5378138

2-phenyl-3a,4,7,7a-tetrahydro-octahydro-1H-4,7-epoxyisoindole-1,3-dione

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2103
Screen concentration 10.0 μM
Source Chembridge (Fragment library)
PubChem CID 244142
SMILES C1=CC=C(C=C1)N2C(=O)C3C4C=CC(C3C2=O)O4
Standardized SMILES O=C1C2C3OC(C=C3)C2C(=O)N1c4ccccc4
Molecular weight 241.242
ALogP 0.84
H-bond donor count 0
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) -0.2
% growth inhibition (Hom. pool) -1.33


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 244142
Download HIP data (tab-delimited text)  (excel)
Gene:ASK1(YKL052C)|FD-Score:3.11|P-value:9.33E-4|Clearance:0.03||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress Gene:CEG1(YGL130W)|FD-Score:4.66|P-value:1.59E-6|Clearance:0.92||SGD DESC:Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide Gene:COF1(YLL050C)|FD-Score:3.24|P-value:6.04E-4|Clearance:0.03||SGD DESC:Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes Gene:HSP60(YLR259C)|FD-Score:3.42|P-value:3.17E-4|Clearance:0.18||SGD DESC:Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated Gene:NDC1(YML031W)|FD-Score:3.2|P-value:6.84E-4|Clearance:0.05||SGD DESC:Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1 Gene:RPA135(YPR010C)|FD-Score:3.21|P-value:6.71E-4|Clearance:0.01||SGD DESC:RNA polymerase I second largest subunit A135 Gene:RPA43(YOR340C)|FD-Score:-3.43|P-value:3.06E-4|Clearance:0||SGD DESC:RNA polymerase I subunit A43 Gene:YAL034C-B(YAL034C-B_d)|FD-Score:3.74|P-value:9.12E-5|Clearance:0.25||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YJL086C(YJL086C_d)|FD-Score:-3.86|P-value:5.74E-5|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 Gene:YLR140W(YLR140W_d)|FD-Score:3.49|P-value:2.40E-4|Clearance:0.07||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I Gene:YPD1(YDL235C)|FD-Score:-4.22|P-value:1.21E-5|Clearance:0||SGD DESC:Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus Gene:YPP1(YGR198W)|FD-Score:3.15|P-value:8.09E-4|Clearance:0.04||SGD DESC:Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene Gene:ASK1(YKL052C)|FD-Score:3.11|P-value:9.33E-4|Clearance:0.03||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress Gene:CEG1(YGL130W)|FD-Score:4.66|P-value:1.59E-6|Clearance:0.92||SGD DESC:Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide Gene:COF1(YLL050C)|FD-Score:3.24|P-value:6.04E-4|Clearance:0.03||SGD DESC:Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes Gene:HSP60(YLR259C)|FD-Score:3.42|P-value:3.17E-4|Clearance:0.18||SGD DESC:Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated Gene:NDC1(YML031W)|FD-Score:3.2|P-value:6.84E-4|Clearance:0.05||SGD DESC:Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1 Gene:RPA135(YPR010C)|FD-Score:3.21|P-value:6.71E-4|Clearance:0.01||SGD DESC:RNA polymerase I second largest subunit A135 Gene:RPA43(YOR340C)|FD-Score:-3.43|P-value:3.06E-4|Clearance:0||SGD DESC:RNA polymerase I subunit A43 Gene:YAL034C-B(YAL034C-B_d)|FD-Score:3.74|P-value:9.12E-5|Clearance:0.25||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YJL086C(YJL086C_d)|FD-Score:-3.86|P-value:5.74E-5|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 Gene:YLR140W(YLR140W_d)|FD-Score:3.49|P-value:2.40E-4|Clearance:0.07||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I Gene:YPD1(YDL235C)|FD-Score:-4.22|P-value:1.21E-5|Clearance:0||SGD DESC:Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus Gene:YPP1(YGR198W)|FD-Score:3.15|P-value:8.09E-4|Clearance:0.04||SGD DESC:Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 244142
Download HOP data (tab-delimited text)  (excel)
Gene:AAC3(YBR085W)|FD-Score:3.21|P-value:6.54E-4||SGD DESC:Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication Gene:ACH1(YBL015W)|FD-Score:3.13|P-value:8.74E-4||SGD DESC:Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth Gene:AKR1(YDR264C)|FD-Score:3.25|P-value:5.77E-4||SGD DESC:Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication Gene:ARI1(YGL157W)|FD-Score:5.15|P-value:1.32E-7||SGD DESC:NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily Gene:BDH1(YAL060W)|FD-Score:3.85|P-value:5.81E-5||SGD DESC:NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source Gene:BUD8(YLR353W)|FD-Score:4.07|P-value:2.37E-5||SGD DESC:Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole Gene:CHZ1(YER030W)|FD-Score:3.16|P-value:8.01E-4||SGD DESC:Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress Gene:COA6(YMR244C-A_p)|FD-Score:3.36|P-value:3.91E-4||SGD DESC:Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress Gene:CUE4(YML101C)|FD-Score:4.26|P-value:1.01E-5||SGD DESC:Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication Gene:CYT2(YKL087C)|FD-Score:4.23|P-value:1.18E-5||SGD DESC:Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 Gene:DBP1(YPL119C)|FD-Score:4.85|P-value:6.17E-7||SGD DESC:Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress Gene:DIT1(YDR403W)|FD-Score:3.41|P-value:3.28E-4||SGD DESC:Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure Gene:EAF3(YPR023C)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition Gene:ENT4(YLL038C)|FD-Score:4|P-value:3.11E-5||SGD DESC:Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome Gene:FOB1(YDR110W)|FD-Score:3.39|P-value:3.51E-4||SGD DESC:Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases Gene:FPR3(YML074C)|FD-Score:3.87|P-value:5.39E-5||SGD DESC:Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p Gene:FTH1(YBR207W)|FD-Score:3.79|P-value:7.58E-5||SGD DESC:Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress Gene:GPD1(YDL022W)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity Gene:HOF1(YMR032W)|FD-Score:4.04|P-value:2.62E-5||SGD DESC:Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p Gene:HXT10(YFL011W)|FD-Score:4.13|P-value:1.81E-5||SGD DESC:Putative hexose transporter, expressed at low levels and expression is repressed by glucose Gene:IMP1(YMR150C)|FD-Score:4.53|P-value:2.95E-6||SGD DESC:Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p Gene:KIN1(YDR122W)|FD-Score:4.29|P-value:8.86E-6||SGD DESC:Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p Gene:MAD1(YGL086W)|FD-Score:3.18|P-value:7.24E-4||SGD DESC:Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p Gene:MAM33(YIL070C)|FD-Score:-3.2|P-value:6.77E-4||SGD DESC:Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R Gene:MCH2(YKL221W)|FD-Score:-3.52|P-value:2.19E-4||SGD DESC:Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport Gene:MCX1(YBR227C)|FD-Score:-3.22|P-value:6.48E-4||SGD DESC:Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins Gene:MRP20(YDR405W)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MUD2(YKL074C)|FD-Score:3.1|P-value:9.61E-4||SGD DESC:Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65 Gene:MUP1(YGR055W)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake Gene:NNK1(YKL171W)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm Gene:NUP188(YML103C)|FD-Score:3.23|P-value:6.23E-4||SGD DESC:Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188 Gene:PDR15(YDR406W)|FD-Score:5.46|P-value:2.43E-8||SGD DESC:Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element Gene:PML1(YLR016C)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p Gene:PUT1(YLR142W)|FD-Score:3.16|P-value:7.87E-4||SGD DESC:Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source Gene:RIM11(YMR139W)|FD-Score:3.64|P-value:1.36E-4||SGD DESC:Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress Gene:RPL31B(YLR406C)|FD-Score:-3.18|P-value:7.25E-4||SGD DESC:Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication Gene:RUB1(YDR139C)|FD-Score:3.31|P-value:4.68E-4||SGD DESC:Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme) Gene:SEF1(YBL066C)|FD-Score:5.95|P-value:1.37E-9||SGD DESC:Putative transcription factor, has homolog in Kluyveromyces lactis Gene:SFK1(YKL051W)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane Gene:SHE4(YOR035C)|FD-Score:3.18|P-value:7.46E-4||SGD DESC:Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization Gene:SPC2(YML055W)|FD-Score:-3.35|P-value:4.05E-4||SGD DESC:Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 Gene:SPO16(YHR153C)|FD-Score:3.26|P-value:5.62E-4||SGD DESC:Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation Gene:STP2(YHR006W)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication Gene:TIF2(YJL138C)|FD-Score:3.12|P-value:9.05E-4||SGD DESC:Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication Gene:TMA17(YDL110C)|FD-Score:3.48|P-value:2.54E-4||SGD DESC:Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion Gene:TPK3(YKL166C)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication Gene:TSL1(YML100W)|FD-Score:3.53|P-value:2.10E-4||SGD DESC:Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication Gene:URA8(YJR103W)|FD-Score:7.86|P-value:1.86E-15||SGD DESC:Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication Gene:VTH1(YIL173W)|FD-Score:3.71|P-value:1.04E-4||SGD DESC:Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting Gene:YCL076W(YCL076W_d)|FD-Score:3.2|P-value:6.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YCR016W(YCR016W_p)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis Gene:YFL063W(YFL063W_d)|FD-Score:3.89|P-value:5.08E-5||SGD DESC:Dubious open reading frame, based on available experimental and comparative sequence data Gene:YFR018C(YFR018C_p)|FD-Score:3.53|P-value:2.06E-4||SGD DESC:Putative protein of unknown function Gene:YJR129C(YJR129C_p)|FD-Score:3.76|P-value:8.39E-5||SGD DESC:Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YKL131W(YKL131W_d)|FD-Score:3.93|P-value:4.19E-5||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YML083C(YML083C_p)|FD-Score:3.3|P-value:4.91E-4||SGD DESC:Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions Gene:YMR007W(YMR007W_d)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL011C(YNL011C_p)|FD-Score:3.2|P-value:6.81E-4||SGD DESC:Putative protein of unknown function; YNL011C is not an essential gene Gene:ZRG17(YNR039C)|FD-Score:3.36|P-value:3.86E-4||SGD DESC:Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency Gene:AAC3(YBR085W)|FD-Score:3.21|P-value:6.54E-4||SGD DESC:Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication Gene:ACH1(YBL015W)|FD-Score:3.13|P-value:8.74E-4||SGD DESC:Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth Gene:AKR1(YDR264C)|FD-Score:3.25|P-value:5.77E-4||SGD DESC:Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication Gene:ARI1(YGL157W)|FD-Score:5.15|P-value:1.32E-7||SGD DESC:NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily Gene:BDH1(YAL060W)|FD-Score:3.85|P-value:5.81E-5||SGD DESC:NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source Gene:BUD8(YLR353W)|FD-Score:4.07|P-value:2.37E-5||SGD DESC:Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole Gene:CHZ1(YER030W)|FD-Score:3.16|P-value:8.01E-4||SGD DESC:Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress Gene:COA6(YMR244C-A_p)|FD-Score:3.36|P-value:3.91E-4||SGD DESC:Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress Gene:CUE4(YML101C)|FD-Score:4.26|P-value:1.01E-5||SGD DESC:Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication Gene:CYT2(YKL087C)|FD-Score:4.23|P-value:1.18E-5||SGD DESC:Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 Gene:DBP1(YPL119C)|FD-Score:4.85|P-value:6.17E-7||SGD DESC:Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress Gene:DIT1(YDR403W)|FD-Score:3.41|P-value:3.28E-4||SGD DESC:Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure Gene:EAF3(YPR023C)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition Gene:ENT4(YLL038C)|FD-Score:4|P-value:3.11E-5||SGD DESC:Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome Gene:FOB1(YDR110W)|FD-Score:3.39|P-value:3.51E-4||SGD DESC:Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases Gene:FPR3(YML074C)|FD-Score:3.87|P-value:5.39E-5||SGD DESC:Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p Gene:FTH1(YBR207W)|FD-Score:3.79|P-value:7.58E-5||SGD DESC:Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress Gene:GPD1(YDL022W)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity Gene:HOF1(YMR032W)|FD-Score:4.04|P-value:2.62E-5||SGD DESC:Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p Gene:HXT10(YFL011W)|FD-Score:4.13|P-value:1.81E-5||SGD DESC:Putative hexose transporter, expressed at low levels and expression is repressed by glucose Gene:IMP1(YMR150C)|FD-Score:4.53|P-value:2.95E-6||SGD DESC:Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p Gene:KIN1(YDR122W)|FD-Score:4.29|P-value:8.86E-6||SGD DESC:Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p Gene:MAD1(YGL086W)|FD-Score:3.18|P-value:7.24E-4||SGD DESC:Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p Gene:MAM33(YIL070C)|FD-Score:-3.2|P-value:6.77E-4||SGD DESC:Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R Gene:MCH2(YKL221W)|FD-Score:-3.52|P-value:2.19E-4||SGD DESC:Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport Gene:MCX1(YBR227C)|FD-Score:-3.22|P-value:6.48E-4||SGD DESC:Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins Gene:MRP20(YDR405W)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MUD2(YKL074C)|FD-Score:3.1|P-value:9.61E-4||SGD DESC:Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65 Gene:MUP1(YGR055W)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake Gene:NNK1(YKL171W)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm Gene:NUP188(YML103C)|FD-Score:3.23|P-value:6.23E-4||SGD DESC:Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188 Gene:PDR15(YDR406W)|FD-Score:5.46|P-value:2.43E-8||SGD DESC:Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element Gene:PML1(YLR016C)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p Gene:PUT1(YLR142W)|FD-Score:3.16|P-value:7.87E-4||SGD DESC:Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source Gene:RIM11(YMR139W)|FD-Score:3.64|P-value:1.36E-4||SGD DESC:Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress Gene:RPL31B(YLR406C)|FD-Score:-3.18|P-value:7.25E-4||SGD DESC:Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication Gene:RUB1(YDR139C)|FD-Score:3.31|P-value:4.68E-4||SGD DESC:Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme) Gene:SEF1(YBL066C)|FD-Score:5.95|P-value:1.37E-9||SGD DESC:Putative transcription factor, has homolog in Kluyveromyces lactis Gene:SFK1(YKL051W)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane Gene:SHE4(YOR035C)|FD-Score:3.18|P-value:7.46E-4||SGD DESC:Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization Gene:SPC2(YML055W)|FD-Score:-3.35|P-value:4.05E-4||SGD DESC:Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 Gene:SPO16(YHR153C)|FD-Score:3.26|P-value:5.62E-4||SGD DESC:Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation Gene:STP2(YHR006W)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication Gene:TIF2(YJL138C)|FD-Score:3.12|P-value:9.05E-4||SGD DESC:Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication Gene:TMA17(YDL110C)|FD-Score:3.48|P-value:2.54E-4||SGD DESC:Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion Gene:TPK3(YKL166C)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication Gene:TSL1(YML100W)|FD-Score:3.53|P-value:2.10E-4||SGD DESC:Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication Gene:URA8(YJR103W)|FD-Score:7.86|P-value:1.86E-15||SGD DESC:Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication Gene:VTH1(YIL173W)|FD-Score:3.71|P-value:1.04E-4||SGD DESC:Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting Gene:YCL076W(YCL076W_d)|FD-Score:3.2|P-value:6.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YCR016W(YCR016W_p)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis Gene:YFL063W(YFL063W_d)|FD-Score:3.89|P-value:5.08E-5||SGD DESC:Dubious open reading frame, based on available experimental and comparative sequence data Gene:YFR018C(YFR018C_p)|FD-Score:3.53|P-value:2.06E-4||SGD DESC:Putative protein of unknown function Gene:YJR129C(YJR129C_p)|FD-Score:3.76|P-value:8.39E-5||SGD DESC:Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YKL131W(YKL131W_d)|FD-Score:3.93|P-value:4.19E-5||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YML083C(YML083C_p)|FD-Score:3.3|P-value:4.91E-4||SGD DESC:Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions Gene:YMR007W(YMR007W_d)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL011C(YNL011C_p)|FD-Score:3.2|P-value:6.81E-4||SGD DESC:Putative protein of unknown function; YNL011C is not an essential gene Gene:ZRG17(YNR039C)|FD-Score:3.36|P-value:3.86E-4||SGD DESC:Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL130W4.661.59E-60.92CEG1Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
YAL034C-B_d3.749.12E-50.25YAL034C-B_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR140W_d3.492.40E-40.07YLR140W_dDubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I
YLR259C3.423.17E-40.18HSP60Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YLL050C3.246.04E-40.03COF1Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
YPR010C3.216.71E-40.01RPA135RNA polymerase I second largest subunit A135
YML031W3.206.84E-40.05NDC1Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
YGR198W3.158.09E-40.04YPP1Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
YKL052C3.119.33E-40.03ASK1Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress
YMR149W3.080.001020.01SWP1Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
YDR407C3.070.001060.04TRS120One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YMR277W3.040.001200.07FCP1Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
YNL261W2.960.001520.00ORC5Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
YPR041W2.960.001540.04TIF5Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2
YGL008C2.920.001730.04PMA1Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YJR103W7.861.86E-15URA8Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication
YBL066C5.951.37E-9SEF1Putative transcription factor, has homolog in Kluyveromyces lactis
YDR406W5.462.43E-8PDR15Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YGL157W5.151.32E-7ARI1NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily
YPL119C4.856.17E-7DBP1Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress
YMR150C4.532.95E-6IMP1Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
YDR122W4.298.86E-6KIN1Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
YML101C4.261.01E-5CUE4Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
YKL087C4.231.18E-5CYT2Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
YCR016W_p4.221.22E-5YCR016W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis
YKL166C4.191.40E-5TPK3cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
YFL011W4.131.81E-5HXT10Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YLR353W4.072.37E-5BUD8Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
YMR032W4.042.62E-5HOF1Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YLL038C4.003.11E-5ENT4Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome

GO enrichment analysis for SGTC_2103
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1224.28E-21SGTC_2693st077581 40.7 μMTimTec (Natural product derivative library)252387610.091954
0.0757.14E-9SGTC_2608thymoquinone 42.7 μMMicrosource (Natural product library)102810.0952381
0.0681.99E-7SGTC_326k292-0812 17.5 μMChemDiv (Drug-like library)35793570.0810811
0.0655.60E-7SGTC_2602kawain 100.0 μMMicrosource (Natural product library)53691290.192308
0.0631.08E-6SGTC_20965468907 200.0 μMChembridge (Fragment library)7597850.0701754
0.0613.12E-6SGTC_28769059903 26.0 μMChembridge (Drug-like library)69160950.12069
0.0604.38E-6SGTC_219mitoxanthrone 164.4 μMMiscellaneous42120.0961538DNA intercalators
0.0596.70E-6SGTC_1906st060206 94.7 μMTimTec (Natural product derivative library)51334680.156863
0.0561.70E-5SGTC_12700831-1170 17.3 μMChemDiv (Drug-like library)67647160.118644
0.0543.83E-5SGTC_10593448-6867 171.0 μMChemDiv (Drug-like library)39344070.146667
0.0501.40E-4SGTC_393acivicin 6.2 μMMiscellaneous167581750.0784314
0.0491.42E-4SGTC_32979117502 71.4 μMChembridge (Drug-like library)74537200.0634921
0.0491.50E-4SGTC_23165844804 197.4 μMChembridge (Fragment library)7768130.0892857
0.0491.76E-4SGTC_21075363541 170.2 μMChembridge (Fragment library)2440520.0769231
0.0482.40E-4SGTC_2415st077333 57.7 μMTimTec (Natural product derivative library)27662550.134328

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_14863970-07934.53 μM0.68752844330ChemDiv (Drug-like library)320.13811.59203
SGTC_14873970-07952.82 μM0.6571433765103ChemDiv (Drug-like library)320.13811.59203DNA intercalators
SGTC_1903970-07903.72 μM0.6111112832352ChemDiv (Drug-like library)286.23960.73805
SGTC_216156625048.51 μM0.62859334Chembridge (Fragment library)275.68711.50803tubulin folding & SWR complex
SGTC_215856571233.62 μM0.5833332858827Chembridge (Fragment library)269.29521.81603
SGTC_2200660060421.91 μM0.5714292904777Chembridge (Fragment library)269.29521.81603tubulin folding & SWR complex
SGTC_9963970-07991.8 μM0.556615648ChemDiv (Drug-like library)299.321181.704
SGTC_21735763948167 μM0.5263162867177Chembridge (Fragment library)269.29521.81603tubulin folding & SWR complex
SGTC_20985376439882.5 nM0.5121952844116Chembridge (Fragment library)255.268621.04903
SGTC_12790874-059065.2 μM0.3333333523074ChemDiv (Drug-like library)410.260643.99503