5363541

2-(4-chloro-3-methylphenoxy)acetamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2107
Screen concentration 170.2 μM
Source Chembridge (Fragment library)
PubChem CID 244052
SMILES CC1=C(C=CC(=C1)OCC(=O)N)Cl
Standardized SMILES Cc1cc(OCC(=O)N)ccc1Cl
Molecular weight 199.6342
ALogP 1.82
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 21.74
% growth inhibition (Hom. pool) 5.35


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 244052
Download HIP data (tab-delimited text)  (excel)
Gene:ACC1(YNR016C)|FD-Score:4.49|P-value:3.64E-6|Clearance:0.22||SGD DESC:Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; Gene:CDC6(YJL194W)|FD-Score:-3.29|P-value:5.02E-4|Clearance:0||SGD DESC:Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:DFR1(YOR236W)|FD-Score:4.86|P-value:5.87E-7|Clearance:0.32||SGD DESC:Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism Gene:MED7(YOL135C)|FD-Score:4|P-value:3.14E-5|Clearance:0.21||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:MEX67(YPL169C)|FD-Score:3.69|P-value:1.13E-4|Clearance:0.07||SGD DESC:Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP Gene:MRPS18(YNL306W)|FD-Score:3.52|P-value:2.17E-4|Clearance:0||SGD DESC:Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins Gene:NOP8(YOL144W)|FD-Score:3.36|P-value:3.95E-4|Clearance:0.04||SGD DESC:Nucleolar protein required for 60S ribosomal subunit biogenesis Gene:NUP49(YGL172W)|FD-Score:5.12|P-value:1.49E-7|Clearance:0.32||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) Gene:NUP57(YGR119C)|FD-Score:3.62|P-value:1.46E-4|Clearance:0.1||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) Gene:POP7(YBR167C)|FD-Score:3.52|P-value:2.19E-4|Clearance:0.16||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:PRE6(YOL038W)|FD-Score:4.06|P-value:2.51E-5|Clearance:0.05||SGD DESC:Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress Gene:RHO1(YPR165W)|FD-Score:3.2|P-value:6.76E-4|Clearance:0.14||SGD DESC:GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) Gene:RPP1(YHR062C)|FD-Score:3.79|P-value:7.40E-5|Clearance:0.11||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:RSC58(YLR033W)|FD-Score:4.81|P-value:7.65E-7|Clearance:0.32||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:RSC9(YML127W)|FD-Score:4.26|P-value:1.02E-5|Clearance:0.21||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:SEC31(YDL195W)|FD-Score:-3.11|P-value:9.28E-4|Clearance:0||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:TBF1(YPL128C)|FD-Score:3.32|P-value:4.55E-4|Clearance:0.01||SGD DESC:Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation Gene:YIP1(YGR172C)|FD-Score:3.23|P-value:6.15E-4|Clearance:0.03||SGD DESC:Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4 Gene:YMR290W-A(YMR290W-A_d)|FD-Score:3.3|P-value:4.77E-4|Clearance:0.07||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase Gene:ACC1(YNR016C)|FD-Score:4.49|P-value:3.64E-6|Clearance:0.22||SGD DESC:Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; Gene:CDC6(YJL194W)|FD-Score:-3.29|P-value:5.02E-4|Clearance:0||SGD DESC:Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:DFR1(YOR236W)|FD-Score:4.86|P-value:5.87E-7|Clearance:0.32||SGD DESC:Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism Gene:MED7(YOL135C)|FD-Score:4|P-value:3.14E-5|Clearance:0.21||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:MEX67(YPL169C)|FD-Score:3.69|P-value:1.13E-4|Clearance:0.07||SGD DESC:Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP Gene:MRPS18(YNL306W)|FD-Score:3.52|P-value:2.17E-4|Clearance:0||SGD DESC:Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins Gene:NOP8(YOL144W)|FD-Score:3.36|P-value:3.95E-4|Clearance:0.04||SGD DESC:Nucleolar protein required for 60S ribosomal subunit biogenesis Gene:NUP49(YGL172W)|FD-Score:5.12|P-value:1.49E-7|Clearance:0.32||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) Gene:NUP57(YGR119C)|FD-Score:3.62|P-value:1.46E-4|Clearance:0.1||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) Gene:POP7(YBR167C)|FD-Score:3.52|P-value:2.19E-4|Clearance:0.16||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:PRE6(YOL038W)|FD-Score:4.06|P-value:2.51E-5|Clearance:0.05||SGD DESC:Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress Gene:RHO1(YPR165W)|FD-Score:3.2|P-value:6.76E-4|Clearance:0.14||SGD DESC:GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) Gene:RPP1(YHR062C)|FD-Score:3.79|P-value:7.40E-5|Clearance:0.11||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:RSC58(YLR033W)|FD-Score:4.81|P-value:7.65E-7|Clearance:0.32||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:RSC9(YML127W)|FD-Score:4.26|P-value:1.02E-5|Clearance:0.21||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:SEC31(YDL195W)|FD-Score:-3.11|P-value:9.28E-4|Clearance:0||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:TBF1(YPL128C)|FD-Score:3.32|P-value:4.55E-4|Clearance:0.01||SGD DESC:Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation Gene:YIP1(YGR172C)|FD-Score:3.23|P-value:6.15E-4|Clearance:0.03||SGD DESC:Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4 Gene:YMR290W-A(YMR290W-A_d)|FD-Score:3.3|P-value:4.77E-4|Clearance:0.07||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 244052
Download HOP data (tab-delimited text)  (excel)
Gene:ADE12(YNL220W)|FD-Score:3.16|P-value:7.85E-4||SGD DESC:Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence Gene:ATP18(YML081C-A)|FD-Score:3.9|P-value:4.84E-5||SGD DESC:Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms Gene:ATP19(YOL077W-A)|FD-Score:3.18|P-value:7.45E-4||SGD DESC:Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase Gene:BTS1(YPL069C)|FD-Score:-3.41|P-value:3.25E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CHO2(YGR157W)|FD-Score:-3.67|P-value:1.23E-4||SGD DESC:Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis Gene:CLD1(YGR110W)|FD-Score:-3.62|P-value:1.49E-4||SGD DESC:Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 Gene:CUE2(YKL090W)|FD-Score:-3.97|P-value:3.54E-5||SGD DESC:Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination Gene:DSD1(YGL196W)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate Gene:EAF3(YPR023C)|FD-Score:3.12|P-value:9.10E-4||SGD DESC:Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition Gene:EMP70(YLR083C)|FD-Score:-3.53|P-value:2.09E-4||SGD DESC:Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments Gene:FTH1(YBR207W)|FD-Score:4.26|P-value:1.01E-5||SGD DESC:Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress Gene:FYV5(YCL058C)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis Gene:GZF3(YJL110C)|FD-Score:-5.09|P-value:1.79E-7||SGD DESC:GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication Gene:IME1(YJR094C)|FD-Score:3.79|P-value:7.64E-5||SGD DESC:Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p Gene:IRC19(YLL033W)|FD-Score:3.41|P-value:3.30E-4||SGD DESC:Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci Gene:KTR3(YBR205W)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress Gene:MET13(YGL125W)|FD-Score:-3.89|P-value:4.94E-5||SGD DESC:Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway Gene:MIP1(YOR330C)|FD-Score:3.17|P-value:7.75E-4||SGD DESC:Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit Gene:MRPL15(YLR312W-A)|FD-Score:3.42|P-value:3.14E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:PDR8(YLR266C)|FD-Score:3.11|P-value:9.23E-4||SGD DESC:Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication Gene:PEX12(YMR026C)|FD-Score:-5.82|P-value:3.03E-9||SGD DESC:C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder Gene:PPG1(YNR032W)|FD-Score:-3.31|P-value:4.70E-4||SGD DESC:Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases Gene:PPN1(YDR452W)|FD-Score:-3.59|P-value:1.64E-4||SGD DESC:Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:RAD24(YER173W)|FD-Score:-3.35|P-value:4.03E-4||SGD DESC:Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein Gene:RDL1(YOR285W)|FD-Score:5.14|P-value:1.39E-7||SGD DESC:Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress Gene:REH1(YLR387C)|FD-Score:-3.53|P-value:2.04E-4||SGD DESC:Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains Gene:SAM3(YPL274W)|FD-Score:-3.23|P-value:6.25E-4||SGD DESC:High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p Gene:SAN1(YDR143C)|FD-Score:-4.14|P-value:1.77E-5||SGD DESC:Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition Gene:SAP4(YGL229C)|FD-Score:-3.85|P-value:5.80E-5||SGD DESC:Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p Gene:SDP1(YIL113W)|FD-Score:4.42|P-value:5.01E-6||SGD DESC:Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock Gene:TAZ1(YPR140W)|FD-Score:-3.4|P-value:3.38E-4||SGD DESC:Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome Gene:TEF4(YKL081W)|FD-Score:-3.53|P-value:2.04E-4||SGD DESC:Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex Gene:VBA1(YMR088C)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Permease of basic amino acids in the vacuolar membrane Gene:YAL066W(YAL066W_d)|FD-Score:-3.49|P-value:2.