Deletion Strain | FD score | P-value | Gene | Gene Description |
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YJR103W | 7.86 | 1.86E-15 | URA8 | Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication |
YBL066C | 5.95 | 1.37E-9 | SEF1 | Putative transcription factor, has homolog in Kluyveromyces lactis |
YDR406W | 5.46 | 2.43E-8 | PDR15 | Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element |
YGL157W | 5.15 | 1.32E-7 | ARI1 | NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily |
YPL119C | 4.85 | 6.17E-7 | DBP1 | Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress |
YMR150C | 4.53 | 2.95E-6 | IMP1 | Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p |
YDR122W | 4.29 | 8.86E-6 | KIN1 | Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p |
YML101C | 4.26 | 1.01E-5 | CUE4 | Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication |
YKL087C | 4.23 | 1.18E-5 | CYT2 | Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 |
YCR016W_p | 4.22 | 1.22E-5 | YCR016W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis |
YKL166C | 4.19 | 1.40E-5 | TPK3 | cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication |
YFL011W | 4.13 | 1.81E-5 | HXT10 | Putative hexose transporter, expressed at low levels and expression is repressed by glucose |
YLR353W | 4.07 | 2.37E-5 | BUD8 | Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole |
YMR032W | 4.04 | 2.62E-5 | HOF1 | Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p |
YLL038C | 4.00 | 3.11E-5 | ENT4 | Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome |