28E-4||SGD DESC:Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients Gene:SRO7(YPR032W)|FD-Score:-3.27|P-value:5.39E-4||SGD DESC:Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication Gene:SWR1(YDR334W)|FD-Score:4.45|P-value:4.30E-6||SGD DESC:Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:TEF4(YKL081W)|FD-Score:3.14|P-value:8.37E-4||SGD DESC:Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex Gene:TSC3(YBR058C-A)|FD-Score:5.26|P-value:7.03E-8||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:TUB3(YML124C)|FD-Score:3.34|P-value:4.20E-4||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication Gene:TWF1(YGR080W)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly Gene:YBP2(YGL060W)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication Gene:YBR196C-A(YBR196C-A_p)|FD-Score:3.51|P-value:2.27E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR514C(YDR514C)|FD-Score:3.88|P-value:5.18E-5||SGD DESC:Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication Gene:YHR050W-A(YHR050W-A_p)|FD-Score:3.68|P-value:1.19E-4||SGD DESC:Protein of unknown function; identified by expression profiling and mass spectrometry Gene:YKR033C(YKR033C_d)|FD-Score:3.24|P-value:6.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80 Gene:YLR269C(YLR269C_d)|FD-Score:3.87|P-value:5.35E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YML053C(YML053C_p)|FD-Score:4.46|P-value:4.06E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene Gene:YML101C-A(YML101C-A_d)|FD-Score:3.98|P-value:3.40E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR141C(YMR141C_d)|FD-Score:3.16|P-value:8.00E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOL073C(YOL073C_p)|FD-Score:3.53|P-value:2.09E-4||SGD DESC:Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2 Gene:YOR277C(YOR277C_d)|FD-Score:3.66|P-value:1.25E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 Gene:YPK1(YKL126W)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication Gene:YPR027C(YPR027C_p)|FD-Score:3.65|P-value:1.30E-4||SGD DESC:Putative protein of unknown function Gene:YPR109W(YPR109W_p)|FD-Score:4.4|P-value:5.43E-6||SGD DESC:Predicted membrane protein; dipoid deletion strain has high budding index Gene:YVH1(YIR026C)|FD-Score:-3.89|P-value:4.97E-5||SGD DESC:Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases Gene:ADR1(YDR216W)|FD-Score:3.14|P-value:8.56E-4||SGD DESC:Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization Gene:ALF1(YNL148C)|FD-Score:3.4|P-value:3.38E-4||SGD DESC:Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance Gene:ATP23(YNR020C)|FD-Score:3.36|P-value:3.84E-4||SGD DESC:Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p Gene:CHO2(YGR157W)|FD-Score:3.18|P-value:7.29E-4||SGD DESC:Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis Gene:COG7(YGL005C)|FD-Score:-3.16|P-value:7.93E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COS111(YBR203W)|FD-Score:3.14|P-value:8.42E-4||SGD DESC:Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:ERP6(YGL002W)|FD-Score:3.34|P-value:4.21E-4||SGD DESC:Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication Gene:GEM1(YAL048C)|FD-Score:-3.37|P-value:3.69E-4||SGD DESC:Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases Gene:GTO3(YMR251W)|FD-Score:4.68|P-value:1.44E-6||SGD DESC:Omega class glutathione transferase; putative cytosolic localization Gene:HXT3(YDR345C)|FD-Score:4.25|P-value:1.08E-5||SGD DESC:Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication Gene:MCM22(YJR135C)|FD-Score:3.43|P-value:3.05E-4||SGD DESC:Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4 Gene:MIP1(YOR330C)|FD-Score:-3.39|P-value:3.45E-4||SGD DESC:Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit Gene:NMA111(YNL123W)|FD-Score:-3.19|P-value:7.17E-4||SGD DESC:Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Gene:OPI1(YHL020C)|FD-Score:4.35|P-value:6.88E-6||SGD DESC:Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance Gene:PAC2(YER007W)|FD-Score:5.84|P-value:2.60E-9||SGD DESC:Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl Gene:PES4(YFR023W)|FD-Score:3.18|P-value:7.26E-4||SGD DESC:Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication Gene:PGM1(YKL127W)|FD-Score:3.29|P-value:5.08E-4||SGD DESC:Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism Gene:PHO80(YOL001W)|FD-Score:-3.27|P-value:5.39E-4||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling Gene:PIP2(YOR363C)|FD-Score:-3.36|P-value:3.94E-4||SGD DESC:Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication Gene:PSR2(YLR019W)|FD-Score:4.65|P-value:1.62E-6||SGD DESC:Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Gene:PUT1(YLR142W)|FD-Score:4.92|P-value:4.22E-7||SGD DESC:Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source Gene:RAD59(YDL059C)|FD-Score:-3.1|P-value:9.84E-4||SGD DESC:Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p Gene:REI1(YBR267W)|FD-Score:-3.16|P-value:8.02E-4||SGD DESC:Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network Gene:RMD6(YEL072W)|FD-Score:3.12|P-value:9.00E-4||SGD DESC:Protein required for sporulation Gene:RPO41(YFL036W)|FD-Score:3.77|P-value:8.06E-5||SGD DESC:Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation Gene:SAP4(YGL229C)|FD-Score:3.89|P-value:5.10E-5||SGD DESC:Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p Gene:SRF1(YDL133W)|FD-Score:3.41|P-value:3.28E-4||SGD DESC:Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients Gene:SRO7(YPR032W)|FD-Score:-3.27|P-value:5.39E-4||SGD DESC:Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication Gene:SWR1(YDR334W)|FD-Score:4.45|P-value:4.30E-6||SGD DESC:Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:TEF4(YKL081W)|FD-Score:3.14|P-value:8.37E-4||SGD DESC:Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex Gene:TSC3(YBR058C-A)|FD-Score:5.26|P-value:7.03E-8||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:TUB3(YML124C)|FD-Score:3.34|P-value:4.20E-4||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication Gene:TWF1(YGR080W)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly Gene:YBP2(YGL060W)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication Gene:YBR196C-A(YBR196C-A_p)|FD-Score:3.51|P-value:2.27E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR514C(YDR514C)|FD-Score:3.88|P-value:5.18E-5||SGD DESC:Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication Gene:YHR050W-A(YHR050W-A_p)|FD-Score:3.68|P-value:1.19E-4||SGD DESC:Protein of unknown function; identified by expression profiling and mass spectrometry Gene:YKR033C(YKR033C_d)|FD-Score:3.24|P-value:6.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80 Gene:YLR269C(YLR269C_d)|FD-Score:3.87|P-value:5.35E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YML053C(YML053C_p)|FD-Score:4.46|P-value:4.06E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene Gene:YML101C-A(YML101C-A_d)|FD-Score:3.98|P-value:3.40E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR141C(YMR141C_d)|FD-Score:3.16|P-value:8.00E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOL073C(YOL073C_p)|FD-Score:3.53|P-value:2.09E-4||SGD DESC:Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2 Gene:YOR277C(YOR277C_d)|FD-Score:3.66|P-value:1.25E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 Gene:YPK1(YKL126W)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication Gene:YPR027C(YPR027C_p)|FD-Score:3.65|P-value:1.30E-4||SGD DESC:Putative protein of unknown function Gene:YPR109W(YPR109W_p)|FD-Score:4.4|P-value:5.43E-6||SGD DESC:Predicted membrane protein; dipoid deletion strain has high budding index Gene:YVH1(YIR026C)|FD-Score:-3.89|P-value:4.97E-5||SGD DESC:Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YMR208W5.521.65E-80.56ERG12Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YLR105C5.247.94E-80.56SEN2Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
YER003C4.779.15E-70.56PMI40Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YKL042W4.211.26E-50.47SPC42Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
YIR010W3.749.04E-50.01DSN1Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
YKL182W3.749.23E-50.18FAS1Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YFL037W3.551.89E-40.18TUB2Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
YJR123W3.373.77E-40.12RPS5Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7
YGL112C3.255.85E-40.09TAF6Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
YDL058W3.167.89E-40.01USO1Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
YKR022C3.158.08E-40.02NTR2Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
YLR298C3.138.64E-40.19YHC1Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
YDR324C2.940.001630.01UTP4Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
YLR076C_d2.930.001690.18YLR076C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
YPR181C2.760.002930.04SEC23GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YER007W5.842.60E-9PAC2Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
YBR058C-A5.267.03E-8TSC3Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
YLR142W4.924.22E-7PUT1Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YMR251W4.681.44E-6GTO3Omega class glutathione transferase; putative cytosolic localization
YLR019W4.651.62E-6PSR2Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
YML053C_p4.464.06E-6YML053C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
YDR334W4.454.30E-6SWR1Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YPR109W_p4.405.43E-6YPR109W_pPredicted membrane protein; dipoid deletion strain has high budding index
YHL020C4.356.88E-6OPI1Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance
YDR345C4.251.08E-5HXT3Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication
YML101C-A_d3.983.40E-5YML101C-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL229C3.895.10E-5SAP4Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
YDR514C3.885.18E-5YDR514CProtein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication
YLR269C_d3.875.35E-5YLR269C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL036W3.778.06E-5RPO41Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation

GO enrichment analysis for SGTC_2098
No biological processes are significantly enriched (FDR < 0.1).