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YCL076W(YCL076W_d)|FD-Score:3.65|P-value:1.31E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDL027C(YDL027C_p)|FD-Score:4.78|P-value:8.59E-7||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene Gene:YDL034W(YDL034W_d)|FD-Score:3.84|P-value:6.19E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene Gene:YER188W(YER188W_d)|FD-Score:3.2|P-value:6.93E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Gene:YET2(YMR040W)|FD-Score:-3.31|P-value:4.72E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein Gene:YFL063W(YFL063W_d)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Dubious open reading frame, based on available experimental and comparative sequence data Gene:YFR045W(YFR045W_p)|FD-Score:-3.16|P-value:8.01E-4||SGD DESC:Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white Gene:YGL176C(YGL176C_p)|FD-Score:-3.35|P-value:4.11E-4||SGD DESC:Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype Gene:YJL077W-B(YJL077W-B_p)|FD-Score:-5.13|P-value:1.48E-7||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YKL027W(YKL027W)|FD-Score:-3.38|P-value:3.68E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YLR422W(YLR422W_p)|FD-Score:3.21|P-value:6.75E-4||SGD DESC:Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein Gene:YML101C-A(YML101C-A_d)|FD-Score:3.23|P-value:6.14E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR141C(YMR141C_d)|FD-Score:-3.76|P-value:8.53E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR279C(YMR279C)|FD-Score:-3.18|P-value:7.47E-4||SGD DESC:Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication Gene:YNL295W(YNL295W_p)|FD-Score:3.84|P-value:6.13E-5||SGD DESC:Putative protein of unknown function Gene:YNL324W(YNL324W_d)|FD-Score:4.85|P-value:6.06E-7||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR042W(YNR042W_d)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2 Gene:YOR300W(YOR300W_d)|FD-Score:4.3|P-value:8.42E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 Gene:YPL041C(YPL041C_p)|FD-Score:-3.2|P-value:6.79E-4||SGD DESC:Protein of unknown function involved in maintenance of proper telomere length Gene:YPR159C-A(YPR159C-A_p)|FD-Score:3.5|P-value:2.36E-4||SGD DESC:Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:ADE12(YNL220W)|FD-Score:3.16|P-value:7.85E-4||SGD DESC:Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence Gene:ATP18(YML081C-A)|FD-Score:3.9|P-value:4.84E-5||SGD DESC:Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms Gene:ATP19(YOL077W-A)|FD-Score:3.18|P-value:7.45E-4||SGD DESC:Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase Gene:BTS1(YPL069C)|FD-Score:-3.41|P-value:3.25E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CHO2(YGR157W)|FD-Score:-3.67|P-value:1.23E-4||SGD DESC:Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis Gene:CLD1(YGR110W)|FD-Score:-3.62|P-value:1.49E-4||SGD DESC:Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 Gene:CUE2(YKL090W)|FD-Score:-3.97|P-value:3.54E-5||SGD DESC:Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination Gene:DSD1(YGL196W)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate Gene:EAF3(YPR023C)|FD-Score:3.12|P-value:9.10E-4||SGD DESC:Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition Gene:EMP70(YLR083C)|FD-Score:-3.53|P-value:2.09E-4||SGD DESC:Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments Gene:FTH1(YBR207W)|FD-Score:4.26|P-value:1.01E-5||SGD DESC:Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress Gene:FYV5(YCL058C)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis Gene:GZF3(YJL110C)|FD-Score:-5.09|P-value:1.79E-7||SGD DESC:GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication Gene:IME1(YJR094C)|FD-Score:3.79|P-value:7.64E-5||SGD DESC:Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p Gene:IRC19(YLL033W)|FD-Score:3.41|P-value:3.30E-4||SGD DESC:Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci Gene:KTR3(YBR205W)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress Gene:MET13(YGL125W)|FD-Score:-3.89|P-value:4.94E-5||SGD DESC:Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway Gene:MIP1(YOR330C)|FD-Score:3.17|P-value:7.75E-4||SGD DESC:Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit Gene:MRPL15(YLR312W-A)|FD-Score:3.42|P-value:3.14E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:PDR8(YLR266C)|FD-Score:3.11|P-value:9.23E-4||SGD DESC:Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication Gene:PEX12(YMR026C)|FD-Score:-5.82|P-value:3.03E-9||SGD DESC:C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder Gene:PPG1(YNR032W)|FD-Score:-3.31|P-value:4.70E-4||SGD DESC:Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases Gene:PPN1(YDR452W)|FD-Score:-3.59|P-value:1.64E-4||SGD DESC:Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:RAD24(YER173W)|FD-Score:-3.35|P-value:4.03E-4||SGD DESC:Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein Gene:RDL1(YOR285W)|FD-Score:5.14|P-value:1.39E-7||SGD DESC:Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress Gene:REH1(YLR387C)|FD-Score:-3.53|P-value:2.04E-4||SGD DESC:Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains Gene:SAM3(YPL274W)|FD-Score:-3.23|P-value:6.25E-4||SGD DESC:High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p Gene:SAN1(YDR143C)|FD-Score:-4.14|P-value:1.77E-5||SGD DESC:Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition Gene:SAP4(YGL229C)|FD-Score:-3.85|P-value:5.80E-5||SGD DESC:Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p Gene:SDP1(YIL113W)|FD-Score:4.42|P-value:5.01E-6||SGD DESC:Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock Gene:TAZ1(YPR140W)|FD-Score:-3.4|P-value:3.38E-4||SGD DESC:Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome Gene:TEF4(YKL081W)|FD-Score:-3.53|P-value:2.04E-4||SGD DESC:Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex Gene:VBA1(YMR088C)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Permease of basic amino acids in the vacuolar membrane Gene:YAL066W(YAL066W_d)|FD-Score:-3.49|P-value:2.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YCL076W(YCL076W_d)|FD-Score:3.65|P-value:1.31E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDL027C(YDL027C_p)|FD-Score:4.78|P-value:8.59E-7||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene Gene:YDL034W(YDL034W_d)|FD-Score:3.84|P-value:6.19E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene Gene:YER188W(YER188W_d)|FD-Score:3.2|P-value:6.93E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Gene:YET2(YMR040W)|FD-Score:-3.31|P-value:4.72E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein Gene:YFL063W(YFL063W_d)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Dubious open reading frame, based on available experimental and comparative sequence data Gene:YFR045W(YFR045W_p)|FD-Score:-3.16|P-value:8.01E-4||SGD DESC:Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white Gene:YGL176C(YGL176C_p)|FD-Score:-3.35|P-value:4.11E-4||SGD DESC:Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype Gene:YJL077W-B(YJL077W-B_p)|FD-Score:-5.13|P-value:1.48E-7||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YKL027W(YKL027W)|FD-Score:-3.38|P-value:3.68E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YLR422W(YLR422W_p)|FD-Score:3.21|P-value:6.75E-4||SGD DESC:Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein Gene:YML101C-A(YML101C-A_d)|FD-Score:3.23|P-value:6.14E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR141C(YMR141C_d)|FD-Score:-3.76|P-value:8.53E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR279C(YMR279C)|FD-Score:-3.18|P-value:7.47E-4||SGD DESC:Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication Gene:YNL295W(YNL295W_p)|FD-Score:3.84|P-value:6.13E-5||SGD DESC:Putative protein of unknown function Gene:YNL324W(YNL324W_d)|FD-Score:4.85|P-value:6.06E-7||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR042W(YNR042W_d)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2 Gene:YOR300W(YOR300W_d)|FD-Score:4.3|P-value:8.42E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 Gene:YPL041C(YPL041C_p)|FD-Score:-3.2|P-value:6.79E-4||SGD DESC:Protein of unknown function involved in maintenance of proper telomere length Gene:YPR159C-A(YPR159C-A_p)|FD-Score:3.5|P-value:2.36E-4||SGD DESC:Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL172W5.121.49E-70.32NUP49FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
YOR236W4.865.87E-70.32DFR1Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
YLR033W4.817.65E-70.32RSC58Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YNR016C4.493.64E-60.22ACC1Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
YML127W4.261.02E-50.21RSC9Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YOL038W4.062.51E-50.05PRE6Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
YOL135C4.003.14E-50.21MED7Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YHR062C3.797.40E-50.11RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YPL169C3.691.13E-40.07MEX67Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
YGR119C3.621.46E-40.10NUP57FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)
YNL306W3.522.17E-40.00MRPS18Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
YBR167C3.522.19E-40.16POP7Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YOL144W3.363.95E-40.04NOP8Nucleolar protein required for 60S ribosomal subunit biogenesis
YPL128C3.324.55E-40.01TBF1Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation
YMR290W-A_d3.304.77E-40.07YMR290W-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR285W5.141.39E-7RDL1Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress
YNL324W_d4.856.06E-7YNL324W_dDubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL027C_p4.788.59E-7YDL027C_pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene
YIL113W4.425.01E-6SDP1Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
YOR300W_d4.308.42E-6YOR300W_dDubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
YBR207W4.261.01E-5FTH1Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
YCL058C4.241.11E-5FYV5Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis
YML081C-A3.904.84E-5ATP18Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YNL295W_p3.846.13E-5YNL295W_pPutative protein of unknown function
YDL034W_d3.846.19E-5YDL034W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene
YJR094C3.797.64E-5IME1Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YMR088C3.691.14E-4VBA1Permease of basic amino acids in the vacuolar membrane
YBR205W3.691.14E-4KTR3Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
YFL063W_d3.671.23E-4YFL063W_dDubious open reading frame, based on available experimental and comparative sequence data
YCL076W_d3.651.31E-4YCL076W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

GO enrichment analysis for SGTC_2107
No biological processes are significantly enriched (FDR < 0.1).

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1575.85E-34SGTC_21405586273 200.0 μMChembridge (Fragment library)8544210.23913RSC complex & mRNA processing
0.1541.59E-32SGTC_21866124449 200.0 μMChembridge (Fragment library)38341820.078125RSC complex & mRNA processing
0.1482.00E-30SGTC_1652st011932 78.0 μMTimTec (Natural product derivative library)15510760.163934RSC complex & mRNA processing
0.1411.92E-27SGTC_8650488-0499 301.0 μMChemDiv (Drug-like library)96346510.0701754
0.1397.17E-27SGTC_21095483026 200.0 μMChembridge (Fragment library)7593350.12RSC complex & mRNA processing
0.1249.26E-22SGTC_643k048-0106 28.4 μMChemDiv (Drug-like library)67639200.147541RSC & ERG11
0.1241.74E-21SGTC_22297354935 190.0 μMChembridge (Fragment library)3181120.0892857RSC complex & mRNA processing
0.1201.84E-20SGTC_13742889-5571 141.0 μMChemDiv (Drug-like library)28532810.272727RSC complex & mRNA processing
0.1141.35E-18SGTC_21215257820 149.6 μMChembridge (Fragment library)7912560.1
0.1071.91E-16SGTC_7093807-1509 243.0 μMChemDiv (Drug-like library)18866770.0454545RSC complex & mRNA processing
0.1072.20E-16SGTC_249wiskostatin 11.2 μMICCB bioactive library27755100.105263
0.1025.17E-15SGTC_8710574-0004 149.0 μMChemDiv (Drug-like library)95511730.166667
0.1018.84E-15SGTC_6731082-0474 110.0 μMChemDiv (Drug-like library)30980460.181818RSC complex & mRNA processing
0.1001.67E-14SGTC_2534helenine 20.1 μMMicrosource (Natural product library)727240.0615385RSC complex & mRNA processing
0.0952.57E-13SGTC_2693st077581 40.7 μMTimTec (Natural product derivative library)252387610.164706

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_12011889-337245.9 μM0.3725495392199ChemDiv (Drug-like library)282.337023.49113Golgi
SGTC_3050909351349.47 μM0.36206925236664Chembridge (Drug-like library)352.898763.86913
SGTC_1935st07453241.6 μM0.3617022829742TimTec (Natural product derivative library)272.295843.55724
SGTC_3058909386149.47 μM0.34426217217477Chembridge (Drug-like library)373.876464.25504
SGTC_1300136-0219337.66 μM0.340426234244ChemDiv (Drug-like library)296.148643.77812
SGTC_3028908777849.47 μM0.33898317217395Chembridge (Drug-like library)373.876464.04304
SGTC_2826799254119.48 μM0.3333332985066Chembridge (Drug-like library)297.6845063.52514
SGTC_2981901395238.96 μM0.3207552996344Chembridge (Drug-like library)348.234324.39112
SGTC_23479049783174.81 μM0.326467988Chembridge (Fragment library)267.754521.95413
SGTC_2988907364071.43 μM0.329102229Chembridge (Drug-like library)283.364843.91512