Deletion Strain | FD score | P-value | Gene | Gene Description |
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YJL110C | 10.10 | 3.00E-24 | GZF3 | GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication |
YLR384C | 7.73 | 5.43E-15 | IKI3 | Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) |
YLR373C | 7.35 | 9.72E-14 | VID22 | Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles |
YBR246W | 7.17 | 3.80E-13 | RRT2 | Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription |
YBR026C | 6.69 | 1.09E-11 | ETR1 | 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis |
YCL045C | 5.75 | 4.55E-9 | EMC1 | Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090 |
YIL009C-A | 5.68 | 6.58E-9 | EST3 | Component of the telomerase holoenzyme, involved in telomere replication |
YFR045W_p | 5.65 | 7.93E-9 | YFR045W_p | Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white |
YNL212W | 5.31 | 5.50E-8 | VID27 | Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth |
YOR042W | 5.08 | 1.93E-7 | CUE5 | Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
YOL116W | 4.83 | 6.69E-7 | MSN1 | Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress |
YDR537C_d | 4.75 | 1.04E-6 | YDR537C_d | Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W |
YIL014W | 4.73 | 1.11E-6 | MNT3 | Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation |
YPR135W | 4.65 | 1.64E-6 | CTF4 | Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion |
YGL015C_p | 4.57 | 2.46E-6 | YGL015C_p | Putative protein of unknown function; null mutants accumulate cargo in the Golgi |