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1847.47E-46SGTC_2103551-0445 56.8 μMChemDiv (Drug-like library)28651800.197183
0.1824.92E-45SGTC_8971000-0139 31.4 μMChemDiv (Drug-like library)61510200.114754
0.1721.29E-40SGTC_229benomyl 22.9 μMMiscellaneous287800.0958904tubulin folding & SWR complex
0.1681.88E-38SGTC_23236148992 148.3 μMChembridge (Fragment library)28882200.107692
0.1602.44E-35SGTC_21415621638 7.7 μMChembridge (Fragment library)28562380.688889tubulin folding & SWR complex
0.1561.38E-33SGTC_2123807-4682 38.8 μMChemDiv (Drug-like library)31255010.176471tubulin folding & SWR complex
0.1561.75E-33SGTC_23196033012 152.6 μMChembridge (Fragment library)8472460.0952381tubulin folding & SWR complex
0.1554.57E-33SGTC_5891227-0070 34.1 μMChemDiv (Drug-like library)28413840.290909
0.1554.94E-33SGTC_20905301565 104.4 μMChembridge (Fragment library)20563440.0793651TSC3-RPN4
0.1541.08E-32SGTC_33179138495 8.8 μMChembridge (Drug-like library)170201390.123288
0.1526.38E-32SGTC_22006600604 21.9 μMChembridge (Fragment library)29047770.326531tubulin folding & SWR complex
0.1511.36E-31SGTC_32829108498 15.5 μMChembridge (Drug-like library)164596450.136986
0.1462.18E-29SGTC_20925303694 80.7 μMChembridge (Fragment library)19636990.0806452TSC3-RPN4
0.1453.04E-29SGTC_32369132701 49.5 μMChembridge (Drug-like library)242825240.183099TSC3-RPN4
0.1447.58E-29SGTC_21105483698 200.0 μMChembridge (Fragment library)28487650.046875TSC3-RPN4

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_214156216387.67 μM0.6888892856238Chembridge (Fragment library)289.713681.71303tubulin folding & SWR complex
SGTC_1493970-082246.1 μM0.6530613114250ChemDiv (Drug-like library)313.347761.90504tubulin folding & SWR complex
SGTC_2103537813810 μM0.512195244142Chembridge (Fragment library)241.242040.84403
SGTC_3773970-096433.1 μM0.44262316481235ChemDiv (Drug-like library)413.377460.31908
SGTC_3793970-09725.9 μM0.4354842898042ChemDiv (Drug-like library)401.366760.56208tubulin folding & SWR complex
SGTC_1593970-095950 μM0.426236615653ChemDiv (Drug-like library)429.376860.43409
SGTC_3783970-09598.33 μM0.426236615653ChemDiv (Drug-like library)429.376860.43409
SGTC_3753970-09619.27 μM0.4218752898222ChemDiv (Drug-like library)439.338751.521010tubulin folding & SWR complex
SGTC_3803970-09686 μM0.4153852891601ChemDiv (Drug-like library)416.338340.47309
SGTC_2144373-349670 μM0.4029853779166ChemDiv (Drug-like library)443.403440.78309
SGTC_6383970-08374.09 μM0.3962264118451ChemDiv (Drug-like library)337.293172.19606