Deletion Strain | FD score | P-value | Gene | Gene Description |
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YMR253C_p | 7.30 | 1.41E-13 | YMR253C_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene |
YEL067C_p | 7.02 | 1.10E-12 | YEL067C_p | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YCR037C | 6.90 | 2.58E-12 | PHO87 | Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication |
YBR047W_p | 4.94 | 3.99E-7 | FMP23_p | Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YNR057C | 4.54 | 2.78E-6 | BIO4 | Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels |
YKL048C | 4.37 | 6.10E-6 | ELM1 | Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring |
YKL011C | 4.28 | 9.15E-6 | CCE1 | Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA |
YKL216W | 4.24 | 1.13E-5 | URA1 | Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid |
YMR078C | 4.21 | 1.26E-5 | CTF18 | Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint |
YPR124W | 4.19 | 1.37E-5 | CTR1 | High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress |
YMR021C | 4.10 | 2.03E-5 | MAC1 | Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport |
YGL041C_d | 4.10 | 2.11E-5 | YGL041C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YBR278W | 4.01 | 3.01E-5 | DPB3 | Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication |
YOL070C | 3.97 | 3.65E-5 | NBA1 | Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate |
YGL021W | 3.95 | 3.93E-5 | ALK1 | Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins |